Results 11 to 20 of about 466,841 (162)

Functional display of bioactive peptides on the vGFP scaffold

Scientific Reports, 2021
Grafting bioactive peptides into recipient protein scaffolds can often increase their activities by conferring enhanced stability and cellular longevity. Here, we describe use of vGFP as a novel scaffold to display peptides. vGFP comprises GFP fused to a
Sharon Min Qi Chee, Jantana Wongsantichon, Lau Sze Yi, Barindra Sana, Yuri Frosi, Robert C. Robinson, Farid J. Ghadessy   +6 more
doaj   +1 more source

Online academic satisfaction during the COVID-19 pandemic in medical students: role of sleep, psychological issues, college adjustment, and digital skills [version 3; peer review: 2 approved]

F1000Research, 2022
Background: The measures taken to contain the COVID-19 pandemic, led to significant changes in university education, resulting in the new normal standard of virtual teaching in many undergraduate medical schools worldwide.
Fiorella Hernandez, Josue F. Canaza, Salomón Huancahuire-Vega, Ricardo Rojas-Humpire, Sebastian A. Medina-Ramirez   +4 more
doaj   +1 more source

Changes in Eating Habits and Lifestyles in a Peruvian Population during Social Isolation for the COVID-19 Pandemic

Journal of Nutrition and Metabolism, 2021
Background. Peru has one of the highest infection and death rates in the world for the COVID-19 pandemic. The government implemented house confinement measures with probable consequences on lifestyle, particularly affecting eating habits, physical ...
Salomón Huancahuire-Vega, Edda E. Newball-Noriega, Ricardo Rojas-Humpire, Jacksaint Saintila, Mery Rodriguez-Vásquez, Percy. G. Ruiz-Mamani, Wilter C. Morales-García, Michael White   +7 more
doaj   +1 more source

Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

Nature Communications, 2022
Approaches have been devised to increase the discovery rate of intrabodies but often these yield results that aren’t functional in cells. Here the authors engineer and optimise an autonomous and disulphide-free human VH domain for intracellular ...
Yuri Frosi, Yen-Chu Lin, Jiang Shimin, Siti Radhiah Ramlan, Kelly Hew, Alf Henrik Engman, Anil Pillai, Kit Yeung, Yue Xiang Cheng, Tobias Cornvik, Par Nordlund, Megan Goh, Dilraj Lama, Zachary P. Gates, Chandra S. Verma, Dawn Thean, David P. Lane, Ignacio Asial, Christopher J. Brown   +18 more
doaj   +1 more source

Validación de un cuestionario que mide las percepciones del rol del profesional de enfermería comunitaria en Perú

Atención Primaria, 2022
Resumen: Objetivo: Elaborar una escala válida y fiable para medir el rol del profesional de enfermería en la comunidad (REFCO). Diseño: Estudio observacional con diseño transversal de tipo instrumental.
Evelyn M. Mamani-Vilca, Isabel P. Pelayo-Luis, Anali Terrones Guevara, Janett V. Chávez Sosa, Renzo Felipe Carranza-Esteban, Salomón Huancahuire-Vega   +5 more
doaj   +1 more source

Analysis of Adenoviral p53 Gene Therapy Clinical Trials in Recurrent Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundWe conducted an analysis of previous adenoviral p53 (Ad-p53) treatment data in recurrent head and neck squamous cell carcinoma (HNSCC) patients to identify optimal Ad-p53 treatment methods for future clinical trials.MethodsThe analysis involved
Robert E. Sobol, Kerstin B. Menander, Sunil Chada, Dora Wiederhold, Beatha Sellman, Max Talbott, John J. Nemunaitis   +6 more
doaj   +1 more source

Characterisation of the p53-Mediated Cellular Responses Evoked in Primary Mouse Cells Following Exposure to Ultraviolet Radiation [PDF]

, 2013
Exposure to ultraviolet (UV) light can cause significant damage to mammalian cells and, although the spectrum of damage produced varies with the wavelength of UV, all parts of the UV spectrum are recognised as being detrimental to human health ...
McFeat, Gillian, McMillan, Trevor, Allinson, Sarah   +2 more
core   +5 more sources

Role of p53 serine 46 in p53 target gene regulation [PDF]

, 2011
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of different response pathways. The molecular mechanisms that discriminate between the distinct p53-responses have remained largely elusive.
Bianca Gilbert, Simon J. van Heeringen, Smeenk, L., Hendrik G Stunnenberg, Smeenk, Leonie, Eva Janssen-Megens, Lohrum, Marion, Koeppel, M., Heeringen, S.J. van, Hendrik G. Stunnenberg, Gilbert, Bianca, Lohrum, M., Stunnenberg, H.G., Stunnenberg, Hendrik G., Max Koeppel, Leonie Smeenk, Janssen-Megens, Eva, Heeringen, Simon J. van, Janssen-Megens, E.M., Marion Lohrum, Gilbert, B., Köppel, Max, Simon J van Heeringen   +22 more
core   +3 more sources

Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

Nanomaterials, 2020
Stapled peptides targeting the interaction between p53 and its negative regulators MDM2 and MDM4 have exhibited great potential as anti-cancer drugs, albeit with room for improvement in formulation and tumor specificity.
Sara Lundsten, Víctor Agmo Hernández, Lars Gedda, Tina Sarén, Christopher J. Brown, David P. Lane, Katarina Edwards, Marika Nestor   +7 more
doaj   +1 more source

Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly

BMC Biology, 2019
Background The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery.
Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane, Christopher J. Brown   +4 more
doaj   +1 more source