Results 111 to 120 of about 8,365 (192)

Direct detection of stringent alarmones (pp)pGpp using malachite green

Microbial Cell
The alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on developing new drugs
Muriel Schicketanz, Magdalena Petrová, Dominik Rejman, Margherita Sosio, Stefano Donadio, Yong Everett Zhang   +5 more
doaj   +1 more source

Biochemical studies on Francisella tularensis RelA in (p)ppGpp biosynthesis [PDF]

, 2015
The bacterial stringent response is induced by nutrient deprivation and is mediated by enzymes of the RSH (RelA/SpoT homologue; RelA, (p)ppGpp synthetase I; SpoT, (p)ppGpp synthetase II) superfamily that control concentrations of the 'alarmones' (p)ppGpp
Petra C F Oyston, Batten, Laura E., Oyston, Petra C.F., Rachael C Wilkinson, Laura E Batten, Wilkinson, Rachael C., Neil J Wells, Roach, Peter L., Wells, Neil J., Peter L Roach   +9 more
core   +1 more source

Важность (p) ppGpp как регулятора выживания бактерий обусловила необходимость создания антибиотика Relacin, который является негидролизуемым аналогом ppGpp и ингибирует его биосинтез (по [Wexselblatt, 2012; Seal, 2017])

, 2021
Важность (p) ppGpp как регулятора выживания бактерий обусловила необходимость создания антибиотика Relacin, который является негидролизуемым аналогом ppGpp и ингибирует его биосинтез (по [Wexselblatt, 2012; Seal, 2017]
Андрюков БГ
core   +1 more source

Association of Metal Homeostasis and (p)ppGpp Regulation in the Pathophysiology of Enterococcus faecalis.

, 2019
In Enterococcus faecalis, the regulatory nucleotides pppGpp and ppGpp, collectively, (p)ppGpp, are required for growth in blood, survival within macrophages, and virulence. However, a clear understanding of how (p)ppGpp promotes virulence in E.
José A. Lemos (239435), Cristina Colomer-Winter (697911), Anthony O. Gaca (417760)   +2 more
core   +1 more source

MS RHII-RSD, a dual-function RNase HII-(p)ppGpp synthetase fromMycobacterium smegmatis

, 2012
In the noninfectious soil saprophyte Mycobacterium smegmatis, intracellular levels of the stress alarmones guanosine tetraphos-phate and guanosine pentaphosphate, together termed (p)ppGpp, are regulated by the enzyme RelMsm.
Maya S. Murdeshwar, Dipankar Chatterji, Chatterji, Dipankar, Murdeshwar, Maya S, Murdeshwar, Maya S.   +4 more
core   +1 more source

Stringent Response and AggR-Dependent Virulence Regulation in the Enteroaggregative Escherichia coli Strain 042

Frontiers in Microbiology, 2018
Virulence expression in the enteroaggregative Escherichia coli strain 042 requires the transcriptional activator AggR. We show in this report that, as reported for other virulence factors, the nucleotide second messenger (p)ppGpp is needed for a high ...
Mário Hüttener, Alejandro Prieto, Joan Espelt, Manuel Bernabeu, Antonio Juárez, Antonio Juárez   +5 more
doaj   +1 more source

Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling

, 2000
Arabidopsis RPP5 is a member of a large class of pathogen resistance genes encoding nucleotide-binding sites and leucine-rich repeat domains. Yeast two-hybrid analysis showed that RPP5 specifically interacts with At-RSH1, an Arabidopsis RelA/SpoT homolog.
Bibb, Mervyn J., Jones, Jonathan D. G., van der Biezen, Erik A., Sun, Jongho, Coleman, Mark J.   +4 more
core   +1 more source

Within and beyond the stringent response-RSH and (p)ppGpp in plants [PDF]

, 2017
Plant RSH proteins are able to synthetize and/or hydrolyze unusual nucleotides called (p)ppGpp or alarmones. These molecules regulate nuclear and chloroplast transcription, chloroplast translation and plant development and stress response.
Boniecka, Justyna, Justyna Boniecka, Goc, Anna, Grażyna B. Dąbrowska, Dąbrowska, Grażyna B., Justyna Prusińska, Prusińska, Justyna, Anna Goc   +7 more
core   +1 more source

Contributions of SpoT Hydrolase, SpoT Synthetase, and RelA Synthetase to Carbon Source Diauxic Growth Transitions in Escherichia coli

Frontiers in Microbiology, 2018
During the diauxic shift, Escherichia coli exhausts glucose and adjusts its expression pattern to grow on a secondary carbon source. Transcriptional profiling studies of glucose–lactose diauxic transitions reveal a key role for ppGpp. The amount of ppGpp
Llorenç Fernández-Coll, Michael Cashel
doaj   +1 more source

Relative intracellular ppGpp level of ppGpp biosynthesis gene mutants andcomplementation strains.

, 2019
Relative intracellular ppGpp level of ppGpp biosynthesis gene mutants andcomplementation strains.
Lindsay R. Triplett (3156762), Xiaochen Yuan (3569585), Jie Wang (16762), Quan Zeng (228353), Zhouqi Cui (5462006), George W. Sundin (7252556), Ching-Hong Yang (2027971), Roshni R. Kharadi (7134932)   +7 more
core   +1 more source