Results 51 to 60 of about 466,841 (162)
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53 [PDF]
, 2010 Background: The availability of various "omics" datasets creates a prospect of performing the study of genome-wide genetic regulatory networks. However, one of the major challenges of using mathematical models to infer genetic regulation from microarray ...
Junbai Wang +7 more
core +1 more source
Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination. [PDF]
PLoS ONE, 2011 The tumor suppressor p53 controls multiple cellular functions including DNA repair, cell cycle arrest and apoptosis. MDM2-mediated p53 ubiquitination affects both degradation and cytoplasmic localization of p53.
Ke-Sheng Wang +8 more
doaj +1 more source
Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms. [PDF]
, 2008 PPP1R13L was initially identified as a protein that binds to the NF-[kappa]B subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action.
Magdalena J. Laska +7 more
core
The human adenovirus 5 L4 promoter is activated by cellular stress response protein p53 [PDF]
, 2013 During adenovirus infection, the emphasis of gene expression switches from early genes to late genes in a highly regulated manner. Two gene products, L4-22K and L4-33K, contribute to this switch by activating the Major Late Transcription Unit (MLTU) and ...
Leppard, Keith, Wright, Jordan
core +1 more source
Nature Communications, 2023 The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a mouse model of
Jonuelle Acosta +18 more
doaj +1 more source
p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis [PDF]
, 2013 The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated.
Graf, M +47 more
core +1 more source
Bioluminescence Detection of Cells Having Stabilized p53 in Response to a Genotoxic Event
Molecular Imaging, 2004 Inactivation of p53 is one of the most frequent molecular events in neoplastic transformation. Approximately 60% of all human tumors have mutations in both p53 alleles.
Alnawaz Rehemtulla +2 more
doaj +1 more source
Conservative Treatment of HAV-Associated Acalculous Acute Cholecystitis in an Adult: A Case Report
Case Reports in MedicineHepatitis A virus (HAV) is a viral infection that can present with a wide range of clinical manifestations, including rare complications such as acute acalculous cholecystitis (AAC). We present the case of a 31-year-old woman who arrived at the emergency
Sebastian A. Medina-Ramirez +3 more
doaj +1 more source
Tumor Biology, 2017 As a transcription factor, p53 must accumulate in the nucleus to be effective. Signals related to nuclear localization are distributed mainly in the C-terminal of p53.
Weiying Li +4 more
doaj +1 more source
Cell Reports, 2017 Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression.
Xiao Ling Li +28 more
doaj +1 more source