Inducible expression of (pp)pGpp synthetases in Staphylococcus aureus is associated with activation of stress response genes [PDF]
PLoS Genetics, 2020 The stringent response is characterized by the synthesis of the messenger molecules pppGpp, ppGpp or pGpp (here collectively designated (pp)pGpp). The phenotypic consequences resulting from (pp)pGpp accumulation vary among species and can be mediated by ...
Andrea Salzer +2 more
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The nucleotide pGpp acts as a third alarmone in Bacillus, with functions distinct from those of (p)ppGpp [PDF]
Nature Communications, 2020 Nucleotides pppGpp and ppGpp regulate bacterial responses to nutritional and other stresses, while the potential roles of the related pGpp are unclear. Here, Yang et al. systematically identify proteins interacting with these nucleotides in Bacillus, and
Jin Yang +2 more
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Direct detection of stringent alarmones (pp)pGpp using malachite green [PDF]
Microbial CellThe alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on developing new drugs
Dominik Rejman +2 more
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Small Alarmone Synthetase SasA Expression Leads to Concomitant Accumulation of pGpp, ppApp, and AppppA in Bacillus subtilis [PDF]
Frontiers in Microbiology, 2020 (p)ppGpp is a highly conserved bacterial alarmone which regulates many aspects of cellular physiology and metabolism. In Gram-positive bacteria such as B.
Danny K Fung +2 more
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Sound the (Smaller) Alarm: The Triphosphate Magic Spot Nucleotide pGpp [PDF]
Infection and Immunity, 2023 It has recently become evident that the bacterial stringent response is regulated by a triphosphate alarmone (pGpp) as well as the canonical tetra- and pentaphosphate alarmones ppGpp and pppGpp [together, (p)ppGpp]. Often dismissed in the past as an artifact or degradation product, pGpp has been confirmed as a deliberate endpoint of multiple synthetic ...
Erin B Purcell
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PgpP is a broadly conserved phosphatase required for phosphatidylglycerol lipid synthesis [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaThe cytoplasmic membrane of bacteria is composed of a phospholipid bilayer made up of a diverse set of lipids. Phosphatidylglycerol (PG) is one of the principal constituents and its production is essential for growth in many bacteria.
Angelika Grundling +2 more
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Stringent Response in Mycobacteria: From Biology to Therapeutic Potential [PDF]
Pathogens, 2021 Mycobacterium tuberculosis is a human pathogen that can thrive inside the host immune cells for several years and cause tuberculosis. This is due to the propensity of M.
Gunjan Arora +2 more
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Molecular Mechanism of Regulation of the Purine Salvage Enzyme XPRT by the Alarmones pppGpp, ppGpp, and pGpp [PDF]
Journal of Molecular Biology, 2020 ABSTRACT The alarmones pppGpp and ppGpp mediate starvation response and maintain purine homeostasis to protect bacterial species. Xanthine phosphoribosyltransferase (XPRT) is a purine salvage enzyme that produces the nucleotide XMP from PRPP and xanthine. Combining structural, biochemical and genetic analyses, we show
Brent W Anderson +2 more
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Functional Characterization of a Small Alarmone Hydrolase in Corynebacterium glutamicum [PDF]
Frontiers in Microbiology, 2018 The (pp)pGpp metabolism is an important component of bacterial physiology as it is involved in various stress responses and mechanisms of cell homeostasis, e.g., the regulation of growth.
Matthias Ruwe +2 more
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Author Correction: The nucleotide pGpp acts as a third alarmone in Bacillus, with functions distinct from those of (p)ppGpp [PDF]
Nature Communications, 2021 Jin Yang +7 more
doaj +4 more sources