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Pattern of Lymph Node Metastasis and p53 Abnormal (p53abn) Expression in Preoperative Early-stage Endometrial Cancer: A 5-year Institutional Experience. [PDF]
Acta Med PhilippAng AAC +4 more
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Dynamic, anthracycline-induced chromatin alterations enable ALDH1 expression as a mechanism of inducible leukemia resistance development. [PDF]
Blood ResVlahopoulos SA.
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piR-61298 promotes colorectal cancer progression through destabilizing p53 by interacting with USP10. [PDF]
J Biomed ResXu S +7 more
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p53 Immunohistochemistry Expression in Epithelial Ovarian Tumors. [PDF]
CureusMadini S, Suresh TN, Kattepur AK.
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WWP2 ubiquitin ligase promotes colorectal cancer progression by targeting p53 for degradation: an experimental study. [PDF]
Ann Surg Treat ResLee SJ +12 more
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p53-Induced Apoptosis and Inhibitors of p53
Current Medicinal Chemistry, 2009Protein p53 is a key player in mitochondrial mediated apoptotic cell death and excess p53 activity has been implicated in many disease states such athrosclerosis, diabetes, osteoarthritis, Alzheimer's disease, Parkinson's disease, Huntington's disease, AIDS, P. falciparum and S. typhimurium infections.
Surendra Kumar, Nayak +2 more
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Fertility and Sterility, 2018
Tumor protein 53 (TP53) and its related family of p63 and p73 are tumor suppressor genes that regulate cellular activity to enhance longevity. p53 binds to specific response elements in DNA, modulating the transcription of genes that govern the major defenses against tumor growth.
Hey-Joo, Kang, Zev, Rosenwaks
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Tumor protein 53 (TP53) and its related family of p63 and p73 are tumor suppressor genes that regulate cellular activity to enhance longevity. p53 binds to specific response elements in DNA, modulating the transcription of genes that govern the major defenses against tumor growth.
Hey-Joo, Kang, Zev, Rosenwaks
openaire +2 more sources
Seminars in Cancer Biology, 1998
One of the several biological functions attributed to p53 is the ability to induce apoptotic cell suicide. It has become clear that this apoptotic activity of p53 is central to its role as a tumor suppressor. A summary of current knowledge concerning the mechanisms of p53-mediated apoptosis is presented.
T M, Gottlieb, M, Oren
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One of the several biological functions attributed to p53 is the ability to induce apoptotic cell suicide. It has become clear that this apoptotic activity of p53 is central to its role as a tumor suppressor. A summary of current knowledge concerning the mechanisms of p53-mediated apoptosis is presented.
T M, Gottlieb, M, Oren
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Nature Reviews Cancer, 2009
Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms.
Karen H, Vousden, Kevin M, Ryan
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Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms.
Karen H, Vousden, Kevin M, Ryan
openaire +2 more sources