Results 31 to 40 of about 430,765 (317)
Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Cell Reports, 2018 Summary: The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available.
Le-Ann Hwang +10 more
doaj +1 more source
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. [PDF]
PLoS ONE, 2010 A hallmark of p53 function is to regulate a transcriptional program in response to extracellular and intracellular stress that directs cell cycle arrest, apoptosis, and cellular senescence.
SiDe Li +5 more
doaj +1 more source
p53 β-hydroxybutyrylation attenuates p53 activity [PDF]
Cell Death & Disease, 2019 Abstractp53 is an essential tumor suppressor, whose activity is finely tuned by the posttranslational modifications. Previous research has reported that β-hydroxybutyrate (BHB) induces β-hydroxybutyrylation (Kbhb), which is a novel histone posttranslational modification.
Kun Liu +13 more
openaire +2 more sources
Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3 [PDF]
, 2007 Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis.
Underwood, Timothy J. +7 more
core +1 more source
USP11 regulates p53 stability by deubiquitinating p53 [PDF]
Journal of Zhejiang University SCIENCE B, 2014 The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor suppressor function, which is tightly controlled by ubiquitin-dependent degradation primarily through its negative regulator murine double ...
Jia-ying, Ke +7 more
openaire +2 more sources
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane [PDF]
, 2002 p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 ...
Bourdon, J.-C.; id_orcid +9 more
core +1 more source
Marine Drugs, 2018 Benderamide A (1), a (S)-2,2-dimethyl-3-hydroxy-7-octynoic acid (S-Dhoya)-containing cyclic depsipeptide that belongs to the kulolide superfamily, was isolated from a Singapore collection of cf. Lyngbya sp.
Chi Ying Gary Ding +4 more
doaj +1 more source
Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription [PDF]
, 2003 The transcription factor p53 lies at the center of a protein network that controls cell cycle progression and commitment to apoptosis. p53 is inactive in proliferating cells, largely because of negative regulation by the Hdm2/Mdm2 oncoprotein, with which
Darley, Matthew +11 more
core +1 more source
Frontiers in Immunology, 2018 Many therapeutic antibodies are humanized from animal sources. In the humanization process, complementarity determining region grafting is tedious and highly prone to failure.
Wei-Li Ling +6 more
doaj +1 more source
A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53. [PDF]
PLoS ONE, 2016 p53 function is frequently inhibited in cancer either through mutations or by increased degradation via MDM2 and/or E6AP E3-ubiquitin ligases. Most agents that restore p53 expression act by binding MDM2 or E6AP to prevent p53 degradation.
John Bechill +4 more
doaj +1 more source