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ppGpp signaling plays a critical role in virulence of Acinetobacter baumannii
Virulence, 2021 Acinetobacter baumannii, a major nosocomial pathogen, survives in diverse hospital environments, and its multidrug resistance is a major concern. The ppGpp-dependent stringent response mediates the reprogramming of genes with diverse functions in several
Kyeongmin Kim +8 more
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(p)ppGpp: Still Magical? [PDF]
Annual Review of Microbiology, 2008 The fundamental details of how nutritional stress leads to elevating (p)ppGpp are questionable. By common usage, the meaning of the stringent response has evolved from the specific response to (p)ppGpp provoked by amino acid starvation to all responses caused by elevating (p)ppGpp by any means.
Potrykus, Katarzyna, Cashel, Michael
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ppGpp is a bacterial cell size regulator [PDF]
Current Biology, 2020 Summary Growth and division are central to cell size. Bacteria achieve size homeostasis by dividing when growth has added a constant size since birth, termed the “adder” principle, by unknown mechanisms [1–4]. Growth is well known to be regulated by ppGpp, which controls anything from ribosome production to metabolic enzyme activity and
Ferhat Büke +4 more
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ppGpp analogues as antibacterial compounds [PDF]
Nucleic Acids Symposium Series, 2008 Immediately after sensing the inception of amino acid starvation, bacteria respond pleiotropically with the stringent response via RelA, mainly resulting in the accumulation of the signal molecule (p)ppGpp. A series of analogues of ppGpp that inhibit RelA activity was prepared in order to control the ability of bacteria cells to react to the changes in
Wexselblatt, Ezequiel +3 more
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Frontiers in Microbiology, 2020 (p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha +3 more
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Frontiers in Microbiology, 2020 The molecule guanosine tetraphophosphate (ppGpp) is most commonly considered an alarmone produced during acute stress. However, ppGpp is also present at low concentrations during steady-state growth.
Nicole C. E. Imholz +3 more
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Co-crystalization reveals the interaction between AtYchF1 and ppGpp
Frontiers in Molecular Biosciences, 2022 AtYchF1 is an unconventional G-protein in Arabidopsis thaliana that exhibits relaxed nucleotide-binding specificity. The bindings between AtYchF1 and biomolecules including GTP, ATP, and 26S rRNA have been reported.
Ming-Yan Cheung +4 more
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ppGpp Conjures Bacterial Virulence [PDF]
Microbiology and Molecular Biology Reviews, 2010 SUMMARYLike for all microbes, the goal of every pathogen is to survive and replicate. However, to overcome the formidable defenses of their hosts, pathogens are also endowed with traits commonly associated with virulence, such as surface attachment, cell or tissue invasion, and transmission.
Zachary D, Dalebroux +3 more
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BMC Microbiology, 2011 Background Sigma factors and the alarmone ppGpp control the allocation of RNA polymerase to promoters under stressful conditions. Both ppGpp and the sigma factor σS (RpoS) are potentially subject to variability across the species Escherichia coli.
Phan Katherine +4 more
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(p)ppGpp Metabolism and Antimicrobial Resistance in Bacterial Pathogens
Frontiers in Microbiology, 2020 Single cell microorganisms including pathogens relentlessly face myriads of physicochemical stresses in their living environment. In order to survive and multiply under such unfavorable conditions, microbes have evolved with complex genetic networks ...
Bhabatosh Das, Rupak K. Bhadra
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