Results 41 to 50 of about 466,841 (162)

Identification and Characterization of an eIF4e DNA Aptamer That Inhibits Proliferation With High Throughput Sequencing

Molecular Therapy: Nucleic Acids, 2014
Development of DNA aptamer screens that are both simple and informative can increase the success rate of DNA aptamer selection and induce greater adoption.
Wei Mei Guo, Kiat Whye Kong, Christopher John Brown, Soo Tng Quah, Hui Ling Yeo, Shawn Hoon, Yiqi Seow   +6 more
doaj   +1 more source

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane [PDF]

, 2002
p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 ...
Bourdon, J.-C.; id_orcid, K.N. Fernandes, P.L. Robertson, Robertson, P. L., J.-C. Bourdon, Fernandes, K. N., Lane, D. P., J. Renzing, Renzing, J., D.P. Lane   +9 more
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The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]

, 2014
p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
J Das, S Menendez, Menendez, S., Saville, M. K., S Dayal, Das, J., M K Saville, Dayal, S., A Sparks, Robertson, P., P Robertson, Sparks, A.   +11 more
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SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53 [PDF]

, 2010
Background The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-
Ahmed, Shafiq U., Milner, J, Jack Ford, Li, Han, Li, H, Ford, J, Serrano, M, Lynch, CJ, Milner, Jo, Ford Jack, Han Li, Blagosklonny, Mikhail V., Ahmed, Shafiq, Allison, SJ, Jo Milner, Simon J Allison, Simon J. Allison, Manuel Serrano, Warnock Lorna J., Warnock, LJ, Lorna J Warnock, Zahid H. Shah, Shafiq U Ahmed, Lorna J. Warnock, Serrano, Manuel, Shah, ZH, Lynch Cian J., Shah, Zahid H., Allison, Simon J., Shah Zahid H., Shafiq U. Ahmed, Serrano Manuel, Milner Jo, Cian J. Lynch, Lynch, Cian J., Li Han, Ahmed Shafiq U., Allison Simon J., Ford, Jack, Warnock, Lorna J., Cian J Lynch, Zahid H Shah   +41 more
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P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9

Neoplasia: An International Journal for Oncology Research, 2021
A long-term goal in the cancer-field has been to develop strategies for treating p53-mutated tumors. A novel small-molecule, PG3-Oc, restores p53 pathway-signaling in tumor cells with mutant-p53, independently of p53/p73. PG3-Oc partially upregulates the
Xiaobing Tian, Nagib Ahsan, Amriti Lulla, Avital Lev, Philip Abbosh, David T. Dicker, Shengliang Zhang, Wafik S. El-Deiry   +7 more
doaj   +1 more source

Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells [PDF]

, 2010
We have previously reported that deletion of the retinoblastoma gene Rb leads to rapid but transient p53 stabilisation. We investigated here the pathways involved.
Bellamy, Christopher, Harrison, David J, Treanor, Louise, Prost, Sandrine, Harrison, David J.   +4 more
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Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. [PDF]

, 2012
Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53 ...
Eckhard Wolf, Marlene Edlinger, Marlene Edlinger (133272), Eckhard Wolf (39870), Krzysztof Flisikowski (133283), Mayuko Kurome, Claudia Merkl (133270), Kurome, Mayuko, Claudia Merkl, Alexander Kind, Valeri Zakhartchenko, Flisikowski, Krzysztof, Simon Leuchs (133268), Nousin Rezaei, Anja Saalfrank, Valeri Zakhartchenko (133278), Marina Durkovic (133273), Marina Durkovic, Krzysztof Flisikowski, Flisikowska, Tatiana, Kessler, Barbara, Saalfrank, Anja, Merkl, Claudia, Schnieke, Angelika, Simon Leuchs, Kind, Alexander, Zakhartchenko, Valeri, Barbara Kessler (133280), Alexander Kind (133287), Edlinger, Marlene, Mayuko Kurome (133277), Wolf, Eckhard, Rezaei, Nousin, Nousin Rezaei (133275), Angelika Schnieke (133290), Tatiana Flisikowska, Angelika Schnieke, Anja Saalfrank (133269), Tatiana Flisikowska (133271), Barbara Kessler, Leuchs, Simon, Durkovic, Marina   +41 more
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Molecular Characterization of ‘p53 Family Network’ in Human Head and Neck Cancer and Anti-EGFR Therapy [PDF]

, 2008
Understanding of p53 family protein (p53, p63 and p73) networks in head and neck squamous cell carcinoma (HNSCC), can positively influence in cancer screening, diagnosis, treatment and prevention.
Sebastian, Sinto
core   +1 more source

MDM2 inhibitors-mediated disruption of mitochondrial metabolism: A novel therapeutic strategy for retinoblastoma

Frontiers in Oncology, 2022
MDM2 is the principal inhibitor of p53, and MDM2 inhibitors can disrupt the physical interaction between MDM2 and p53. The half-life of p53 is very short in normal cells and tissues, and an uncontrolled increase in p53 levels has potential harmful ...
Arianna Romani, Enrico Zauli, Giorgio Zauli, Saleh AlMesfer, Samar Al-Swailem, Rebecca Voltan   +5 more
doaj   +1 more source

A novel regulator of the p53-mediated mitochondrial apoptotic pathway [PDF]

, 2008
The p53 tumor suppressor protein induces apoptosis in response to genotoxic and environmental stress. Recent studies have revealed the existence of a transcription-independent mitochondrial p53 apoptosis pathway, however the mechanism regulating p53 ...
Bo Young Ahn, Sung-Woo Kim, Diane Trinh, Laura Zajchowski   +3 more
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