Results 21 to 30 of about 342,417 (266)
Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
Nanomaterials, 2020 Stapled peptides targeting the interaction between p53 and its negative regulators MDM2 and MDM4 have exhibited great potential as anti-cancer drugs, albeit with room for improvement in formulation and tumor specificity.
Sara Lundsten +7 more
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Annals of Oncology, 1999 Although hematologic malignancies and some solid tumors such as germ cell tumors and pediatric malignancies can be cured by cytotoxic treatment, the most prevalent solid tumors are relatively resistant to these interventions. Apoptosis is involved in the cell kill of anticancer drugs and p53 is believed to be of principal importance in this process ...
Ferreira, C.G., Tolis, C., Giaccone, G.
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Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly
BMC Biology, 2019 Background The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery.
Yuri Frosi +4 more
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The SWIB/MDM2 motif of UBE4B activates the p53 pathway
Molecular Therapy: Nucleic Acids, 2023 The tumor suppressor p53 plays a critical role in cancer pathogenesis, and regulation of p53 expression is essential for maintaining normal cell growth. UBE4B is an E3/E4 ubiquitin ligase involved in a negative-feedback loop with p53.
H. Helena Wu +5 more
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p53 isoforms change p53 paradigm [PDF]
Molecular & Cellular Oncology, 2014 Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called p53 does not exist as a single protein, but is in fact a group of p53 protein isoforms whose expression can be manipulated to control the cellular response to treatment.
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Scientific Reports, 2017 Linear peptides can mimic and disrupt protein-protein interactions involved in critical cell signaling pathways. Such peptides however are usually protease sensitive and unable to engage with intracellular targets due to lack of membrane permeability ...
D. Thean +8 more
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Microbial Cell Factories, 2019 Background Acrylic acid (AA) is a widely used commodity chemical derived from non-renewable fossil fuel sources. Alternative microbial-based production methodologies are being developed with the aim of providing “green” acrylic acid.
Sarada S. Raghavan +7 more
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Frontiers in Oncology, 2020 RationalcMet is abnormally regulated in gastrointestinal cancer, and is associated with increased invasiveness of the disease and poor overall survival.
Diana Spiegelberg +9 more
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The Basally Expressed p53-Mediated Homeostatic Function
Frontiers in Cell and Developmental Biology, 2021 Apart from mutations in the p53 gene, p53 functions can be alternatively compromised by a decrease in nuclear p53 protein levels or activities. In accordance, enhanced p53 protein turnover due to elevated expression of the critical p53 E3 ligase MDM2 or ...
Isha Nagpal, Zhi-Min Yuan
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Cold Spring Harbor Symposia on Quantitative Biology, 2016 This perspective will focus on the physiological impact of wild-type and mutant p53 activities. In particular, the tissue-specific nature of activation of p53 targets and their subsequent effects on cell behavior will be discussed. Because mutations in p53 are common in human cancers, the regulation and physiological consequences of mutant p53 proteins
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