Results 251 to 260 of about 101,614 (324)

Integrative Single‐Cell Analysis Reveals Targetable Vacuole Membrane Protein 1‐Mediated Mechanism of Tumor Angiogenesis in Glioblastoma

MedComm, Volume 7, Issue 2, February 2026.
VMP1 promotes angiogenesis in glioblastoma (GBM) through VEGFA‐VEGFR2 signaling and activation of endothelial cells. The FDA‐approved anti‐VEGFA antibody, bevacizumab (BEV), can counteract VMP1's tumor‐promoting effect in GBM. Targeting VMP1 or its associated pathways could be a new therapeutic strategy, either alone or in combination with BEV.
Lei Jin, Bo Chen, Junbo Liao, Wenlong Guo, Zhiyuan Zhu, Salida Ali, Gilberto Ka‐Kit Leung, Peng Wang, Karrie M. Kiang   +8 more
wiley   +1 more source

Developments in the Economics of Aging [PDF]

Courtney Coile
core   +3 more sources

AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity. [PDF]

Cell Mol Life Sci
Fassett EK, Mayer B, Fassett JT.
europepmc   +1 more source

RCC1 Domain‐Containing Protein 1 Promotes Colon Cancer Malignant Progression by Activating Autophagy‐Dependent WNT5A Secretion in Cancer‐Associated Fibroblasts

Journal of the Royal Society of New Zealand, Volume 56, Issue 1, February 2026.
RCCD1 is upregulated in colon cancer and cancer‐associated fibroblasts (CAFs). In CAFs, RCCD1 overexpression activates AMPK/mTOR/ULK1 signaling, enhancing autophagy. This stimulates autophagic secretion of WNT5A. WNT5A then activates the nonclassical Wnt/CaMKII/ERK pathway in tumor cells, promoting epithelial‐mesenchymal transition (EMT), proliferation,
Chao Liu, Sheng Xu, Yuanyuan Liu, Yuntian Tang   +3 more
wiley   +1 more source

Antigen B from Echinococcus granulosus regulates autophagy-mediated macrophage polarization to alleviate immune thrombocytopenia. [PDF]

Parasit Vectors
Song HC, Li DL, Wang JJ, Jiao HJ, Li MW, Zhao L, Yang XH, Yan M.   +7 more
europepmc   +1 more source

p62/SQSTM1 Plays a Protective Role in Oxidative Injury of Steatotic Liver in a Mouse Hepatectomy Model

, 2014
Sanae Haga, Takeaki Ozawa, Yuma Yamada, Naoki Morita, I Nagashima, Hiroshi Inoue, Y. Inaba, Natsumi Noda, Riichiro Abe, Kazuo Umezawa, Michitaka Ozaki   +10 more
openalex   +2 more sources

Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
Denervation induces mitochondrial dysfunction and oxidative stress in skeletal muscle. In PolG(+/mut) mice, denervation led to reduced mitochondrial DNA copy number and a pronounced upregulation of the antioxidant enzyme catalase, despite comparable levels of muscle atrophy, mitochondrial content, and mitochondrial dynamics‐related proteins compared to
Takanaga Shirai, Hideto Hanakita, Kohei Takeda, Yu Kitaoka, Kaori Ishikawa, Kazuto Nakada, Tohru Takemasa   +6 more
wiley   +1 more source

Haematococcus pluvialis ameliorates renal fibrosis by restoring mitophagy via PINK1-Parkin-p62-LC3 signaling. [PDF]

NPJ Sci Food
Wu Y, Chen C, Xie J, Chang X, Zhang Y, Zheng Y, Yuan Y, Hu W, Xie X.   +8 more
europepmc   +1 more source

Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis

, 2014
Yasuo Shimizu, Kunio Dobashi, Hiroyuki Nagase, Ken Ohta, Takaaki Sano, Shinichi Matsuzaki, Yoshiki Ishii, Takahiro Satoh, Masashi Koka, Akihito Yokoyama, Takeru Ohkubo, Yasuyuki Ishii, Tomihiro Kamiya   +12 more
openalex   +2 more sources

Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state

Acta Crystallographica Section D, Volume 82, Issue 2, Page 140-150, February 2026.
Structural characterization of S. mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state and identifies a schistosome‐specific epitope.Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino‐acid ...
Kelly L. Parker, John D. Clarke, Xiaojiao Liu, Barbara F. Gomes, Lauren E.-A. Eyssen, Nicholas Furnham, Floriano Paes Silva-Jr, Raymond J. Owens   +7 more
wiley   +1 more source