Results 171 to 180 of about 9,698 (210)
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p75NTR is Independently Deadly
Science Signaling, 2002Neurotrophins, such as nerve growth factor (NGF), can interact with two classes of receptors: the receptor tyrosine kinases Trk receptors or the death-domain receptor p75NTR. Binding to the Trk receptors mediates cell survival signals and is also important for cell development and differentiation.
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Signalling through the neurotrophin receptor p75NTR
Current Opinion in Neurobiology, 1997Activation specific tyrosine kinase receptors by neurotrophins accounts for the longest known biological actions of the neurotrophins, in particular the promotion of neuronal survival. However, recent studies have revealed that nerve growth factor, the neurotrophin regarded as best understood, also activates a signalling pathway by binding to the ...
Dechant, G., Barde, Y. A.
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Cell Death & Differentiation, 1998
The p75 neurotrophin receptor (p75NTR) and trkA, trkB and trkC mediate the physiological effects of the neurotrophins. The trk receptors are responsible for the stereotypical survival and growth properties of the neurotrophins but defining the physiological function of the p75NTR has proven difficult. The p75NTR binds each of the neurotrophins with low
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The p75 neurotrophin receptor (p75NTR) and trkA, trkB and trkC mediate the physiological effects of the neurotrophins. The trk receptors are responsible for the stereotypical survival and growth properties of the neurotrophins but defining the physiological function of the p75NTR has proven difficult. The p75NTR binds each of the neurotrophins with low
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Current Opinion in Neurobiology, 2002
The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new ...
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The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new ...
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Der Neurotrophinrezeptor p75NTR
20020 Titelblatt 1 1 Zusammenfassung 9 2 Abstract 10 3 Einleitung 11 3.1 Biologische Funktion der Neurotrophine 11 3.2 Struktur der Neurotrophine 13 3.3 Die Rezeptoren der Neurotrophine 14 3.3.1 Die Trk Rezeptoren 15 3.3.2 Der Neurotrophinrezeptor p75NTR 16 4 Zielsetzung der Arbeit 21 4.1 Reinigung von intrazellulären Interaktoren 21 4.1.1 Experimentelle ...
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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex
Nature, 2008Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT.
Yong, Gong +3 more
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p75NTR and Sortilin Increase After Facial Nerve Injury
The Laryngoscope, 2008AbstractObjectives: After axotomy, Schwann cells (SCs), required for successful nerve regeneration, undergo a number of cellular changes including dedifferentiation, proliferation, expression of molecules that support axon growth, and apoptosis. This study investigated the role of p75NTR, sortilin, and proneurotrophins in SC survival after facial nerve
Matthew J, Provenzano +4 more
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ProBDNF-p75NTR signaling in sterile inflammation
PhysiologyTrauma, injury, and surgical procedures cause tissue damage, sterile inflammatory responses, and significant immune system stress leading to immune dysregulation and increased susceptibility to secondary infections. The spleen is a reservoir of myeloid immune cells that are involved in inflammation following various tissue injuries.
Katherine Aby, Ryan Antony, Yifan Li
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p75NTR and apoptosis: Trk-dependent and Trk-independent effects
Trends in Neurosciences, 1997The ongoing dissection of the roles of p75NTR and TrkA, -B and -C in neurotrophin signaling has generated a number of apparent paradoxes. Limiting consideration to the role of p75NTR in cell death, a theory is proposed that is based on the following postulates: (1) that p75NTR displays a pro-apoptotic intrinsic (ligand-independent, Trk-independent ...
D E, Bredesen, S, Rabizadeh
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