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Microbiology Spectrum, 2023 ppGpp is a ubiquitous small nucleotide messenger that mediates cellular self-protective responses under environmental stress. However, the mechanisms of ppGpp that control transcription and other metabolic processes depend on the species, and ppGpp ...
Yang Song +4 more
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ppGpp Conjures Bacterial Virulence [PDF]
Microbiology and Molecular Biology Reviews, 2010 SUMMARYLike for all microbes, the goal of every pathogen is to survive and replicate. However, to overcome the formidable defenses of their hosts, pathogens are also endowed with traits commonly associated with virulence, such as surface attachment, cell or tissue invasion, and transmission.
Zachary D, Dalebroux +3 more
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Transcription regulation of the Escherichia coli pcnB gene coding for poly(A) polymerase I: roles of ppGpp, DksA and sigma factors [PDF]
, 2010 Poly(A) polymerase I (PAP I), encoded by the pcnB gene, is a major enzyme responsible for RNA polyadenylation in Escherichia coli, a process involved in the global control of gene expression in this bacterium through inXuencing the rate of transcript ...
Grzegorz Węgrzyn +11 more
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BMC Microbiology, 2011 Background Sigma factors and the alarmone ppGpp control the allocation of RNA polymerase to promoters under stressful conditions. Both ppGpp and the sigma factor σS (RpoS) are potentially subject to variability across the species Escherichia coli.
Phan Katherine +4 more
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Frontiers in Microbiology, 2020 The molecule guanosine tetraphophosphate (ppGpp) is most commonly considered an alarmone produced during acute stress. However, ppGpp is also present at low concentrations during steady-state growth.
Nicole C. E. Imholz +3 more
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ppGpp functions as an alarmone in metazoa [PDF]
Communications Biology, 2019 Abstract Guanosine 3’,5’-bis(pyrophosphate) (ppGpp) functions as a second messenger in bacteria to adjust their physiology in response to environmental changes. In recent years, the ppGpp-specific hydrolase, metazoan SpoT homolog-1 (Mesh1), was shown to have important roles for growth under nutrient deficiency in
Doshun Ito +9 more
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Role of RelA and SpoT in Burkholderia pseudomallei Virulence and Immunity [PDF]
, 2012 Burkholderia pseudomallei is a Gram-negative soil bacterium and the causative agent of melioidosis, a disease of humans and animals. It is also listed as a category B bioterrorism threat agent by the U.S.
Wand, ME +11 more
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, 2021 The amount of ppGpp was measured relative to total amount of G (pppGpp + ppGpp + GTP) by TLC in MG1655 and ΔrelA strains grown in MOPS media with 0.2% glucose or 0.4% glycerol. Error bars represent SD of two biological replicates.
Chunghwan Ro (11614177) +2 more
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ppGpp influences protein protection, growth and photosynthesis in Phaeodactylum tricornutum [PDF]
, 2020 International audienceChloroplasts retain elements of a bacterial stress response pathway that is mediated by the signalling nucleotides guanosine penta- and tetraphosphate, or (p)ppGpp.
Lebrun, Regine +20 more
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The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly
Cells, 2019 Many facets of ribosome biogenesis and function, including ribosomal RNA (rRNA) transcription, 70S assembly and protein translation, are negatively impacted upon induction of a nutrient stress-sensing signalling pathway termed the stringent response ...
Daniel J. Bennison +2 more
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