Results 121 to 130 of about 6,861 (141)

Enhancing Efficacy of Albumin-Bound Paclitaxel for Human Lung and Colorectal Cancers through Autophagy Receptor Sequestosome 1 (SQSTM1)/p62-Mediated Nanodrug Delivery and Cancer therapy

ACS Nano, 2023
Selective autophagy is a defense mechanism by which foreign pathogens and abnormal substances are processed to maintain cellular homeostasis. Sequestosome 1 (SQSTM1)/p62, a vital selective autophagy receptor, recruits ubiquitinated cargo to form autophagosomes for lysosomal degradation.
Jui-I Chao
exaly   +3 more sources

Sequestosome 1 (SQSTM1/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture

Neuroscience Letters, 2017
Sequestosome 1 (SQSTM1) also known as ubiquitin-binding protein p62 (p62) is a cargo protein involved in the degradation of misfolded proteins via selective autophagy. Disruption of autophagy and resulting accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress.
Motomitsu Gotō, Yoshiaki Morishita, Yoshihiro Itô   +2 more
exaly   +3 more sources

Sequestosome 1 (SQSTM1; p62)

Science-Business eXchange, 2009
openaire   +1 more source

The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity

Autophagy, 2020
Chuanxin Huang
exaly  

SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling

Neurobiology of Aging, 2021
Qian Nie, Jing Cui, Liang Li
exaly  

USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes

Free Radical Biology and Medicine, 2023
Bin Lee, Young Hun Kim, Woori Lee
exaly  

Faculty Opinions recommendation of Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2014
openaire   +1 more source

Immunohistochemical expression of autophagy-related-protein p62/SQSTM1/Sequestosome-1 in primary and recurrent glioblastomas of the central nervous system: is there any relationship with targeted-therapy and patient's outcome?

p62/SQSTM1/Sequestosome‐1 is an autophagic protein of fundamental importance in cellular metabolism and tumor proliferatio. Moreover, autophagy may influence the development and resistance to therapy of numerous types of human cancer. In the present pilot study, the immunohistochemical expression of p62 was analyzed in a cohort of primary and recurrent
openaire   +1 more source

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

Autophagy, 2014
Eisuke Itakura, Noboru Mizushima
exaly  

Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling

Autophagy, 2013
Junyan Shi, Paulina Piesik, Gabriel Fung   +2 more
exaly