Results 191 to 200 of about 14,094 (223)
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Roles of p75NTR in the pathogenesis of Alzheimer's disease: A novel therapeutic target
Biochemical Pharmacology, 2011Alzheimer's disease (AD), the most common form of dementia, is characterized by the deposition of amyloid plaques, accumulation of fibrillary tangles in neurons, neurite degeneration, loss of neurons, and a progressive loss of cognitive function. The pathogenesis of AD is not fully understood, and no strong disease-modifying therapies are currently ...
Fan Zeng +2 more
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Der Neurotrophinrezeptor p75NTR
20020 Titelblatt 1 1 Zusammenfassung 9 2 Abstract 10 3 Einleitung 11 3.1 Biologische Funktion der Neurotrophine 11 3.2 Struktur der Neurotrophine 13 3.3 Die Rezeptoren der Neurotrophine 14 3.3.1 Die Trk Rezeptoren 15 3.3.2 Der Neurotrophinrezeptor p75NTR 16 4 Zielsetzung der Arbeit 21 4.1 Reinigung von intrazellulären Interaktoren 21 4.1.1 Experimentelle ...
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Signaling of neuronal cell death by the p75NTR neurotrophin receptor
Molecular Neurobiology, 1999The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes with trkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently of trkA.
Coulson, E. J. +2 more
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p75NTR and Sortilin Increase After Facial Nerve Injury
The Laryngoscope, 2008AbstractObjectives: After axotomy, Schwann cells (SCs), required for successful nerve regeneration, undergo a number of cellular changes including dedifferentiation, proliferation, expression of molecules that support axon growth, and apoptosis. This study investigated the role of p75NTR, sortilin, and proneurotrophins in SC survival after facial nerve
Matthew J, Provenzano +4 more
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ProBDNF-p75NTR signaling in sterile inflammation
PhysiologyTrauma, injury, and surgical procedures cause tissue damage, sterile inflammatory responses, and significant immune system stress leading to immune dysregulation and increased susceptibility to secondary infections. The spleen is a reservoir of myeloid immune cells that are involved in inflammation following various tissue injuries.
Katherine Aby, Ryan Antony, Yifan Li
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Deletion of p75NTR impairs regeneration of peripheral nerves in mice
Life Sciences, 2009After peripheral nerve injury, p75NTR was upregulated in Schwann cells of the Wallerian degenerative nerves and in motor neurons but down-regulated in the injured sensory neurons. As p75NTR in neurons mediates signals of both neurotrophins and inhibitory factors, it is regarded as a therapeutic target for the treatment of neurodegeneration.
Zhang, Feng-He +4 more
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Regulation and function of P75NTR
2012The p75 neurotrophin receptor (p75NTR) has been known to play multiple roles in cell survival and apoptosis (Friedman, 2000; Maggirwar et al., 1998; Rabizadeh et al., 1993), axonal growth (Bentley and Lee, 2000), and cell differentiation (Hosomi et al., 2003).
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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex
Nature, 2008Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT.
Yong, Gong +3 more
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p75NTR and apoptosis: Trk-dependent and Trk-independent effects
Trends in Neurosciences, 1997The ongoing dissection of the roles of p75NTR and TrkA, -B and -C in neurotrophin signaling has generated a number of apparent paradoxes. Limiting consideration to the role of p75NTR in cell death, a theory is proposed that is based on the following postulates: (1) that p75NTR displays a pro-apoptotic intrinsic (ligand-independent, Trk-independent ...
D E, Bredesen, S, Rabizadeh
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