Results 71 to 80 of about 4,765 (208)

Dual role of a (p)ppGpp‐ and (p)ppApp‐degrading enzyme in biofilm formation and interbacterial antagonism

Molecular Microbiology, 2021
The guanosine nucleotide‐based second messengers ppGpp and pppGpp (collectively: (p)ppGpp) enable adaptation of microorganisms to environmental changes and stress conditions. In contrast, the closely related adenosine nucleotides (p)ppApp are involved in
Wieland Steinchen, Shehryar Ahmad, Martina Valentini, Kira Eilers, Mohamad Majkini, F. Altegoer, Marcus Lechner, A. Filloux, J. Whitney, G. Bange   +9 more
semanticscholar   +1 more source

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

eLife, 2019
The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its ...
Brent W Anderson, Kuanqing Liu, Christine Wolak, Katarzyna Dubiel, Fukang She, Kenneth A Satyshur, James L Keck, Jue D Wang   +7 more
doaj   +1 more source

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

PLoS Pathogens, 2021
Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p ...
N Y Elizabeth Chau, Shehryar Ahmad, John C Whitney, Brian K Coombes   +3 more
doaj   +1 more source

Diverse molecular mechanisms of transcription regulation by the bacterial alarmone ppGpp

Molecular Microbiology, 2021
Bacteria must rapidly detect and respond to stressful environmental conditions. Guanosine tetraphosphate (ppGpp) is a universal stress signal that, in most bacteria, drives the reprograming of transcription at a global level. However, recent studies have
B. Travis, M. Schumacher
semanticscholar   +1 more source

Integrated control of bacterial growth and stress response by (p)ppGpp in Escherichia coli: A seesaw fashion

iScience
Summary To thrive in nature, bacteria have to reproduce efficiently under favorable conditions and persist during stress. The global strategy that integrates the growth control and stress response remains to be explored.
Manlu Zhu, Haoyan Mu, Xiongfeng Dai
semanticscholar   +1 more source

Diversity in E. coli (p)ppGpp Levels and Its Consequences

Frontiers in Microbiology, 2020
(p)ppGpp is at the core of global bacterial regulation as it controls growth, the most important aspect of life. It would therefore be expected that at least across a species the intrinsic (basal) levels of (p)ppGpp would be reasonably constant.
Beny Spira, Katia Ospino
doaj   +1 more source

Role of RelA-synthesized (p)ppGpp and ROS-induced mutagenesis in de novo acquisition of antibiotic resistance in E. coli

iScience
Summary The stringent response of bacteria to starvation and stress also fulfills a role in addressing the threat of antibiotics. Within this stringent response, (p)ppGpp, synthesized by RelA or SpoT, functions as a global alarmone.
Wenxi Qi, M. Jonker, Wim de leeuw, S. Brul, B. T. ter Kuile   +4 more
semanticscholar   +1 more source

Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase

, 2006
Brockmann-Gretza O, Kalinowski J. Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase. BMC Genomics.
Brockmann-Gretza Olaf, Kalinowski Jörn, Kalinowski, Jörn, Brockmann-Gretza, Olaf, Olaf Brockmann-Gretza, Jörn Kalinowski   +5 more
core   +1 more source

Acabou o rolê?

Revista Espaço Acadêmico, 2023
Diante das inúmeras consequências impostas pelo contágio da Covid-19 as sociedades precisaram readaptar os vários processos de vivências e experiências cotidianas presentes.
Paulo de Tarso Xavier Sousa Junior, Elaine Ferreira do Nascimento   +1 more
doaj  

Guanosine Tetraphosphate Has a Similar Affinity for Each of Its Two Binding Sites on Escherichia coli RNA Polymerase

Frontiers in Microbiology, 2020
During nutrient deprivation, the bacterial cell undergoes a stress response known as the stringent response. This response is characterized by induction of the nucleotide derivative guanosine tetraphosphate (ppGpp) that dramatically modulates the cell’s ...
Angela R. Myers, Danielle P. Thistle, Wilma Ross, Richard L. Gourse   +3 more
doaj   +1 more source