Results 1 to 10 of about 7,972 (181)

Diversity in E. coli (p)ppGpp Levels and Its Consequences

Frontiers in Microbiology, 2020
(p)ppGpp is at the core of global bacterial regulation as it controls growth, the most important aspect of life. It would therefore be expected that at least across a species the intrinsic (basal) levels of (p)ppGpp would be reasonably constant.
Beny Spira, Katia Ospino
doaj   +1 more source

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

eLife, 2019
The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its ...
Brent W Anderson, Kuanqing Liu, Christine Wolak, Katarzyna Dubiel, Fukang She, Kenneth A Satyshur, James L Keck, Jue D Wang   +7 more
doaj   +1 more source

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

PLoS Pathogens, 2021
Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p ...
N Y Elizabeth Chau, Shehryar Ahmad, John C Whitney, Brian K Coombes   +3 more
doaj   +1 more source

The Role of RelA and SpoT on ppGpp Production, Stress Response, Growth Regulation, and Pathogenicity in Xanthomonas campestris pv. campestris

Microbiology Spectrum, 2021
The alarmone ppGpp plays an important role in the survival of bacteria by triggering the stringent response when exposed to environmental stress. Although Xanthomonas campestris pv.
Kaihong Bai, Huayu Yan, Xing Chen, Qingyang Lyu, Na Jiang, Jianqiang Li, Laixin Luo   +6 more
doaj   +1 more source

SlyA Transcriptional Regulator Is Not Directly Affected by ppGpp Levels

Frontiers in Microbiology, 2020
The SlyA transcriptional regulator controls the expression of genes involved in virulence and production of surface components in S. Typhimurium and E. coli.
Julia Bartoli, Julie Pamela Viala, Emmanuelle Bouveret   +2 more
doaj   +1 more source

Possible Roles for Basal Levels of (p)ppGpp: Growth Efficiency Vs. Surviving Stress

Frontiers in Microbiology, 2020
Two (p)ppGpp nucleotide analogs, sometimes abbreviated simply as ppGpp, are widespread in bacteria and plants. Their name alarmone reflects a view of their function as intracellular hormone-like protective alarms that can increase a 100-fold when sensing
Llorenç Fernández-Coll, Michael Cashel
doaj   +1 more source

Regulation of ytfK by cAMP-CRP Contributes to SpoT-Dependent Accumulation of (p)ppGpp in Response to Carbon Starvation YtfK Responds to Glucose Exhaustion

Frontiers in Microbiology, 2021
Guanosine penta- or tetraphosphate (known as (p)ppGpp) serves as second messenger to respond to nutrient downshift and other environmental stresses, a phenomenon called stringent response.
Laura Meyer, Elsa Germain, Etienne Maisonneuve   +2 more
doaj   +1 more source

Direct detection of stringent alarmones (pp)pGpp using malachite green

Microbial Cell
The alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on developing new drugs
Muriel Schicketanz, Magdalena Petrová, Dominik Rejman, Margherita Sosio, Stefano Donadio, Yong Everett Zhang   +5 more
doaj   +1 more source

Acabou o rolê?

Revista Espaço Acadêmico, 2023
Diante das inúmeras consequências impostas pelo contágio da Covid-19 as sociedades precisaram readaptar os vários processos de vivências e experiências cotidianas presentes.
Paulo de Tarso Xavier Sousa Junior, Elaine Ferreira do Nascimento   +1 more
doaj  

The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC

mBio, 2019
The stringent response enables bacteria to respond to a variety of environmental stresses, especially various forms of nutrient limitation. During the stringent response, the cell produces large quantities of the nucleotide alarmone ppGpp, which ...
James A. Kraemer, Allen G. Sanderlin, Michael T. Laub   +2 more
doaj   +1 more source