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Neurotrophin signaling through the p75 neurotrophin receptor
Progress in Neurobiology, 2002The neurotrophins are growth factors that play critical roles in the development, maintenance, survival, and death of the nervous system. The signal transducing systems that mediate the diverse biological functions of the neurotrophins are initiated by their interactions with two categories of cell surface receptors, the Trk family of tyrosine kinases ...
Pierre Roux +2 more
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Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System [PDF]
Journal of International Medical Research, 2009 The p75 neurotrophin receptor (p75NTR) is a transmembrane protein that binds nerve growth factor (NGF) and has multiple functions in the nervous system where it is expressed widely during the developmental stages of life, although expression decreases dramatically by adulthood. Expression of p75NTR can increase in pathological states related to neural
Ling-Ping Cen
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The p75 neurotrophin receptor and neuronal apoptosis
Progress in Neurobiology, 2000Although evidence continues to accumulate for the apoptosis-inducing role of the p75 neurotrophin receptor, several outstanding questions remain. One of these concerns the signal transduction pathway of p75, which continues to be elusive. The evidence for the roles of ceramide, c-jun kinase and NF-kappaB is discussed: none of these are able to account ...
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The International Journal of Biochemistry & Cell Biology, 2008
The pan neurotrophin receptor (p75(NTR)) is best known for mediating neural cell death during development as well as in the adult following injury, the latter making it a target for the treatment of neurodegenerative disease. Although p75(NTR) has been studied for over 30 years, a number of recent discoveries have changed our understanding of its ...
Underwood, Clare K. +1 more
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The pan neurotrophin receptor (p75(NTR)) is best known for mediating neural cell death during development as well as in the adult following injury, the latter making it a target for the treatment of neurodegenerative disease. Although p75(NTR) has been studied for over 30 years, a number of recent discoveries have changed our understanding of its ...
Underwood, Clare K. +1 more
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Diverse functions of the p75 neurotrophin receptor
Anatomical Science International, 2005The pan-neurotrophin receptor p75NTR belongs to a large family of receptors, which includes tumor necrosis factor receptors, Fas and approximately 25 other members. The p75NTR is the first receptor to be cloned molecularly. Recent years have seen the emergence of a consensus regarding the signaling pathways activated by p75NTR and its potential ...
Toshihide, Yamashita +4 more
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NMR structure of the death domain of the p75 neurotrophin receptor [PDF]
EMBO Journal, 1997 The intracellular domain of the p75 neurotrophin receptor (p75ICD) lacks catalytic activity but contains a motif similar to death domains found in the cytoplasmic regions of members of the tumor necrosis factor receptor family and their downstream targets.
Gottfried Otting +2 more
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Biological Reviews of The Cambridge Philosophical Society, 2019
The death domain (DD) is a globular protein motif with a signature feature of an all‐helical Greek‐key motif. It is a primary mediator of a variety of biological activities, including apoptosis, cell survival and cytoskeletal changes, which are related ...
Wensu Yuan, C. Ibáñez, Zhi Lin
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The death domain (DD) is a globular protein motif with a signature feature of an all‐helical Greek‐key motif. It is a primary mediator of a variety of biological activities, including apoptosis, cell survival and cytoskeletal changes, which are related ...
Wensu Yuan, C. Ibáñez, Zhi Lin
semanticscholar +1 more source
Inactivation and activation of Ras by the neurotrophin receptor p75
European Journal of Neuroscience, 2004AbstractThe neurotrophin receptor p75 induces neurotrophic and/or apoptotic signalling pathways and can also cooperate with the neurotrophic Trk receptor tyrosine kinases. Its intracellular part encloses a so‐called ‘death domain’ with a segment similar to the wasp venom mastoparan which binds small GTPases such as Rho.
Blöchl, A. +2 more
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Journal of Neurobiology, 1994
AbstractThe low‐affinity p75 molecule and trk tyrosine kinases serve as receptors for target‐derived neurotrophins. While the mechanism by which receptor tyrosine kinases impart intracellular signaling has become well understood, the precise roles of the p75 receptor are not fully defined.
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AbstractThe low‐affinity p75 molecule and trk tyrosine kinases serve as receptors for target‐derived neurotrophins. While the mechanism by which receptor tyrosine kinases impart intracellular signaling has become well understood, the precise roles of the p75 receptor are not fully defined.
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p75 Neurotrophin receptor signaling
Journal of Neuroscience Research, 2000The recent recognition that the p75 neurotrophin receptor, p75((NTR)), can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75(NTR) signaling remain to be fully characterized, many of the currently identified pathways activated by p75(NTR) may be generally ...
R T, Dobrowsky, B D, Carter
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