Results 91 to 100 of about 8,365 (192)

Small Alarmone Synthetase SasA Expression Leads to Concomitant Accumulation of pGpp, ppApp, and AppppA in Bacillus subtilis

Frontiers in Microbiology, 2020
(p)ppGpp is a highly conserved bacterial alarmone which regulates many aspects of cellular physiology and metabolism. In Gram-positive bacteria such as B.
Danny K. Fung, Jin Yang, David M. Stevenson, Daniel Amador-Noguez, Jue D. Wang   +4 more
doaj   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, Volume 5, Issue 2, Page 180-198, April 2026.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption

mSphere, 2020
Bacteria grow in constantly changing environments that can suddenly become completely depleted of essential nutrients. The stringent response, a rewiring of the cellular metabolism mediated by the alarmone (p)ppGpp, plays a crucial role in adjusting ...
Clément Patacq, Nicolas Chaudet, Fabien Létisse   +2 more
doaj   +1 more source

Ribosome State Distributions Define Escherichia coli Persister Physiology: Links to Formation, Stress Responses, and Resuscitation Dynamics

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The AUCS70/AUCS100 ratio, derived from ribosome sedimentation profiling, quantitatively distinguishes Escherichia coli persisters from growing cells across multiple stress conditions and identifies RMF as the primary target for anti‐persistence strategies. ABSTRACT Persister cells survive antibiotic exposure and contribute to infection relapse, yet the
Hyein Kim, Sooyeon Song
wiley   +1 more source

Assessment of airway distribution of transnasal solutions in mice by PET/CT imaging. [PDF]

, 2009
PURPOSE: Transnasal administration is one of the most common routes for allergen challenge in mouse models of airway diseases. Although this technique is widely used, neither the amount of allergen that reaches the lung nor its airway distribution has ...
Zubeldia, José Manuel, Desco, M., M Desco, Baeza, ML, JJ Vaquero, Soto-Montenegro, M. L., Zubeldia Ortuño, José Manuel, JM Zubeldia, Conejero, L., Vaquero, JJ, Soto Montenegro, M. L., Baeza, M. L., L Conejero, Vaquero, J.J., Conejero, L, Soto Montenegro, Mª Luisa, Soto Montenegro, M.L., Desco Menéndez, Manuel, Desco, Manuel, Conejero, Laura, Vaquero López, Juan José, Soto-Montenegro, ML, ML Baeza, Desco, M, Vaquero, Juan José, Baeza, M.L., Zubeldia, JM, ML Soto-Montenegro   +27 more
core   +1 more source

Regulation of (p)ppGpp and Its Homologs on Environmental Adaptation, Survival, and Pathogenicity of Streptococci

Frontiers in Microbiology, 2020
Most streptococci are commensals, pathogens, or opportunistic pathogens for humans and animals. Therefore, it is important for streptococci to adapt to the various challenging environments of the host during the processes of infection or colonization, as
Tengfei Zhang, Tengfei Zhang, Jiawen Zhu, Jiawen Zhu, Jiajia Xu, Huabin Shao, Rui Zhou, Rui Zhou, Rui Zhou   +8 more
doaj   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

(p)ppGpp and CodY Promote Enterococcus faecalis Virulence in a Murine Model of Catheter-Associated Urinary Tract Infection

mSphere, 2019
In Firmicutes, the nutrient-sensing regulators (p)ppGpp, the effector molecule of the stringent response, and CodY work in tandem to maintain bacterial fitness during infection. Here, we tested (p)ppGpp and codY mutant strains of Enterococcus faecalis in
C. Colomer-Winter, A. L. Flores-Mireles, S. Kundra, S. J. Hultgren, J. A. Lemos   +4 more
doaj   +1 more source

Studies on the Regulation of (p)ppGpp Metabolism and Its Perturbation Through the Over-Expression of Nudix Hydrolases in Escherichia coli

Frontiers in Microbiology, 2020
Stringent response mediated by modified guanosine nucleotides is conserved across bacteria and is regulated through the Rel/Spo functions. In Escherichia coli, RelA and SpoT proteins synthesize the modified nucleotides ppGpp and pppGpp, together referred
Rajeshree Sanyal, Allada Vimala, Rajendran Harinarayanan   +2 more
doaj   +1 more source

Exploring Multifunctional Microbial Genes From the Rhizosphere of Allium ampeloprasum Under Different Fertilization Systems

Environmental DNA, Volume 8, Issue 2, March/April 2026.
This study uncovers key multifunctional genes in the rhizosphere of Allium ampeloprasum under varying fertilization systems. This highlights their roles in nutrient cycling, plant growth promotion, and soil health, thereby offering insight for sustainable agricultural sustainability.
Oluwaseun Emmanuel Shittu, Ben Jesuorsemwen Enagbonma, Olubukola Oluranti Babalola   +2 more
wiley   +1 more source