Results 231 to 240 of about 740,817 (321)

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

A Computational Approach for the Prediction of p53 and BCL-2 Protein-Protein Interactions. [PDF]

Int J Mol Sci
Creamer C, Neely V, Harada H.
europepmc   +1 more source

Treatment of Sk-Mel-28 Cells With r-Moj-DM Upregulates Pro-Apoptotic Genes P53 and TNF-B While Downregulating Oncogene c-Myc

, 2016
Melissa Lombardo
openalex   +2 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Comment on Hasan et al. Clinico-Pathological Features and Immunohistochemical Comparison of p16, p53, and Ki-67 Expression in Muscle-Invasive and Non-Muscle-Invasive Conventional Urothelial Bladder Carcinoma. Clin. Pract. 2023, 13, 806-819. [PDF]

Clin Pract
Harsanyi S, Novakova ZV, Ziaran S, Danisovic L, Bevizova K.   +4 more
europepmc   +1 more source

Glucose Starvation Induces Apoptosis of TSC-/- cells in a p53-dependent Glucose Starvation Induces Apoptosis of TSC-/- cells in a p53-dependent Manner.

, 2009
Chung‐Han Lee
openalex   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway. [PDF]

Front Bioeng Biotechnol
Hu Z, Li F, Hu C, Shan Q, Tang Z, Jiang M, Yi X, Chen X, Jin L, Wang X, Wang Y.   +10 more
europepmc   +1 more source

MOLECULAR ANALYSIS OF THE TP53 R248Q MUTATION: IMPACT ON P53–APR-246 INTERACTION IN AML

LMF Bertoline, K Lima, MFL Carvalho, JA Machado-Neto   +3 more
openalex   +1 more source

A Phase 2 Trial of Surgery With Perioperative INGN 201 (Ad5CMV-p53) Gene Therapy Followed by Chemoradiotherapy for Advanced, Resectable Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, Hypopharynx, and Larynx

, 2009
George H. Yoo, James J. Moon, Michael LeBlanc, Fulvio Lonardo, Susan G. Urba, Harold Kim, Ehab Y. Hanna, Terry Tsue, Joseph Valentino, John F. Ensley, Gregory T. Wolf   +10 more
openalex   +2 more sources