Results 181 to 190 of about 14,094 (223)
Some of the next articles are maybe not open access.
Roles of glial p75NTR in axonal regeneration
Journal of Neuroscience Research, 2007AbstractThe neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up‐regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin‐associated proteins resulting in neurite collapse, glial p75NTR may play a positive role in nerve ...
Xiaofang Zhou, Hongyun Li
exaly +4 more sources
The function of p75NTR in glia
Trends in Neurosciences, 2008The p75 neurotrophin receptor (p75(NTR)) is expressed on many cell types and can influence a variety of cellular functions. This receptor can mediate cell survival or cell death, can promote or inhibit axonal growth and can facilitate or attenuate proliferation, depending on the cell context.
Andrea B, Cragnolini, Wilma J, Friedman
openaire +2 more sources
Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies
Current Alzheimer Research, 2017The p75 neurotrophin receptor (p75NTR) is a single membrane-spanning receptor in the tumor necrosis factor (TNF) death domain containing receptor family. p75NTR has multiple faces of biological or pathogenic functions by partnering with the three major neurotrophin receptors, including tropomyosin receptor kinase (Trk), sortilin and Nogo receptors.
Changyue, Gao +6 more
openaire +2 more sources
Current Opinion in Neurobiology, 2005
During neuronal development, neurotrophins are essential factors that promote survival, differentiation and myelination of neurons. The trophic signals are relayed to the cells via binding to Trk receptor tyrosine kinases and the p75 neurotrophin receptor.
Anders, Nykjaer +2 more
openaire +2 more sources
During neuronal development, neurotrophins are essential factors that promote survival, differentiation and myelination of neurons. The trophic signals are relayed to the cells via binding to Trk receptor tyrosine kinases and the p75 neurotrophin receptor.
Anders, Nykjaer +2 more
openaire +2 more sources
RanBPM is a novel binding protein for p75NTR
Biochemical and Biophysical Research Communications, 2003The neurotrophin receptor p75NTR can induce signal transduction both in vivo and in vitro. The mechanisms by which p75NTR transduces signals have remained mostly unknown. Using yeast two-hybrid system, we identified the Ran-binding protein (RanBPM) as an interactor with the intracytoplasmic domain of p75NTR (p75ICD).
Dong, Bai, Hong, Chen, Bing-Ren, Huang
exaly +3 more sources
p75NTR as a Therapeutic Target for Neuropsychiatric Diseases
Current Molecular Pharmacology, 2009The p75 neurotrophin receptor (p75NTR) was originally identified as a low-affinity receptor for neurotrophins. Recent studies have revealed that p75NTR can promote cell death or survival and modulate neurite outgrowth depending on the operative ligands and co-receptors.
Takashi, Fujii, Hiroshi, Kunugi
openaire +2 more sources
Signalling through the neurotrophin receptor p75NTR
Current Opinion in Neurobiology, 1997Activation specific tyrosine kinase receptors by neurotrophins accounts for the longest known biological actions of the neurotrophins, in particular the promotion of neuronal survival. However, recent studies have revealed that nerve growth factor, the neurotrophin regarded as best understood, also activates a signalling pathway by binding to the ...
Dechant, G., Barde, Y. A.
openaire +2 more sources
Cell Death & Differentiation, 1998
The p75 neurotrophin receptor (p75NTR) and trkA, trkB and trkC mediate the physiological effects of the neurotrophins. The trk receptors are responsible for the stereotypical survival and growth properties of the neurotrophins but defining the physiological function of the p75NTR has proven difficult. The p75NTR binds each of the neurotrophins with low
openaire +2 more sources
The p75 neurotrophin receptor (p75NTR) and trkA, trkB and trkC mediate the physiological effects of the neurotrophins. The trk receptors are responsible for the stereotypical survival and growth properties of the neurotrophins but defining the physiological function of the p75NTR has proven difficult. The p75NTR binds each of the neurotrophins with low
openaire +2 more sources
p75NTR is Independently Deadly
Science Signaling, 2002Neurotrophins, such as nerve growth factor (NGF), can interact with two classes of receptors: the receptor tyrosine kinases Trk receptors or the death-domain receptor p75NTR. Binding to the Trk receptors mediates cell survival signals and is also important for cell development and differentiation.
openaire +2 more sources
Current Opinion in Neurobiology, 2002
The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new ...
openaire +2 more sources
The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new ...
openaire +2 more sources