Results 101 to 110 of about 466,841 (162)

The p53-Associated Regulation of ATF4 mRNA Expression Involves p21 and p130 in a Stress-Dependent Manner. [PDF]

Cells
Dalina A, Shilyaeva M, Kovaleva I, Chumakov P.   +3 more
europepmc   +1 more source

Special Issue "p53-Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell". [PDF]

Int J Mol Sci
Rangno D, Bozko P.
europepmc   +1 more source

NF-Y LOSS REACTIVATES p53 AND TRIGGERS p53-DEPENDENT APOPTOSIS IN HPV-POSITIVE HUMAN CERVICAL CARCINOMA CELLS

, 2014
The two early HPV genes, E6 and E7, play an essential role in cellular transformation and abnormal proliferation. The oncoprotein E6 suppresses the activation of p53-dependent pathways through proteasomal degradation of p53 and inhibition of its ...
IMBRIANO, Carol, BENATTI, Paolo, Mantovani, Roberto   +2 more
core  

Determinants of C₁₆-Ceramide Binding to p53. [PDF]

Biomolecules
Childress MS, Jeffries KA, Krupenko SA, Krupenko NI.   +3 more
europepmc   +1 more source

Study on the Transcription Regulation of Breast Cancer Amplified Sequence 2 (BCAS2) by p53 Tumor Suppressor

, 2010
新穎分子BCAS2已被發現在乳癌細胞株MCF7及MDA-MB-231，以及一些乳癌患者之臨床組織切片中，發現有基因放大或過度表現的的現象，並可能與乳癌細胞的侵襲性和遠端轉移有關。在本實驗室的研究中，發現默化BCAS2會導致MCF7細胞發生細胞凋亡，且細胞聚落形成能力降低。並發現BCAS2可以和抑癌蛋白p53結合，阻礙p53對下游目標基因如p21的轉錄活化，因此是一個p53的負向調控分子。53為細胞中最重要的抑癌分子之一，約有百分之五十以上的癌症被發現含有突變的p53 ...
林奕瑄, Lin, Yi-Hsuan
core  

p53 in Canine Mammary Tumors: From Molecular Pathogenesis to Biomarker Applications and Comparative Oncology. [PDF]

Vet Sci
Wang Z, Qin Y, Zeng Y, Liao S, Tao X, Liu X.   +5 more
europepmc   +1 more source

Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition. [PDF]

PLoS Genet
Khan C, Rusan NM, Baker NE.
europepmc   +1 more source

Mutant p53^R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation. [PDF]

Mol Oncol
Lim MC, Guo AK, Itahana Y, Kannan S, Goh V, Ong M, Tay TYW, Ye W, Krishnan SR, Nishiyama J, Verma CS, Itahana K.   +11 more
europepmc   +1 more source

JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines. [PDF]

Cell Death Discov
Saproo S, Papadaki S, Fernandez-Martinez J, Sultana P, Kanellis DC, Bartek J, Lindström MS.   +6 more
europepmc   +1 more source

Mechanisms Underlying Negative p53 Immunocytochemistry in Oral Cytology: <i>TP53</i> mRNA Expression and Sampling Limitations. [PDF]

Diagnostics (Basel)
Miyakawa T, Maruyama S, Yamazaki M, Abé T, Ono S, Tomihara K, Tanuma JI.   +6 more
europepmc   +1 more source