Results 11 to 20 of about 342,417 (266)
Living with p53, Dying of p53 [PDF]
Cell, 2007 The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate the life and death decisions of p53.
Aylon, Yael, Oren, Moshe
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Functional display of bioactive peptides on the vGFP scaffold
Scientific Reports, 2021 Grafting bioactive peptides into recipient protein scaffolds can often increase their activities by conferring enhanced stability and cellular longevity. Here, we describe use of vGFP as a novel scaffold to display peptides. vGFP comprises GFP fused to a
Sharon Min Qi Chee +6 more
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F1000Research, 2022 Background: The measures taken to contain the COVID-19 pandemic, led to significant changes in university education, resulting in the new normal standard of virtual teaching in many undergraduate medical schools worldwide.
Fiorella Hernandez +4 more
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p53-Induced DNA Bending: The Interplay between p53−DNA and p53−p53 Interactions [PDF]
The Journal of Physical Chemistry B, 2008 Specific p53 binding-induced DNA bending and its underlying responsible forces are crucial for the understanding of selective transcription activation. Diverse p53-response elements exist in the genome; however, it is not known what determines the DNA bending and to what extent.
Yongping, Pan, Ruth, Nussinov
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Journal of Nutrition and Metabolism, 2021 Background. Peru has one of the highest infection and death rates in the world for the COVID-19 pandemic. The government implemented house confinement measures with probable consequences on lifestyle, particularly affecting eating habits, physical ...
Salomón Huancahuire-Vega +7 more
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Nature Communications, 2022 Approaches have been devised to increase the discovery rate of intrabodies but often these yield results that aren’t functional in cells. Here the authors engineer and optimise an autonomous and disulphide-free human VH domain for intracellular ...
Yuri Frosi +18 more
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Atención Primaria, 2022 Resumen: Objetivo: Elaborar una escala válida y fiable para medir el rol del profesional de enfermería en la comunidad (REFCO). Diseño: Estudio observacional con diseño transversal de tipo instrumental.
Evelyn M. Mamani-Vilca +5 more
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Journal of Cell Science, 2010 Since its discovery in 1979, the role of the p53 protein in cancer has been studied intensively ([Levine and Oren, 2009][1]). p53 is a crucial tumor suppressor, long-recognized to suppress cancer through the induction of cell-cycle-arrest or apoptosis programs in response to a plethora of ...
Colleen A, Brady, Laura D, Attardi
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Cold Spring Harbor Perspectives in Medicine, 2015 Our understanding of medulloblastoma biology has increased dramatically over the past decade, in part a result of the recognition that there exists tremendous intertumoral heterogeneity not apparent by morphology alone. A particular area that significantly changed our approach to medulloblastoma has been an increased understanding of the role of p53. A
Vijay, Ramaswamy +2 more
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Frontiers in Oncology, 2021 BackgroundWe conducted an analysis of previous adenoviral p53 (Ad-p53) treatment data in recurrent head and neck squamous cell carcinoma (HNSCC) patients to identify optimal Ad-p53 treatment methods for future clinical trials.MethodsThe analysis involved
Robert E. Sobol +6 more
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