Results 41 to 50 of about 7,972 (181)
Microbiota Medicine Research, EarlyView.Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi +7 more
wiley +1 more source
Yeast, EarlyView.ABSTRACT All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free‐living microbes directly exposed to a changing environment.
Audrey P. Gasch
wiley +1 more source
Basal Levels of (p)ppGpp in
mBio, 2013 The stringent response (SR), mediated by the alarmone (p)ppGpp, is a conserved bacterial adaptation system controlling broad metabolic alterations necessary for survival under adverse conditions.
Anthony O. Gaca +6 more
doaj +1 more source
Survival of the Fittest: The Relationship of (p)ppGpp With Bacterial Virulence
Frontiers in Microbiology, 2020 The signaling nucleotide (p)ppGpp has been the subject of intense research in the past two decades. Initially discovered as the effector molecule of the stringent response, a bacterial stress response that reprograms cell physiology during amino acid ...
Shivani Kundra +2 more
doaj +1 more source
Molecular Microbiology, EarlyView.A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo +5 more
wiley +1 more source
Frontiers in Microbiology, 2022 The stringent response mediated by the signal molecule (p)ppGpp is involved in response to multiple environmental stresses and control of various physiological processes.
Wen-Liang Yin +29 more
doaj +1 more source
(p)ppGpp and the bacterial cell cycle
Journal of Biosciences, 2016 Genes of the Rel/Spo homolog (RSH) superfamily synthesize and/or hydrolyse the modified nucleotides pppGpp/ ppGpp (collectively referred to as (p)ppGpp) and are prevalent across diverse bacteria and in plant chloroplasts. Bacteria accumulate (p)ppGpp in response to nutrient deprivation (generically called the stringent response) and elicit appropriate ...
Aanisa, Nazir, Rajendran, Harinarayanan
openaire +2 more sources
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence
MicrobiologyOpen, Volume 15, Issue 4, August 2026.Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi +2 more
wiley +1 more source
Microbiology Spectrum, 2022 Stringent response plays an important role in the response of Enterobacteriaceae pathogens to rapid environmental changes. It has been shown that synergistic and antagonistic actions exist between the signaling molecules (p)ppGpp and DksA in several ...
Can Huang +3 more
doaj +1 more source
Regulation of ς factor competition by the alarmone ppGpp [PDF]
Genes & Development, 2002 Many regulons controlled by alternative ς factors, including ς S and ς 32 , are poorly induced in cells lacking the alarmone ppGpp. We show that ppGpp is not absolutely required for the activity of ς S -dependent ...
Miki, Jishage +3 more
openaire +2 more sources