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The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor
2014The p75 neurotrophin receptor (p75(NTR)) regulates a wide range of cellular functions, including programmed cell death, axonal growth and degeneration, cell proliferation, myelination, and synaptic plasticity. The multiplicity of cellular functions governed by the receptor arises from the variety of ligands and co-receptors which associate with p75(NTR)
B R, Kraemer, S O, Yoon, B D, Carter
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p75 Neurotrophin receptor immunoreactivity in the aged human hypothalamus
Neuroscience Letters, 1997Low-affinity p75 neurotrophin receptor (p75NTR) immunoreactivity in the aged human hypothalamus was examined in autopsied material. Numerous p75NTR-immunoreactive cells were found in the paraventricular and supraoptic hypothalamic nuclei. The suprachiasmatic nucleus was devoid of p75NTR-immunostaining.
M M, Moga, T, Duong
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CD 271 (P75 neurotrophin receptor).
Journal of biological regulators and homeostatic agents, 2008P75NTR (or CD271) is a member of the Tumor Necrosis Factor receptor (TNFR) super family of transmembrane proteins that share significant homology in their extracellular domains. Subsets of TNF receptors, including CD271, have a cytoplasmic death domain, although CD271 has unique intracellular structure and downstream signaling partners.
Rogers, M. +3 more
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The p75 neurotrophin receptor: multiple interactors and numerous functions
2004The neurotrophin receptor p75 (p75NTR), is involved in a diverse array of cellular responses, including apoptosis, neurite outgrowth and myelination. Stimulation of p75NTR with neurotrophin can activate multiple downstream signals, including the small GTP binding protein Rac, the transcription factor NF-kappa B and the stress activated kinase, JNK. How
Jannifer J, Gentry +2 more
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Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?
Ageing Research Reviews, 2022Sreedharan Sajikumar +2 more
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The low affinity neurotrophin receptor, p75
2010I A Ferguson, J J Lu, X F Zhou, R A Rush
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c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination
Cellular Signalling, 2004Teruko Tamura +2 more
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Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders: Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2001
Simon Murray, S S Cheema
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Simon Murray, S S Cheema
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