Results 31 to 40 of about 25,979 (261)

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

P. Gingivalils Induces Endothelial Dysfunction By mPTP Via Mitochondrial Fission

International Dental Journal
Aim or purpose: To explore the important role of Drp1-VDAC1-HK2 axis in regulating mitochondrial permeability transition pore (mPTP) opening in Porphyromonas gingivalis (P. gingivalis)-induced endothelial dysfunction.
Yi Wang, Shengming Xu, Hanxin Que
doaj   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Porphyromonas gingivalis outer membrane vesicles augments proliferation and metastasis of oral squamous cell carcinoma cells

BMC Oral Health
Background Porphyromonas gingivalis (P. gingivalis) is closely related to Oral squamous cell carcinoma (OSCC), and P. gingivalis outer membrane vesicles (OMVs) is the main pathogenic factor, which is associated with periodontitis, atherosclerosis and ...
Yanru Zeng, Yiyang Wang, Xiaona Shi, Yuanhao Zhao, Yue Tang, Shanshan Liu, Xiaofeng Zhu   +6 more
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Porphyromonas Gingivalis Survives In BMECs By Kgp Inhibiting Lysosomal Acidification

International Dental Journal
Aim or purpose: This study aimed to investigate Porphyromonas gingivalis (P. gingivalis) persistence in human brain microvascular endothelial cells (BMECs), its impact on cellular lysosomal acidification and regulatory mechanisms, given that brain ...
Angu Li, Xiaolin Tang
doaj   +1 more source

Functional Advantages of Porphyromonas gingivalis Vesicles. [PDF]

PLoS ONE, 2015
Porphyromonas gingivalis is a keystone pathogen of periodontitis. Outer membrane vesicles (OMVs) have been considered as both offense and defense components of this bacterium. Previous studies indicated that like their originating cells, P.
Meng-Hsuan Ho, Chin-Ho Chen, J Shawn Goodwin, Bing-Yan Wang, Hua Xie   +4 more
doaj   +1 more source

P. gingivalis Modulates Keratinocytes through FOXO Transcription Factors

PLoS ONE, 2013
P. gingivalis is a prominent periodontal pathogen that has potent effects on host cells. In this study we challenged gingival epithelial cells with P. gingivalis with the aim of assessing how mRNA levels of key target genes were modulated by P. gingivalis via the transcription factors FOXO1 and FOXO3.
Li, Shuai, Dong, Guangyu, Moschidis, Anastasios, Ortiz, Javier, Kinane, Denis F, Benakanakere, Manjunatha R, Graves, Dana T   +6 more
openaire   +5 more sources

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

ASSOCIATION OF PORPHYROMONUS GINGIVALIS WITH RHEUMATOID ARTHRITIS

The Iraqi Journal of Medical Sciences, 2017
Background:Rheumatoid arthritis (RA) is chronic systemic inflammatory disease. Porphyromonus gingivalis (P. gingivalis) produce peptidyle arginine enzymes, which lead to citrullination of human protein then lead to formation anticitrullinated peptide ...
Sadeq k. Hachim, Ahmed A. Abbas, Mohammed H. Alosami   +2 more
doaj   +6 more sources