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ppGpp: magic beyond RNA polymerase
Nature Reviews Microbiology, 2012During stress, bacteria undergo extensive physiological transformations, many of which are coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by redirecting the RNA polymerase (RNAP) to certain genes, it also acts as a signal in many other cellular processes in bacteria. After a brief overview of ppGpp biosynthesis and
Zachary D Dalebroux +2 more
exaly +3 more sources
Journal of Molecular Biology, 2001
To determine the role of ppGpp in both negative and positive regulation of transcription initiation during exponential growth in Escherichia coli, we examined transcription in vivo and in vitro from the growth-rate-dependent rRNA promoter rrnB P1 and from the inversely growth-rate-dependent amino acid biosynthesis/transport promoters PargI, PhisG ...
Tamás Gaal, Richard L Gourse
exaly +3 more sources
To determine the role of ppGpp in both negative and positive regulation of transcription initiation during exponential growth in Escherichia coli, we examined transcription in vivo and in vitro from the growth-rate-dependent rRNA promoter rrnB P1 and from the inversely growth-rate-dependent amino acid biosynthesis/transport promoters PargI, PhisG ...
Tamás Gaal, Richard L Gourse
exaly +3 more sources
(p)ppGpp and the Stringent Response: An Emerging Threat to Antibiotic Therapy
ACS Infectious Diseases, 2019In 1969, Cashel and Gallant first observed the presence of (p)ppGpp - the signalling molecule of the stringent response - in starved bacterial cells. Fifty years later, (p)ppGpp and the stringent response have emerged as essential master regulators of ...
Joanne K Hobbs, Alisdair B Boraston
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Plant and Cell Physiology, 2022
Guanosine-tetraphosphate (ppGpp) is known as an alarmone that mediates bacterial stress responses. In plants, ppGpp is synthesized in chloroplasts from GTP and ATP and functions as a regulator of chloroplast gene expression to affect photosynthesis and ...
Kazuhiro Ito +6 more
semanticscholar +1 more source
Guanosine-tetraphosphate (ppGpp) is known as an alarmone that mediates bacterial stress responses. In plants, ppGpp is synthesized in chloroplasts from GTP and ATP and functions as a regulator of chloroplast gene expression to affect photosynthesis and ...
Kazuhiro Ito +6 more
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
Abstract The chemical synthesis of ppGpp (guanosine 3′,5′-dipyrophosphate) is described. The synthesis started from guanosine 3′,5′-diphosphate. The acidlabile ethoxyethyl group was used to protect the 2′-OH functional group. The pyrophosphate linkages were built up simultaneously according to the anionexchange method and the protecting group was ...
A, Simoncsits, J, Tomasz
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Abstract The chemical synthesis of ppGpp (guanosine 3′,5′-dipyrophosphate) is described. The synthesis started from guanosine 3′,5′-diphosphate. The acidlabile ethoxyethyl group was used to protect the 2′-OH functional group. The pyrophosphate linkages were built up simultaneously according to the anionexchange method and the protecting group was ...
A, Simoncsits, J, Tomasz
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Regulation of nitrogen starvation responses by the alarmone (p)ppGpp in rice.
Journal of genetics and genomics = Yi chuan xue bao, 2022Nitrogen is an essential macronutrient for all living organisms and is critical for crop productivity and quality. In higher plants, inorganic nitrogen is absorbed through roots and then assimilates into amino acids by the highly conserved glutamine ...
Hanwen Li +18 more
semanticscholar +1 more source
Glyphosate induces the synthesis of ppGpp
Molecular Genetics and Genomics, 2018Glyphosate, the most widely used herbicide in both agricultural and urban areas is toxic for plants and for many bacterial species. The mechanism of action of glyphosate is through the inhibition of the EPSP synthase, a key enzyme in the biosynthetic pathway of aromatic amino acids.
Gabriela Torres Cruvinel +2 more
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ppGpp cycle in Escherichia coli
Molecular and General Genetics MGG, 1977Kinetics of accumulation and degradation of ppGpp and pppGpp were analysed in spoT+ and spoT strains of Escherichia coli. The experimental data in this paper indicate that on degradation ppGpp is not converted to pppGpp but instead is converted to GDP which is in turn phosphorylated to GTP.
C, Kari, I, Török, A, Travers
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Stringency without ppGpp accumulation
Nature, 1981Wild-type Escherichia coli deprived of a required amino acid shows a stringent response involving various alterations in the cell's normal physiology, including the arrest of net synthesis of stable (ribosomal and transfer) RNA, lipids, phospholipids and peptidoglycans1.
A, Spadaro +3 more
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Journal of Cellular Physiology, 2010
AbstractIn recent years, emerging and reemerging pathogens resistant to nearly all available antibiotics are on the rise. This limits the availability of effective antibiotics to treat infections, thus it is imperative to develop new drugs. The accumulation of alarmones guanosine tetraphosphate and guanosine pentaphosphate, collectively known as (p ...
Jun, Wu, Quanxin, Long, Jianping, Xie
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AbstractIn recent years, emerging and reemerging pathogens resistant to nearly all available antibiotics are on the rise. This limits the availability of effective antibiotics to treat infections, thus it is imperative to develop new drugs. The accumulation of alarmones guanosine tetraphosphate and guanosine pentaphosphate, collectively known as (p ...
Jun, Wu, Quanxin, Long, Jianping, Xie
openaire +2 more sources