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The biological functions and signaling mechanisms of the p75 neurotrophin receptor.
Handbook of Experimental Pharmacology, 2014The p75 neurotrophin receptor (p75(NTR)) regulates a wide range of cellular functions, including programmed cell death, axonal growth and degeneration, cell proliferation, myelination, and synaptic plasticity. The multiplicity of cellular functions governed by the receptor arises from the variety of ligands and co-receptors which associate with p75(NTR)
B. R. Kraemer +4 more
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p75 Neurotrophin receptor signaling in the nervous system
2004The neurotrophin receptor p75(NTR) has long been known as a receptor for neurotrophins that promote survival and differentiation. Consistent with the role of neurotrophins, p75(NTR) is expressed during the developmental stages of the nervous system. However, p75(NTR) is re-expressed in various pathological conditions in the adult.
Yuiko, Hasegawa +3 more
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The p75 neurotrophin receptor in human development and disease
Progress in Neurobiology, 2005The functional effects of nerve growth factor (NGF) and its precursor, pro-NGF, are thought to be mediated through binding of these ligands to one or both of their receptors, TrkA and p75NTR. While the signaling pathways and downstream effects of NGF binding to TrkA are reasonably well known, those related to the binding of NGF and pro-NGF to p75NTR ...
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Small Molecule Modulation of p75 Neurotrophin Receptor Functions
CNS & Neurological Disorders - Drug Targets, 2008Ligand-independent and/or proNGF-induced p75(NTR) signaling has emerged as a potential major contributor to a number of pathological states, including axotomy-induced death, motor neuron degeneration, neuronal degeneration in Alzheimer's disease and oligodendrocyte death following spinal cord injury.
Frank Longo +3 more
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Signaling of the neurotrophin receptor p75 in relation to Alzheimer’s disease
Biochemical and Biophysical Research Communications, 2009The cellular mechanism of neuronal apoptosis in Alzheimer's disease (AD) is poorly understood. Many hypotheses have been put fourth to explain the underlying reason for neuro-degeneration in AD. Here, it is demonstrated that all neurotrophins that activated p75, without co-activation of the relevant Trk co-receptor, mediated apoptosis in hippocampal ...
Adama, Diarra +3 more
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p75 neurotrophin receptor as a modulator of survival and death decisions
Microscopy Research and Technique, 1999The p75 receptor is the founding member of the TNF receptor superfamily. Members in this receptor family share a common cysteine motif repeated two to six times that serves as the ligand binding domain. In addition, several members contain a cytoplasmic region designated the death domain. The neurotrophins NGF, BDNF, NT-3, and NT-4 each bind to the p75
P, Casaccia-Bonnefil +3 more
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Coupling of the p75 Neurotrophin Receptor to Sphingolipid Signalinga
Annals of the New York Academy of Sciences, 1998ABSTRACT:The neurotrophins are a family of growth factors involved in the survival and differentiation of specific populations of neurons and glial cells. Many of the trophic signals elicited by neurotrophins are initiated by the binding of these molecules to various Trk tyrosine kinase receptors.
R T, Dobrowsky, B D, Carter
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The role of neurotrophins in bronchial asthma: contribution of the pan-neurotrophin receptor p75
2004Allergic bronchial asthma is characterized by chronic inflammation of the airways, development of airway hyperreactivity and recurrent reversible airway obstruction. Target and effector cells responsible for airway hyperresponsiveness and airway obstruction include sensory and motor neurons as well as epithelial and smooth muscle cells.
Harald, Renz +2 more
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p75 Neurotrophin receptor immunoreactivity in the aged human hypothalamus
Neuroscience Letters, 1997Low-affinity p75 neurotrophin receptor (p75NTR) immunoreactivity in the aged human hypothalamus was examined in autopsied material. Numerous p75NTR-immunoreactive cells were found in the paraventricular and supraoptic hypothalamic nuclei. The suprachiasmatic nucleus was devoid of p75NTR-immunostaining.
M M, Moga, T, Duong
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