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Gan to kagaku ryoho. Cancer & chemotherapy, 1997
The gene coding p53 is commonly affected by deletions, rearrangements, or point mutations in a variety of human cancers. p53 is a nuclear phosphoprotein. Mutations are frequently found at highly conserved residues of the p53 protein. The mutant p53 proteins examined so far each have a much longer half-life than that of the wild-type p53 protein which ...
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The gene coding p53 is commonly affected by deletions, rearrangements, or point mutations in a variety of human cancers. p53 is a nuclear phosphoprotein. Mutations are frequently found at highly conserved residues of the p53 protein. The mutant p53 proteins examined so far each have a much longer half-life than that of the wild-type p53 protein which ...
openaire +1 more source
Targeting p53 for the treatment of cancer
Seminars in Cancer Biology, 2022Michael J Duffy +2 more
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Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
Cancer Cell, 2020Chun-Hao Pan +2 more
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A Balancing Act: p53 Activity from Tumor Suppression to Pathology and Therapeutic Implications
Annual Review of Pathology: Mechanisms of Disease, 2022Mengxiong Wang, Laura D Attardi
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p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
Cell, 2019Sung-Hwan Moon +2 more
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A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
Cancer Cell, 2017Stephano S Mello +2 more
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