Results 61 to 70 of about 466,841 (162)

K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias [PDF]

, 2001
Background: The adenoma-carcinoma sequence has its molecular basis in several gene mutations of which K-ras and p53 are of paramount importance. The aims of this study were to evaluate whether these genetic alterations can be detected in colonic lavage ...
Folwaczny, Christian, Heinzlmann, M., Neynaber, S., Heldwein, W.   +3 more
core   +2 more sources

NAMPT Inhibitor and P73 Activator Represses P53 R175H Mutated HNSCC Cell Proliferation in a Synergistic Manner

Biomolecules, 2022
The p53 family has the following three members: p53, p63 and p73. p53 is a tumor suppressor gene that frequently exhibits mutation in head and neck cancer.
Bi-He Cai, Zhi-Yu Bai, Ching-Feng Lien, Si-Jie Yu, Rui-Yu Lu, Ming-Han Wu, Wei-Chen Wu, Chia-Chi Chen, Yi-Chiang Hsu   +8 more
doaj   +1 more source

Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas.

PLoS ONE, 2012
p53 is a tumor suppressor gene mutated in >50% of human cancers, while p53 deficiency in mice results in cancers and accelerated mortality. Thymic T cell lymphoma is the most common malignancy in p53-deficient mice, making it difficult to study the role ...
Y Jeffrey Chiang, Michael J Difilippantonio, Lino Tessarollo, Herbert C Morse, Richard J Hodes   +4 more
doaj   +1 more source

Prognostic value of immunohistochemically detected p53 in adjuvant chemotherapy-treated triple negative breast cancer

Kaohsiung Journal of Medical Sciences, 2018
Mutations of the p53 gene are the most common genomic alterations associated with triple-negative breast cancer (TNBC) and are reported in 60–88% cases. Despite the high incidence of such mutations, there is no consensus about the clinical application of
Soo Youn Bae, Seung Pil Jung, Se Kyung Lee, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam   +6 more
doaj   +1 more source

Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level. [PDF]

PLoS ONE, 2017
The repressive role of p53 on the human mitotic centromere-associated kinesin (MCAK) core promoter from ‒266 to +54, relative to the transcription start site, has been determined.
Do Youn Jun, Ji Young Lee, Hae Sun Park, Yun Han Lee, Young Ho Kim   +4 more
doaj   +1 more source

MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis

Advanced Science, 2023
Inactivation of the p53 pathway is linked to a variety of human cancers. As a critical component of the p53 pathway, ubiquitin‐specific protease 7 (USP7) acts as a deubiquitinase for both p53 and its ubiquitin E3 ligase mouse double minute 2 homolog ...
Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei   +10 more
doaj   +1 more source

The effects of two combined methods of P53 expression and preoperative serum CEA detection on the prognosis of colorectal cancer

Frontiers in Oncology
AimTo explore the effects of two combined methods—P53 expression and preoperative serum carcinoembryonic antigen (S-CEA) detection—on the prognosis of colorectal cancer (CRC).MethodsTwo classified combinations of tissue P53 and S-CEA were utilized ...
Guojun Tong, Guojun Tong, Yanyan Wang, Hai Qian, Zhenhua Tan, Yan Shen, Hui Li   +6 more
doaj   +1 more source

The antagonism between MCT-1 and p53 affects the tumorigenic outcomes

Molecular Cancer, 2010
Background MCT-1 oncoprotein accelerates p53 protein degradation via a proteosome pathway. Synergistic promotion of the xenograft tumorigenicity has been demonstrated in circumstance of p53 loss alongside MCT-1 overexpression.
Lin Tai-Du, Choy ChikOn, Wu Meng-Hsun, Shih Hung-Ju, Kasiappan Ravi, Chen Linyi, Hsu Hsin-Ling   +6 more
doaj   +1 more source

Gene expression profiles resulting from stable loss of p53 mirrors its role in tissue differentiation. [PDF]

PLoS ONE, 2013
The tumor suppressor gene p53 is involved in a variety of cellular activities such as cellular stress responses, cell cycle regulation and differentiation.
Oliver Couture, Eric Lombardi, Kendra Davis, Emily Hays, Nalini Chandar   +4 more
doaj   +1 more source

Modest effect of p53, EGFR and HER-2/neu on prognosis in epithelial ovarian cancer: a meta-analysis [PDF]

, 2009
Background: P53, egfr and her-2/neu are the most frequently studied molecular biological parameters in epithelial ovarian cancer, but their prognostic impact is still unequivocal.
de Jong, S., de Vries, E.G.E., de Bock, G.H.; id_orcid, Boezen, M., Post, W.J., van der Zee, A.G.J., de Vries, E.G.E.; id_orcid, Crijns, A.P.G., de Jong, S.; id_orcid, de Graeff, P., de Bock, G.H.   +10 more
core   +2 more sources