Results 71 to 80 of about 7,972 (181)

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, Volume 5, Issue 2, Page 180-198, April 2026.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

Ribosome State Distributions Define Escherichia coli Persister Physiology: Links to Formation, Stress Responses, and Resuscitation Dynamics

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The AUCS70/AUCS100 ratio, derived from ribosome sedimentation profiling, quantitatively distinguishes Escherichia coli persisters from growing cells across multiple stress conditions and identifies RMF as the primary target for anti‐persistence strategies. ABSTRACT Persister cells survive antibiotic exposure and contribute to infection relapse, yet the
Hyein Kim, Sooyeon Song
wiley   +1 more source

Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption

mSphere, 2020
Bacteria grow in constantly changing environments that can suddenly become completely depleted of essential nutrients. The stringent response, a rewiring of the cellular metabolism mediated by the alarmone (p)ppGpp, plays a crucial role in adjusting ...
Clément Patacq, Nicolas Chaudet, Fabien Létisse   +2 more
doaj   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Exploring Multifunctional Microbial Genes From the Rhizosphere of Allium ampeloprasum Under Different Fertilization Systems

Environmental DNA, Volume 8, Issue 2, March/April 2026.
This study uncovers key multifunctional genes in the rhizosphere of Allium ampeloprasum under varying fertilization systems. This highlights their roles in nutrient cycling, plant growth promotion, and soil health, thereby offering insight for sustainable agricultural sustainability.
Oluwaseun Emmanuel Shittu, Ben Jesuorsemwen Enagbonma, Olubukola Oluranti Babalola   +2 more
wiley   +1 more source

How the initiating ribosome copes with ppGpp to translate mRNAs.

PLoS Biology, 2020
During host colonization, bacteria use the alarmones (p)ppGpp to reshape their proteome by acting pleiotropically on DNA, RNA, and protein synthesis. Here, we elucidate how the initiating ribosome senses the cellular pool of guanosine nucleotides and ...
Daria S Vinogradova, Victor Zegarra, Elena Maksimova, Jose Alberto Nakamoto, Pavel Kasatsky, Alena Paleskava, Andrey L Konevega, Pohl Milón   +7 more
doaj   +1 more source

Cidades Rebeldes: apropriação dos espaços públicos e os movimentos sociais urbanos

Conversas & Controvérsias, 2018
RESENHA: David HARVEY. Cidades rebeldes: do direito à cidade à revolução urbana. São Paulo: Martins Fontes, 2014.
Julia Giles Wünsch
doaj  

ppGpp Formation in Escherichia coli Treated with Rifampicin

Journal of Biological Chemistry, 1971
Abstract It has been previously reported that the accumulation of the regulatory nucleotide ppGpp (MS I), which is governed by the RC gene of Escherichia coli, does not occur in the presence of rifampicin. Since this drug inhibits RNA chain initiation, it was suggested that the formation of ppGpp is somehow dependent on the presence of nascent RNA ...
H, Erlich, T, Laffler, J, Gallant
openaire   +2 more sources

Implicações do neoliberalismo na garantia de direitos da pessoa humana em saúde mental: Uma análise a partir do contexto da política pública de saúde mental brasileira

Revista Direitos Humanos e Democracia
O presente artigo tem como tema o direito humano à saúde mental, delimitado no objeto das implicações do neoliberalismo na garantia de direitos da pessoa humana em saúde mental.
Ruan Didier Bruzaca, Claudineide Alves dos Santos   +1 more
doaj   +1 more source

Comparative proteomic analysis of Salmonella enterica serovar Typhimurium ppGpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages

BMC Microbiology, 2010
Background The global ppGpp-mediated stringent response in pathogenic bacteria plays an important role in the pathogenesis of bacterial infections. In Salmonella enterica serovar Typhimurium (S. Typhimurium), several genes, including virulence genes, are
Kumagai Yoshinori, Miki Tsuyoshi, Shimizu-Izumi Satomi, Maeda Tadakazu, Oh-Ishi Masamichi, Kodera Yoshio, Yoshida-Ohta Yukie, Sugimoto Mariko, Haneda Takeshi, Danbara Hirofumi, Okada Nobuhiko   +10 more
doaj   +1 more source