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Regulatory Themes and Variations by the Stress-Signaling Nucleotide Alarmones (p)ppGpp in Bacteria
Annual Review of Genetics, 2021 Bacterial stress-signaling alarmones are important components of a protective network against diverse stresses such as nutrient starvation and antibiotic assault.
B. Anderson, Danny K. Fung, Jue D. Wang
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Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp
Nature Communications, 2022 The stringent response enables bacteria to respond to nutrient limitation and other stress conditions through production of the nucleotide-based second messengers ppGpp and pppGpp, collectively known as (p)ppGpp.
Laura Czech +12 more
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(p)ppGpp: Still Magical? [PDF]
Annual Review of Microbiology, 2008 The fundamental details of how nutritional stress leads to elevating (p)ppGpp are questionable. By common usage, the meaning of the stringent response has evolved from the specific response to (p)ppGpp provoked by amino acid starvation to all responses caused by elevating (p)ppGpp by any means.
Potrykus, Katarzyna, Cashel, Michael
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Nature Communications, 2021 Many bacteria use cyclic di-AMP as a second messenger to control potassium and osmotic homeostasis. In Bacillus subtilis, several c-di-AMP binding proteins and RNA molecules have been identified. Most of these targets play a role in controlling potassium
Larissa Krüger +8 more
semanticscholar +1 more source
ppGpp analogues as antibacterial compounds [PDF]
Nucleic Acids Symposium Series, 2008 Immediately after sensing the inception of amino acid starvation, bacteria respond pleiotropically with the stringent response via RelA, mainly resulting in the accumulation of the signal molecule (p)ppGpp. A series of analogues of ppGpp that inhibit RelA activity was prepared in order to control the ability of bacteria cells to react to the changes in
Wexselblatt, Ezequiel +3 more
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New Phytologist, 2022 Summary The nucleotides guanosine tetraphosphate and guanosine pentaphosphate (together (p)ppGpp) are found in a wide range of prokaryotic and eukaryotic organisms where they are associated with stress signalling.
Marwa Mehrez, Shanna Romand, B. Field
semanticscholar +1 more source
Co-crystalization reveals the interaction between AtYchF1 and ppGpp
Frontiers in Molecular Biosciences, 2022 AtYchF1 is an unconventional G-protein in Arabidopsis thaliana that exhibits relaxed nucleotide-binding specificity. The bindings between AtYchF1 and biomolecules including GTP, ATP, and 26S rRNA have been reported.
Ming-Yan Cheung +4 more
doaj +1 more source
Nucleic Acids Research, 2021 The nucleotide messenger (p)ppGpp allows bacteria to adapt to fluctuating environments by reprogramming the transcriptome. Despite its well-recognized role in gene regulation, (p)ppGpp is only known to directly affect transcription in Proteobacteria by ...
B. Anderson +9 more
semanticscholar +1 more source
Molecules and Cells, 2021 Amino acid starvation is sensed by Escherichia coli RelA and Bacillus subtilis Rel through monitoring the aminoacylation status of ribosomal A-site tRNA.
Mohammad Roghanian +11 more
semanticscholar +1 more source
Frontiers in Microbiology, 2020 (p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha +3 more
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