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Heparanase Expression and TrkC/p75NTR Ratios in Human Medulloblastoma
Clinical & Experimental Metastasis, 2006Medulloblastoma (MB), the most devastating and common brain tumor in children, is highly invasive and extremely difficult to treat. Identifying the properties of MB tumors that cause them to invade and metastasize is therefore imperative for the development of novel treatments.
Neeta D, Sinnappah-Kang +3 more
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Dynamic Structure of NGF and proNGF Complexed with p75NTR: Pro-Peptide Effect
Journal of Chemical Information and Modeling, 2014Crystallographic structures of NGF/p75NTR and proNGF/p75NTR were previously obtained in 2:1 and 2:2 stoichiometries, respectively. However, evidence shows that both stoichiometries can occur for mature neurotrophins and pro-neurotrophins. We used Molecular Dynamics (MD) simulations to examine the energetic and structural characteristics of these two ...
António César Pimenta +7 more
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TrkA NGF receptor plays a role in the modulation of p75NTR expression
Neuroscience Letters, 2005The cellular response to nerve growth factor (NGF) is mediated by two structurally unrelated receptors, TrkA and p75 neurotrophin receptor (p75NTR), which have been shown to interact resulting in reciprocal modulation of function. In this study, we have examined the modulation of p75NTR protein expression by specific TrkA autophosphorylation sites in ...
Sherri L, Rankin +2 more
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Enhanced pro-BDNF-p75NTR pathway activity in denervated skeletal muscle
Life Sciences, 2021Ryan Antony +2 more
exaly
Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF
Cell Death and Differentiation, 1999Dale E Bredesen
exaly