Results 21 to 30 of about 466,841 (162)

The SWIB/MDM2 motif of UBE4B activates the p53 pathway

Molecular Therapy: Nucleic Acids, 2023
The tumor suppressor p53 plays a critical role in cancer pathogenesis, and regulation of p53 expression is essential for maintaining normal cell growth. UBE4B is an E3/E4 ubiquitin ligase involved in a negative-feedback loop with p53.
H. Helena Wu, Sarah Leng, Yasser Abuetabh, Consolato Sergi, David D. Eisenstat, Roger Leng   +5 more
doaj   +1 more source

Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery

Scientific Reports, 2017
Linear peptides can mimic and disrupt protein-protein interactions involved in critical cell signaling pathways. Such peptides however are usually protease sensitive and unable to engage with intracellular targets due to lack of membrane permeability ...
D. Thean, J. S. Ebo, T. Luxton, Xue’Er Cheryl Lee, T. Y. Yuen, F. J. Ferrer, C. W. Johannes, D. P. Lane, C. J. Brown   +8 more
doaj   +1 more source

Development and application of a transcriptional sensor for detection of heterologous acrylic acid production in E. coli

Microbial Cell Factories, 2019
Background Acrylic acid (AA) is a widely used commodity chemical derived from non-renewable fossil fuel sources. Alternative microbial-based production methodologies are being developed with the aim of providing “green” acrylic acid.
Sarada S. Raghavan, Sharon Chee, Juntao Li, Jeremie Poschmann, Niranjan Nagarajan, Siau Jia Wei, Chandra S. Verma, Farid J. Ghadessy   +7 more
doaj   +1 more source

The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

Frontiers in Oncology, 2020
RationalcMet is abnormally regulated in gastrointestinal cancer, and is associated with increased invasiveness of the disease and poor overall survival.
Diana Spiegelberg, Diana Spiegelberg, Anja Charlotte Lundgren Mortensen, Kartika Dyah Palupi, Patrick Micke, Julin Wong, Borivoj Vojtesek, David Philip Lane, David Philip Lane, Marika Nestor   +9 more
doaj   +1 more source

The Basally Expressed p53-Mediated Homeostatic Function

Frontiers in Cell and Developmental Biology, 2021
Apart from mutations in the p53 gene, p53 functions can be alternatively compromised by a decrease in nuclear p53 protein levels or activities. In accordance, enhanced p53 protein turnover due to elevated expression of the critical p53 E3 ligase MDM2 or ...
Isha Nagpal, Zhi-Min Yuan
doaj   +1 more source

Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]

, 2000
This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia, Lane, David P., T. Hay, Ronald, Hay, Ronald Thomas, Rodriguez, Manuel S, Desterro, Joana M P   +6 more
core   +1 more source

Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]

, 2012
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Daniel P. Teufel, Fiona M. Townsley (123705), Stefan M. V. Freund (123709), Stefan M V Freund, Teufel, Daniel P., Stefan M. V. Freund, Daniel P. Teufel (123707), Tobias Br, Tobias Brandt (123703), Townsley, Fiona M., Dmitry B Veprintsev, Veprintsev, Dmitry B., Fiona M. Townsley, Tobias Brandt, Dmitry B. Veprintsev (109095), Freund, Stefan M. V., Daniel P Teufel, Fiona M Townsley, Dmitry B. Veprintsev, Brandt, Tobias   +19 more
core   +2 more sources

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Caselmann, Wolfgang H., Gerbes, Alexander L.   +1 more
core   +1 more source

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

BMC Biology, 2017
Background Protein–protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop inhibitors of biological processes such as host-pathogen interactions and cancer cell proliferation.
Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S. Verma, David P. Lane, Prakash Arumugam   +6 more
doaj   +1 more source

Identification of Small Molecules that Modulate Mutant p53 Condensation

iScience, 2020
Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions ...
Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura Martina Luh, Thomas Markus Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann   +21 more
doaj   +1 more source