Results 11 to 20 of about 430,765 (317)
Role of p53 serine 46 in p53 target gene regulation [PDF]
, 2011 The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of different response pathways. The molecular mechanisms that discriminate between the distinct p53-responses have remained largely elusive.
Bianca Gilbert +22 more
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Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
Nanomaterials, 2020 Stapled peptides targeting the interaction between p53 and its negative regulators MDM2 and MDM4 have exhibited great potential as anti-cancer drugs, albeit with room for improvement in formulation and tumor specificity.
Sara Lundsten +7 more
doaj +1 more source
Annals of Oncology, 1999 Although hematologic malignancies and some solid tumors such as germ cell tumors and pediatric malignancies can be cured by cytotoxic treatment, the most prevalent solid tumors are relatively resistant to these interventions. Apoptosis is involved in the cell kill of anticancer drugs and p53 is believed to be of principal importance in this process ...
Ferreira, C.G., Tolis, C., Giaccone, G.
openaire +4 more sources
Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly
BMC Biology, 2019 Background The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery.
Yuri Frosi +4 more
doaj +1 more source
Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]
, 2000 This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia +6 more
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The SWIB/MDM2 motif of UBE4B activates the p53 pathway
Molecular Therapy: Nucleic Acids, 2023 The tumor suppressor p53 plays a critical role in cancer pathogenesis, and regulation of p53 expression is essential for maintaining normal cell growth. UBE4B is an E3/E4 ubiquitin ligase involved in a negative-feedback loop with p53.
H. Helena Wu +5 more
doaj +1 more source
p53 isoforms change p53 paradigm [PDF]
Molecular & Cellular Oncology, 2014 Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called p53 does not exist as a single protein, but is in fact a group of p53 protein isoforms whose expression can be manipulated to control the cellular response to treatment.
openaire +3 more sources
Scientific Reports, 2017 Linear peptides can mimic and disrupt protein-protein interactions involved in critical cell signaling pathways. Such peptides however are usually protease sensitive and unable to engage with intracellular targets due to lack of membrane permeability ...
D. Thean +8 more
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Microbial Cell Factories, 2019 Background Acrylic acid (AA) is a widely used commodity chemical derived from non-renewable fossil fuel sources. Alternative microbial-based production methodologies are being developed with the aim of providing “green” acrylic acid.
Sarada S. Raghavan +7 more
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Frontiers in Oncology, 2020 RationalcMet is abnormally regulated in gastrointestinal cancer, and is associated with increased invasiveness of the disease and poor overall survival.
Diana Spiegelberg +9 more
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