Results 221 to 230 of about 14,891 (243)

Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies

Current Alzheimer Research, 2017
The p75 neurotrophin receptor (p75NTR) is a single membrane-spanning receptor in the tumor necrosis factor (TNF) death domain containing receptor family. p75NTR has multiple faces of biological or pathogenic functions by partnering with the three major neurotrophin receptors, including tropomyosin receptor kinase (Trk), sortilin and Nogo receptors.
Changyue, Gao, Lili, Zhang, Dayu, Sun, Jingcheng, Li, Xiuqing, Yao, Huadong, Zhou, Yanjiang, Wang   +6 more
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The function of p75NTR in glia

Trends in Neurosciences, 2008
The p75 neurotrophin receptor (p75(NTR)) is expressed on many cell types and can influence a variety of cellular functions. This receptor can mediate cell survival or cell death, can promote or inhibit axonal growth and can facilitate or attenuate proliferation, depending on the cell context.
Andrea B, Cragnolini, Wilma J, Friedman
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Roles of glial p75NTR in axonal regeneration

Journal of Neuroscience Research, 2007
AbstractThe neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up‐regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin‐associated proteins resulting in neurite collapse, glial p75NTR may play a positive role in nerve ...
Zhou, Xin-Fu, Li, Hong-Yun
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p75NTR is Independently Deadly

Science Signaling, 2002
Neurotrophins, such as nerve growth factor (NGF), can interact with two classes of receptors: the receptor tyrosine kinases Trk receptors or the death-domain receptor p75NTR. Binding to the Trk receptors mediates cell survival signals and is also important for cell development and differentiation.
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p75NTR: A study in contrasts

Cell Death & Differentiation, 1998
The p75 neurotrophin receptor (p75NTR) and trkA, trkB and trkC mediate the physiological effects of the neurotrophins. The trk receptors are responsible for the stereotypical survival and growth properties of the neurotrophins but defining the physiological function of the p75NTR has proven difficult. The p75NTR binds each of the neurotrophins with low
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p75NTR and Sortilin Increase After Facial Nerve Injury

The Laryngoscope, 2008
AbstractObjectives: After axotomy, Schwann cells (SCs), required for successful nerve regeneration, undergo a number of cellular changes including dedifferentiation, proliferation, expression of molecules that support axon growth, and apoptosis. This study investigated the role of p75NTR, sortilin, and proneurotrophins in SC survival after facial nerve
Matthew J, Provenzano, Ningyong, Xu, Mark R, Ver Meer, J Jason, Clark, Marlan R, Hansen   +4 more
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The many faces of p75NTR

Current Opinion in Neurobiology, 2002
The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new ...
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RanBPM is a novel binding protein for p75NTR

Biochemical and Biophysical Research Communications, 2003
The neurotrophin receptor p75NTR can induce signal transduction both in vivo and in vitro. The mechanisms by which p75NTR transduces signals have remained mostly unknown. Using yeast two-hybrid system, we identified the Ran-binding protein (RanBPM) as an interactor with the intracytoplasmic domain of p75NTR (p75ICD).
Dong, Bai, Hong, Chen, Bing-Ren, Huang
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p75NTR as a Therapeutic Target for Neuropsychiatric Diseases

Current Molecular Pharmacology, 2009
The p75 neurotrophin receptor (p75NTR) was originally identified as a low-affinity receptor for neurotrophins. Recent studies have revealed that p75NTR can promote cell death or survival and modulate neurite outgrowth depending on the operative ligands and co-receptors.
Takashi, Fujii, Hiroshi, Kunugi
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