Results 31 to 40 of about 342,417 (266)
BMC Biology, 2017 Background Protein–protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop inhibitors of biological processes such as host-pathogen interactions and cancer cell proliferation.
Jin Huei Wong +6 more
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Identification of Small Molecules that Modulate Mutant p53 Condensation
iScience, 2020 Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions ...
Clara Lemos +21 more
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Genome Biology, 2013 A new study identifies the long noncoding RNA Pintas a regulator of cellular proliferation and a target of the p53 pathway.
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The Journal of Pathology, 1999 Abnormalities of the p53 tumour suppressor gene are among the most frequent molecular events in human and animal neoplasia. Moreover, p53 is one of the most studied proteins in the whole of contemporary biology, with more than 12,500 papers so far written!
C, Prives, P A, Hall
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Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Cell Reports, 2018 Summary: The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available.
Le-Ann Hwang +10 more
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p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. [PDF]
PLoS ONE, 2010 A hallmark of p53 function is to regulate a transcriptional program in response to extracellular and intracellular stress that directs cell cycle arrest, apoptosis, and cellular senescence.
SiDe Li +5 more
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p53 β-hydroxybutyrylation attenuates p53 activity [PDF]
Cell Death & Disease, 2019 Abstractp53 is an essential tumor suppressor, whose activity is finely tuned by the posttranslational modifications. Previous research has reported that β-hydroxybutyrate (BHB) induces β-hydroxybutyrylation (Kbhb), which is a novel histone posttranslational modification.
Kun Liu +13 more
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USP11 regulates p53 stability by deubiquitinating p53 [PDF]
Journal of Zhejiang University SCIENCE B, 2014 The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor suppressor function, which is tightly controlled by ubiquitin-dependent degradation primarily through its negative regulator murine double ...
Jia-ying, Ke +7 more
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Marine Drugs, 2018 Benderamide A (1), a (S)-2,2-dimethyl-3-hydroxy-7-octynoic acid (S-Dhoya)-containing cyclic depsipeptide that belongs to the kulolide superfamily, was isolated from a Singapore collection of cf. Lyngbya sp.
Chi Ying Gary Ding +4 more
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Circulation Research, 2001 Subendothelial macrophages are a major cellular component of atherosclerotic lesions. In response to subendothelial retention of modified lipoproteins,1 2 blood-borne monocytes enter the subendothelial space, differentiate into macrophages, and accumulate large amounts of lipoprotein-derived cholesterol (foam cells).3 4 Specific consequences of ...
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