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Computational protein chemistry of p53 and p53 peptides
Frontiers in Bioscience, 2004Computational protein chemistry has potential to contribute to the development of new therapeutic approaches in medicine in several different ways, including indirectly by increasing understanding of the disease-associated changes in protein structure that are mechanistically important, which can have diagnostic implications, as well as directly in ...
Paul W, Brandt-Rauf +3 more
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The p53 network: p53 and its downstream genes
Colloids and Surfaces B: Biointerfaces, 2007The tumor-suppressor gene p53 and its downstream genes consist of a complicated gene network. p53 is a key molecular node in the network, which is activated in response to several cellular signals resulting in the maintenance of genetic stability. Several cellular signals may activate the p53 network.
Kun-Xian, Shu, Biao, Li, Li-Xiang, Wu
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p53 Immunoreactivity in oligodendrogliomas
Journal of Neuro-Oncology, 1994Data are presented on p53 protein presence in human oligodendrogliomas whose progress from low grade to anaplastic oligodendroglioma can be followed. Expression was evaluated by formalin-fixed paraffin-embedded section immunohistochemistry, using monoclonal PAb 1801 antibody.
Pavelić, Jasminka +4 more
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Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site
Cancer Cell, 2021Shuo Chen, Li-Li Wu, Ni Yan
exaly
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
Cell, 2021Maya Maor-Nof +2 more
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Mutant p53 suppresses innate immune signaling to promote tumorigenesis
Cancer Cell, 2021Monisankar Ghosh +2 more
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Drugging p53 in cancer: one protein, many targets
Nature Reviews Drug Discovery, 2022Ori Hassin, Moshe Oren, Oren Moshe
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