Results 11 to 20 of about 25,979 (261)

Magnesium Enhances Immune Clearance of P. gingivalis in Macrophages by Suppressing MCU-Mediated Mitochondrial Calcium Overload. [PDF]

Cell Prolif
Magnesium restores macrophage clearance of P. gingivalis by inhibiting MCU‐mediated calcium overload. P. gingivalis is mainly phagocytosed by macrophages but escapes intracellular clearance via MCU‐mediated mitochondrial and cytosolic Ca2+ overload in periodontitis. The persistent P.
Deng DK, Su MJ, Zhang MY, Tan YJ, Kongling W, Wang HY, Xu M, Liu SY, He XT, Chen FM, Tian BM, Li X.   +11 more
europepmc   +2 more sources

Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis [PDF]

International Immunopharmacology, 2009
Antibody titers to P. gingivalis are increased in patients with rheumatoid arthritis and are associated with disease-specific autoimmunity.Periodontitis (PD) has been implicated as a risk factor for rheumatoid arthritis (RA). We sought to characterize antibody titers to P.
Ted R, Mikuls, Jeffrey B, Payne, Richard A, Reinhardt, Geoffrey M, Thiele, Eileen, Maziarz, Amy C, Cannella, V Michael, Holers, Kristine A, Kuhn, James R, O'Dell   +8 more
openaire   +2 more sources

Localization of P. gingivalis in Preterm Delivery Placenta [PDF]

Journal of Dental Research, 2009
Increasing evidence suggests an association between periodontal disease and adverse pregnancy outcomes. Although infection is considered as a risk factor for preterm delivery, the localization of oral bacteria or their antigens in chorioamnionitis placental tissue has never been demonstrated.
J, Katz, N, Chegini, K T, Shiverick, R J, Lamont   +3 more
openaire   +2 more sources

The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis [PDF]

Journal of Dental Research, 2020
Rheumatoid arthritis (RA), a chronic inflammatory disease affecting primarily the joints, is frequently characterized by the presence of autoimmune anticitrullinated protein antibodies (ACPA) during preclinical stages of disease and accumulation of hypercitrullinated proteins in arthritic joints.
Muñoz-Atienza, E., Flak, M.B., Sirr, J., Paramonov, N.A., Aduse-Opoku, J., Pitzalis, C., Curtis, M.A.   +6 more
openaire   +2 more sources

Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated with Porphyromonas gingivalis [PDF]

PeerJ, 2022
Background Periodontal disease is considered one of the most prevalent chronic infectious diseases, often leading to the disruption of tooth-supporting tissues, including alveolar bone, causing tooth mobility and loss.
Blanca Esther Blancas-Luciano, Ingeborg Becker-Fauser, Jaime Zamora-Chimal, José Delgado-Domínguez, Adriana Ruíz-Remigio, Elba Rosa Leyva-Huerta, Javier Portilla-Robertson, Ana María Fernández-Presas   +7 more
doaj   +2 more sources

Platelet aggregation promoted by biofilms of oral bacteria and the effect of mouth rinses in vitro

Journal of Infection in Developing Countries, 2016
Introduction: The purpose of this study was to observe platelet aggregation promoted by biofilms of Streptococcus sanguinis and Porphyromonas gingivalis and to evaluate the effect of two different mouth rinses on this process.
Yan Tu, Yadong Chen, Chongyang Zheng, Hui Chen   +3 more
doaj   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase

International Journal of Oral Science, 2021
Ulcerative Colitis (UC) has been reported to be related to Porphyromonas gingivalis (P. gingivalis). Porphyromonas gingivalis peptidylarginine deiminase (PPAD), a virulence factor released by P. gingivalis, is known to induce inflammatory responses.
Xida Zhao, Jingbo Liu, Chong Zhang, Ning Yu, Ze Lu, Shuwei Zhang, Yuchao Li, Qian Li, Junchao Liu, Dongjuan Liu, Yaping Pan   +10 more
doaj   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Lipopolysaccharide Preparation Derived From Porphyromonas gingivalis Induces a Weaker Immuno-Inflammatory Response in BV-2 Microglial Cells Than Escherichia coli by Differentially Activating TLR2/4-Mediated NF-κB/STAT3 Signaling Pathways

Frontiers in Cellular and Infection Microbiology, 2021
Alzheimer’s disease (AD) is a degenerative disease of the central nervous system with unclear etiology and pathogenesis. In recent years, as the infectious theory and endotoxin hypothesis of AD has gained substantial attention, several studies have ...
Che Qiu, Che Qiu, Zhen Yuan, Zhiyan He, Zhiyan He, Huiwen Chen, Huiwen Chen, Yue Liao, Yue Liao, Shiliang Li, Wei Zhou, Wei Zhou, Zhongchen Song, Zhongchen Song   +13 more
doaj   +1 more source