Results 21 to 30 of about 4,765 (208)
(p)ppGpp Metabolism and Antimicrobial Resistance in Bacterial Pathogens
Frontiers in Microbiology, 2020 Single cell microorganisms including pathogens relentlessly face myriads of physicochemical stresses in their living environment. In order to survive and multiply under such unfavorable conditions, microbes have evolved with complex genetic networks ...
Bhabatosh Das, Rupak K. Bhadra
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SlyA Transcriptional Regulator Is Not Directly Affected by ppGpp Levels
Frontiers in Microbiology, 2020 The SlyA transcriptional regulator controls the expression of genes involved in virulence and production of surface components in S. Typhimurium and E. coli.
Julia Bartoli +2 more
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Transcriptional Responses to ppGpp and DksA [PDF]
Annual Review of Microbiology, 2018 The stringent response to nutrient deprivation is a stress response found throughout the bacterial domain of life. Although first described in proteobacteria for matching ribosome synthesis to the cell's translation status and for preventing formation of defective ribosomal particles, the response is actually much broader, regulating many hundreds of ...
Richard L, Gourse +5 more
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Frontiers in Microbiology, 2022 The stringent response mediated by the signal molecule (p)ppGpp is involved in response to multiple environmental stresses and control of various physiological processes.
Wen-Liang Yin +29 more
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ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation
Molecular Cell, 2020 Summary (p)ppGpp is a nucleotide messenger universally produced in bacteria following nutrient starvation. In E. coli, ppGpp inhibits purine-nucleotide synthesis by targeting several different enzymes, but the physiological significance of their ...
Boyuan Wang +2 more
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mLife, 2022 Antibiotics combat bacteria through their bacteriostatic (by growth inhibition) or bactericidal (by killing bacteria) action. Mechanistically, it has been proposed that bactericidal antibiotics trigger cellular damage, while bacteriostatic antibiotics ...
Jin Yang +3 more
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Microbiology Spectrum, 2022 Stringent response plays an important role in the response of Enterobacteriaceae pathogens to rapid environmental changes. It has been shown that synergistic and antagonistic actions exist between the signaling molecules (p)ppGpp and DksA in several ...
Can Huang +3 more
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Structural Basis for Transcription Regulation by Alarmone ppGpp [PDF]
Cell, 2004 Guanosine-tetraphosphate (ppGpp) is a major regulator of stringent control, an adaptive response of bacteria to amino acid starvation. The 2.7 A resolution structure of the Thermus thermophilus RNA polymerase (RNAP) holoenzyme in complex with ppGpp reveals that ppGpp binds to the same site near the active center in both independent RNAP molecules in ...
Artsimovitch, Irina +7 more
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Possible Roles for Basal Levels of (p)ppGpp: Growth Efficiency Vs. Surviving Stress
Frontiers in Microbiology, 2020 Two (p)ppGpp nucleotide analogs, sometimes abbreviated simply as ppGpp, are widespread in bacteria and plants. Their name alarmone reflects a view of their function as intracellular hormone-like protective alarms that can increase a 100-fold when sensing
Llorenç Fernández-Coll, Michael Cashel
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Microbiology Spectrum, 2021 The alarmone ppGpp plays an important role in the survival of bacteria by triggering the stringent response when exposed to environmental stress. Although Xanthomonas campestris pv.
Kaihong Bai +6 more
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