Results 251 to 260 of about 740,817 (321)

The talin1-p53 axis inhibits osteocyte senescence to promote bone mass and mediate skeletal adaptation to mechanical stimulation. [PDF]

Theranostics
Huang J, Qin L, Wang Y, Yan Q, Yang H, Chen H, Wu M, Yi W, Yang J, Lin S, Gong W, Zhang P, He S, Zhang X, Xiao G.   +14 more
europepmc   +1 more source

Polo‐like kinase 1 phosphorylation of G2 and S‐phase‐expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery

, 2010
X. Shawn Liu, Hongchang Li, Bing Song, Xiaoqi Liu   +3 more
openalex   +2 more sources

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

MDM2 in Tumor Biology and Cancer Therapy: A Review of Current Clinical Trials. [PDF]

Int J Mol Sci
Russano F, Sturlese M, Dall'Olmo L, Callegarin F, Brugnolo D, Del Fiore P, Patti V, Purpura A, Moro S, Rastrelli M, Mocellin S.   +10 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Expression of p53, p21, STAT3 and Cyclin D1 in cirrhosis phase of hepatocarcinoma in a rat model carrying abnormal savda

, 2014
Helim Resalat, Abduwayit Resalat, Upur Halmurat, Yanjiao Wang, Abdurhem Ayupjan, Mamtimin Imam, Bakri Iskandar   +6 more
openalex   +1 more source

Gut Microbe‐Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Advanced Science, EarlyView.
Acinetobacter regulates dinotefuran tolerance in Propylea japonica by mediating the expression of the horizontally transferred gene PjDUF1. Abstract Insect–microbial symbiont relationships are widespread in nature and often involve lateral gene transfer.
Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao   +10 more
wiley   +1 more source

<i>Rps19</i> ^R67∆ mutation creates a model of Diamond-Blackfan anemia and reveals downstream mediators of p53 pathway. [PDF]

Hemasphere
Kokavec J, Turková T, Schuster B, Prochazka J, Spoutil F, Jamrichová K, Holečková M, Chalupský K, Beck IM, Ruberte J, Vale M, Čermák L, Stopka T, Sedlacek R.   +13 more
europepmc   +1 more source

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine

Advanced Science, EarlyView.
An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu, Xiaoyue Xu, Dan Xu, Hui Zhang, Nan Wang, Yang Yang, Qian Chen, Shunjie Chen, Cheng Li   +8 more
wiley   +1 more source