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S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy

Molecular Cell, 2023
p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. p62 promotes the assembly and removal of ubiquitinated proteins by forming p62-liquid droplets. However, it remains unclear how autophagosomes efficiently sequester p62 droplets.
Dante Neculai, Aimin Yang, Eryan Kong
exaly   +5 more sources

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Interaction Domains of p62: A Bridge Between p62 and Selective Autophagy

DNA and Cell Biology, 2013
p62 is a multidomain protein that contains different kinds of protein-protein interaction domains, including an N-terminal PB1 domain, a ZZ-type zinc finger domain, a nuclear localization signal (NLS), an export motif (NES), the LC3-interacting region (LIR), the KEAP1-interacting region (KIR), and a C-terminal Ub-associated domain (UBA).
Xiaolong, Lin, Shuang, Li, Yue, Zhao, Xiaofeng, Ma, Kai, Zhang, Xinglan, He, Zuo, Wang   +6 more
openaire   +2 more sources

p62 in Cancer: Signaling Adaptor Beyond Autophagy [PDF]

Cell, 2016
Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.
Jorge Moscat, Michael Karin, Maria Diaz-Meco   +2 more
exaly   +5 more sources

Sequestosome 1/p62: across diseases

Biomarkers, 2012
Sequestosome 1/p62 is a signal modulator or adaptor protein involved in receptor-mediated signal transduction. Sequestosome 1/p62 is gaining attention as it is involved in several diseases including Parkinson disease, Alzheimer disease, liver and breast cancer, Paget's disease of bone, obesity and insulin resistance.
Thangiah, Geetha, Nilmini, Vishwaprakash, Marina, Sycheva, Jeganathan Ramesh, Babu   +3 more
openaire   +2 more sources

Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation

Molecular Neurobiology, 2013
Mutations in presenilin-1 (PS1) are tightly associated with early-onset familial Alzheimer's disease (FAD), which is characterized by extracellular amyloid plaques and the accumulation of intracellular Tau. In addition to being the catalytic subunit of γ-secretase, PS1 has been shown to regulate diverse cellular functions independent of its proteolytic
Ying-Tsen, Tung, Bo-Jeng, Wang, Wen-Ming, Hsu, Ming-Kuan, Hu, Guor Mour, Her, Wei-Pang, Huang, Yung-Feng, Liao   +6 more
openaire   +2 more sources

Feedback on Fat: p62-mTORC1-Autophagy Connections [PDF]

Cell, 2011
Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control.
Jorge Moscat, Maria Diaz-Meco
exaly   +3 more sources