Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The Role of Phosphorus Sources and Phytase in Growth Performance and Feed Digestibility in Broilers
AnimalsPhosphorus (P) is an essential mineral in poultry nutrition, but its low bioavailability from conventional feed ingredients presents a significant challenge for efficient utilization.
Edouard Coudert +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Experimental demonstration of the antiherbivore effects of silica in grasses: impacts on foliage digestibility and vole growth rates [PDF]
, 2006 The impact of plant-based factors on the population dynamics of mammalian herbivores has been the subject of much debate in ecology, but the role of antiherbivore defences in grasses has received relatively little attention.
Hartley, Susan, Massey, F. P.
core +5 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The effect of dietary calcium and other nutritionally relevant divalent cations on fatty acid-soap formation : a dissertation presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Nutritional Sciences at Massey University, Manawatū, New Zealand [PDF]
, 2016 A growing amount of scientific evidence appears to support a relationship between dietary calcium (Ca) and body weight where increased dietary Ca intake leads to weight reduction and the faecal excretion of several fatty acids.
Stroebinger, Natascha
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Nutrient digestibility, growth performance, caecal microbial profile and fermentation characteristics of rabbit bucks fed Piliostigma thonningii essential oil supplemented diet [PDF]
Biotechnology in Animal HusbandryThe purpose of this current experimental research (study) was to examine the effects of Piliostigma thonningii essential oil on the nutrient digestibility, growth characteristics, caecal microbes and fermentation characteristics of rabbits.
Anaso Emmanuel Ugochukwu +3 more
doaj +1 more source
Quantification of nutrient supply in forage-based diets for beef cattle [PDF]
, 2009 End of Project ReportIntroduction Cattle rearing systems in Ireland are predominantly grass-based as 80% of agricultural land is dedicated to grassland (silage, hay and pasture) (CSO, 2007).
McGee, Mark +2 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source