Results 121 to 130 of about 18,483,123 (229)

Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling [PDF]

Proceedings of the National Academy of Sciences, 2000
Arabidopsis RPP5 is a member of a large class of pathogen resistance genes encoding nucleotide-binding sites and leucine-rich repeat domains. Yeast two-hybrid analysis showed that RPP5 specifically interacts with At-RSH1, an Arabidopsis RelA/SpoT homolog.
van der Biezen, Erik A., Sun, Jongho, Coleman, Mark J., Bibb, Mervyn J., Jones, Jonathan D. G.   +4 more
openaire   +3 more sources

Condition‐dependent resource allocation strategy governed by CodY regulator in Bacillus subtilis

mLife, Volume 4, Issue 5, Page 539-550, October 2025.
Abstract To thrive in nature, bacteria have to rapidly proliferate in favorable conditions while constantly adapt to the fluctuating nutrient environments. However, the molecular players that ensure rapid growth of bacteria in favorable conditions remain poorly understood.
Haoyan Mu, Yiheng Wang, Yongfu Pei, Xin Wang, Xiongfeng Dai, Manlu Zhu   +5 more
wiley   +1 more source

Small Alarmone Synthetase SasA Expression Leads to Concomitant Accumulation of pGpp, ppApp, and AppppA in Bacillus subtilis

Frontiers in Microbiology, 2020
(p)ppGpp is a highly conserved bacterial alarmone which regulates many aspects of cellular physiology and metabolism. In Gram-positive bacteria such as B.
Danny K. Fung, Jin Yang, David M. Stevenson, Daniel Amador-Noguez, Jue D. Wang   +4 more
doaj   +1 more source

Expression of a small (p)ppGpp synthetase, YwaC, in the (p)ppGpp⁰ mutant of Bacillus subtilis triggers YvyD‐dependent dimerization of ribosome [PDF]

MicrobiologyOpen, 2012
AbstractTo elucidate the biological functions of small (p)ppGpp synthetases YjbM and YwaC of Bacillus subtilis, we constructed RIK1059 and RIK1066 strains carrying isopropyl‐β‐D‐thiogalactopyranoside (IPTG) inducible yjbM and ywaC genes, respectively, in the ΔrelA ΔyjbM ΔywaC triple mutant background.
Tagami, Kazumi, Nanamiya, Hideaki, Kazo, Yuka, Maehashi, Marie, Suzuki, Shota, Namba, Eri, Hoshiya, Masahiro, Hanai, Ryo, Tozawa, Yuzuru, Morimoto, Takuya, Ogasawara, Naotake, Kageyama, Yasushi, Ara, Katsutoshi, Ozaki, Katsuya, Yoshida, Masaki, Kuroiwa, Haruko, Kuroiwa, Tsuneyoshi, Ohashi, Yoshiaki, Kawamura, Fujio   +18 more
openaire   +2 more sources

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, Volume 122, Issue 9, Page 2456-2464, September 2025.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

(p)ppGpp and CodY Promote Enterococcus faecalis Virulence in a Murine Model of Catheter-Associated Urinary Tract Infection

mSphere, 2019
In Firmicutes, the nutrient-sensing regulators (p)ppGpp, the effector molecule of the stringent response, and CodY work in tandem to maintain bacterial fitness during infection. Here, we tested (p)ppGpp and codY mutant strains of Enterococcus faecalis in
C. Colomer-Winter, A. L. Flores-Mireles, S. Kundra, S. J. Hultgren, J. A. Lemos   +4 more
doaj   +1 more source

Gene Transfer Agent Promotes Evolvability within the Fittest Subpopulation of a Bacterial Pathogen [PDF]

, 2017
The Bartonella gene transfer agent (BaGTA) is an archetypical example for domestication of a phage-derived element to permit high-frequency genetic exchange in bacterial populations.
Christen, Beat, Christen, Matthias, Dehio, Christoph, Harms, Alexander, Körner, Jonas, Québatte, Maxime   +5 more
core   +1 more source

Arctic Soil C and N Cycling Are Linked With Microbial Adaptations During Drought

Global Change Biology, Volume 31, Issue 9, September 2025.
To understand responses of Arctic microbial carbon and nitrogen cycling to climate change, we simulated a drought event in a laboratory experiment and tracked microbial gene expression and greenhouse gas emissions across increasing levels of drought.
Theis Thomsen, Morten Dencker Schostag, Anders Priemé, Jonathan Donhauser   +3 more
wiley   +1 more source

Regulation of (p)ppGpp and Its Homologs on Environmental Adaptation, Survival, and Pathogenicity of Streptococci

Frontiers in Microbiology, 2020
Most streptococci are commensals, pathogens, or opportunistic pathogens for humans and animals. Therefore, it is important for streptococci to adapt to the various challenging environments of the host during the processes of infection or colonization, as
Tengfei Zhang, Tengfei Zhang, Jiawen Zhu, Jiawen Zhu, Jiajia Xu, Huabin Shao, Rui Zhou, Rui Zhou, Rui Zhou   +8 more
doaj   +1 more source

Elucidating the role of (p)ppGpp in mycobacterial persistence against antibiotics [PDF]

IUBMB Life, 2018
AbstractBacterial persistence, the ability of bacteria to survive high concentrations of antibiotics for extended periods of time, is an important contributing factor to therapy failure and development of chronic and recurrent infections. Several recent studies have suggested that this persistence is mediated primarily by (p)ppGpp, through its ...
Ashima Bhaskar, Cyntia De Piano, Ekaterina Gelman, John D. McKinney, Neeraj Dhar   +4 more
openaire   +2 more sources