Results 71 to 80 of about 466,841 (162)

The Acetyltransferase p300/CBP-Associated Factor Is a p53 Target Gene in Breast Tumor Cells

Neoplasia: An International Journal for Oncology Research, 2004
p300/CBP-associated factor (PCAF) is a coactivator of the tumor suppressor, p53. PCAF participates in p53's transactivation of target genes through acetylation of both bound p53 and histones within p53 target promoters.
George S. Watts, Marc M. Oshiro, Damian J. Junk, Ryan J. Wozniak, Summer J. Watterson, Frederick E. Domann, Bernard W. Futscher   +6 more
doaj   +1 more source

Presença da proteína p53 em carcinomas epidermóides de cabeça e pescoço: correlação histopatológica e implicação prognóstica em 31 casos [PDF]

, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências MédicasIntrodução: A mutação do gene p53 é a alteração genética mais freqüentemente detectada em tumores de cabeça ...
Stoeberl, Luís Carlos
core  

Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.

PLoS Genetics, 2015
The downstream functions of the DNA binding tumor suppressor p53 vary depending on the cellular context, and persistent p53 activation has recently been implicated in tumor suppression and senescence.
Kristina Kirschner, Shamith A Samarajiwa, Jonathan M Cairns, Suraj Menon, Pedro A Pérez-Mancera, Kosuke Tomimatsu, Camino Bermejo-Rodriguez, Yoko Ito, Tamir Chandra, Masako Narita, Scott K Lyons, Andy G Lynch, Hiroshi Kimura, Tetsuya Ohbayashi, Simon Tavaré, Masashi Narita   +15 more
doaj   +1 more source

p32 is a negative regulator of p53 tetramerization and transactivation

Molecular Oncology, 2019
p53 is a sequence‐specific transcription factor, and proper regulation of p53 transcriptional activity is critical for orchestrating different tumor‐suppressive mechanisms.
Nikhil Baban Ghate, Jinman Kim, Yonghwan Shin, Alan Situ, Tobias S. Ulmer, Woojin An   +5 more
doaj   +1 more source

The mutational status of p53 can influence its recognition by human T-cells

OncoImmunology, 2017
p53 was reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in its inactivation and often accumulation in tumor cells.
Katerina Shamalov, Shlomo N. Levy, Miryam Horovitz-Fried, Cyrille J. Cohen   +3 more
doaj   +1 more source

Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways [PDF]

, 2013
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known ...
Ashcroft, M, Carroll, VA, Selvarajah, J, Moumen, A, Nathawat, K   +4 more
core   +2 more sources

Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a p53-transduced dendritic cell vaccine

npj Vaccines
Dendritic cells (DCs) transduced with replication-deficient, wild-type human p53-expressing adenovirus Ad-p53 (Ad-p53 DCs) induce p53-targeting cytotoxic T lymphocytes (CTLs).
Motohiko Yamada, Hiroshi Tazawa, Kanto Suemori, Naohiro Okada, Yoshinori Kajiwara, Ryohei Shoji, Yasuo Nagai, Hiroaki Inoue, Naoyuki Hashimoto, Nobuhiko Kanaya, Satoru Kikuchi, Shinji Kuroda, Hiroyuki Michiue, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara   +15 more
doaj   +1 more source

Unraveling the Role of TP53 in Colorectal Cancer Therapy: From Wild-Type Regulation to Mutant

Frontiers in Bioscience-Landmark
The p53, a pivotal tumor suppressor, regulates various cellular responses, including DNA repair and apoptosis. Normally, p53 levels are low due to murine double minute clone 2 (MDM2) mediated polyubiquitination.
Wenshu Li, Longyuan Li, Huan Yang, Chenxi Shi, Zhe Lei, Lingchuan Guo, Yuhong Wang   +6 more
doaj   +1 more source

Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53

Journal of Ovarian Research, 2019
Background While tumor suppressor p53 functions primarily as a transcription factor in the nucleus, cellular stress can cause p53 to translocate to the mitochondria and directly trigger a rapid apoptotic response. We have previously shown that fusing p53
Phong Lu, Erica R. Vander Mause, Katherine E. Redd Bowman, Sarah M. Brown, Lisa Ahne, Carol S. Lim   +5 more
doaj   +1 more source

MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis.

, 2004
Rescue of embryonic lethality in MDM4-/- mice through concomitant loss of p53 has revealed a functional partnership between the two proteins. Biochemical studies have suggested that MDM4 may act as a negative regulator of p53 levels and activity.
FARSETTI A, PONTECORVI A, Farsetti, Antonella, GENTILETTI F, MANCINI F, D'ANGELO M, MORETTI F., NANNI S, Moretti, Fabiola, CITRO G, Nanni, Simona, D'ANGELO C, SACCHI A, Pontecorvi, Alfredo, GIGLIO, SIMONA   +14 more
core   +1 more source