Results 61 to 70 of about 1,463,960 (261)

Conformal (p, q) supergeometries in two dimensions

Journal of High Energy Physics, 2023
We propose a superspace formulation for conformal (p, q) supergravity in two dimensions as a gauge theory of the superconformal group OSp0(p|2; ℝ) × OSp0(q|2; ℝ) with a flat connection.
Sergei M. Kuzenko, Emmanouil S. N. Raptakis   +1 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A certain class of deferred weighted statistical B-summability involving (p,q)-integers and analogous approximation theorems

Filomat, 2019
The preliminary idea of statistical weighted B-summability was introduced by Kadak et al. [27]. Subsequently, deferred weighted statistical B-summability has recently been studied by Pradhan et al. [38]. In this paper, we study statistical versions of deferred weighted B-summability as well as deferred weighted B-convergence with respect to
Zraiqat, Amjed, Paikray, S. K., Dutta, Hemen   +2 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Some approximation properties of ( p , q ) $(p,q)$ -Bernstein operators

Journal of Inequalities and Applications, 2016
This paper is concerned with the ( p , q ) $(p,q)$ -analog of Bernstein operators. It is proved that, when the function is convex, the ( p , q ) $(p,q)$ -Bernstein operators are monotonic decreasing, as in the classical case.
Shin Min Kang, Arif Rafiq, Ana-Maria Acu, Faisal Ali, Young Chel Kwun   +4 more
doaj   +1 more source

Some approximation results on Bernstein-Schurer operators defined by (p,q)-integers (Revised)

, 2015
In the present article, we have given a corrigendum to our paper "Some approximation results on Bernstein-Schurer operators defined by (p,q)-integers" published in Journal of In- equalities and Applications (2015) 2015:249.
Mursaleen, M., Nasiruzzaman, Md., Nurgali, Ashirbayev   +2 more
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Approximation Properties of Chlodovsky-Type Two-Dimensional Bernstein Operators Based on (p, q)-Integers

Symmetry
In the present study, we introduce the two-dimensional Chlodovsky-type Bernstein operators based on the (p,q)-integer. By leveraging the inherent symmetry properties of (p,q)-integers, we examine the approximation properties of our new operator with the help of a Korovkin-type theorem.
Ümit Karabıyık, Ali Karaisa, Adem Ayık   +2 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source