A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. [PDF]
, 2011 BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks
Valentine, Jane M. +11 more
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Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Cell Reports, 2018 Summary: The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available.
Le-Ann Hwang +10 more
doaj +1 more source
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. [PDF]
PLoS ONE, 2010 A hallmark of p53 function is to regulate a transcriptional program in response to extracellular and intracellular stress that directs cell cycle arrest, apoptosis, and cellular senescence.
SiDe Li +5 more
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Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3 [PDF]
, 2007 Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis.
Underwood, Timothy J. +7 more
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Marine Drugs, 2018 Benderamide A (1), a (S)-2,2-dimethyl-3-hydroxy-7-octynoic acid (S-Dhoya)-containing cyclic depsipeptide that belongs to the kulolide superfamily, was isolated from a Singapore collection of cf. Lyngbya sp.
Chi Ying Gary Ding +4 more
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p53 Expression in Colorectal Carcinoma in Relation to Histopathological Features in Ugandan Patients. [PDF]
, 2008 It has been shown that colorectal carcinoma is increasing in incidence in African countries. This could be due to change in life style. Molecular pathogenesis of colorectal cancer commonly involves mutation in p53 gene which leads to expression of p53 ...
Rambau, PF +6 more
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P53 mutations in human adrenocortical neoplasms [PDF]
, 1994 The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer.
Travis, W. +6 more
core +1 more source
Frontiers in Immunology, 2018 Many therapeutic antibodies are humanized from animal sources. In the humanization process, complementarity determining region grafting is tedious and highly prone to failure.
Wei-Li Ling +6 more
doaj +1 more source
A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53. [PDF]
PLoS ONE, 2016 p53 function is frequently inhibited in cancer either through mutations or by increased degradation via MDM2 and/or E6AP E3-ubiquitin ligases. Most agents that restore p53 expression act by binding MDM2 or E6AP to prevent p53 degradation.
John Bechill +4 more
doaj +1 more source
Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription [PDF]
, 2003 The transcription factor p53 lies at the center of a protein network that controls cell cycle progression and commitment to apoptosis. p53 is inactive in proliferating cells, largely because of negative regulation by the Hdm2/Mdm2 oncoprotein, with which
Darley, Matthew +11 more
core +1 more source