(p)ppGpp: Magic Modulators of Bacterial Physiology and Metabolism [PDF]
Frontiers in Microbiology, 2020 When bacteria experience growth-limiting environmental conditions, the synthesis of the hyperphosphorylated guanosine derivatives (p)ppGpp is induced by enzymes of the RelA/SpoT homology (RSH)-type protein family. High levels of (p)ppGpp induce a process
Wieland Steinchen +2 more
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Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter. [PDF]
PLoS GeneticsAs rapidly growing bacteria begin to exhaust nutrients, their growth rate slows, ultimately leading to the non-replicative state of quiescence. Adaptation to nutrient limitation requires widespread metabolic remodeling that is in part mediated by the ...
Molly Hydorn +4 more
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Similar and Divergent Roles of Stringent Regulator (p)ppGpp and DksA on Pleiotropic Phenotype of Yersinia enterocolitica [PDF]
Microbiology Spectrum, 2022 Stringent response plays an important role in the response of Enterobacteriaceae pathogens to rapid environmental changes. It has been shown that synergistic and antagonistic actions exist between the signaling molecules (p)ppGpp and DksA in several ...
Can Huang +3 more
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Dynamic Metabolic Response to (p)ppGpp Accumulation in Pseudomonas putida [PDF]
Frontiers in Microbiology, 2022 The stringent response is a ubiquitous bacterial reaction triggered by nutrient deprivation and mediated by the intracellular concentrations of ppGpp and pppGpp.
Philippe Vogeleer, Fabien Létisse
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(p)ppGpp Metabolism and Antimicrobial Resistance in Bacterial Pathogens [PDF]
Frontiers in Microbiology, 2020 Single cell microorganisms including pathogens relentlessly face myriads of physicochemical stresses in their living environment. In order to survive and multiply under such unfavorable conditions, microbes have evolved with complex genetic networks ...
Bhabatosh Das, Rupak K. Bhadra
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(p)ppGpp imposes graded transcriptional changes to impair motility and promote antibiotic tolerance in biofilms [PDF]
npj Biofilms and Microbiomes(p)ppGpp is the master regulator of bacterial stress responses, orchestrating cellular physiology via the stringent response to promote survival and adaptation.
Florian Engelhardt +6 more
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Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp [PDF]
mBioGuanosine penta- and tetraphosphate [(p)ppGpp] and their adenosine analogs [(p)ppApp] are bacterial second messengers known as alarmones. Members of the RelA-SpoT homolog (RSH) family synthesize (p)ppGpp to mediate the stringent response during nutrient ...
Shehryar Ahmad +10 more
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Recent functional insights into the magic role of (p)ppGpp in growth control [PDF]
Computational and Structural Biotechnology Journal, 2023 Rapid growth and survival are two key traits that enable bacterial cells to thrive in their natural habitat. The guanosine tetraphosphate and pentaphosphate [(p)ppGpp], also known as “magic spot”, is a key second messenger inside bacterial cells as well ...
Haoyan Mu +5 more
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Survival of the Fittest: The Relationship of (p)ppGpp With Bacterial Virulence [PDF]
Frontiers in Microbiology, 2020 The signaling nucleotide (p)ppGpp has been the subject of intense research in the past two decades. Initially discovered as the effector molecule of the stringent response, a bacterial stress response that reprograms cell physiology during amino acid ...
Shivani Kundra +2 more
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Functional interplay between (p)ppGpp and RNAP in Acinetobacter baumannii. [PDF]
PLoS PathogensThe (p)ppGpp-dependent stress response is required for pathogenic bacteria to survive both outside and inside the host but the mechanisms behind this survival are mostly unknown. In this study, we characterize the (p)ppGpp metabolism in the opportunistic
Anthony Perrier +2 more
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