The Ps and Qs of alarmone synthesis in Staphylococcus aureus. [PDF]
PLoS ONE, 2019 During the stringent response, bacteria synthesize guanosine-3',5'-bis(diphosphate) (ppGpp) and guanosine-5'-triphosphate 3'-diphosphate (pppGpp), which act as secondary messengers to promote cellular survival and adaptation.
Ning Yang +5 more
doaj +3 more sources
Molecular Mechanism of Regulation of the Purine Salvage Enzyme XPRT by the Alarmones pppGpp, ppGpp, and pGpp [PDF]
Journal of Molecular Biology, 2020 ABSTRACT The alarmones pppGpp and ppGpp mediate starvation response and maintain purine homeostasis to protect bacterial species. Xanthine phosphoribosyltransferase (XPRT) is a purine salvage enzyme that produces the nucleotide XMP from PRPP and xanthine. Combining structural, biochemical and genetic analyses, we show
Kenneth Andrew Satyshur +2 more
exaly +6 more sources
Functional Characterization of a Small Alarmone Hydrolase in Corynebacterium glutamicum [PDF]
Frontiers in Microbiology, 2018 The (pp)pGpp metabolism is an important component of bacterial physiology as it is involved in various stress responses and mechanisms of cell homeostasis, e.g., the regulation of growth.
Marcus Persicke +2 more
exaly +5 more sources
Author Correction: The nucleotide pGpp acts as a third alarmone in Bacillus, with functions distinct from those of (p)ppGpp [PDF]
Nature Communications, 2021 Jin Yang +7 more
doaj +4 more sources
Identification and Functional Characterization of Small Alarmone Synthetases in Corynebacterium glutamicum [PDF]
Frontiers in Microbiology, 2017 The hyperphosphorylated guanosine derivatives ppGpp and pppGpp represent global regulators of the bacterial stress response, as they act as central elements of the stringent response system.
Marcus Persicke +2 more
exaly +4 more sources
Unique Features of Alarmone Metabolism in Clostridioides difficile [PDF]
Journal of Bacteriology, 2022 The “magic spot” alarmones (pp)pGpp, previously implicated in Clostridioides difficile antibiotic survival, are synthesized by the RelA-SpoT homolog (RSH) of C. difficile (RSH(Cd)) and RelQ(Cd).
Erin B Purcell
exaly +4 more sources
Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation [PDF]
mBio, 2022 Small alarmone hydrolases (SAHs) are alarmone metabolizing enzymes found in both metazoans and bacteria. In metazoans, the SAH homolog Mesh1 is reported to function in cofactor metabolism by hydrolyzing NADPH to NADH.
Danny K. Fung +7 more
doaj +2 more sources
Functional Characterization of Small Alarmone Synthetase and Small Alarmone Hydrolase Proteins from Treponema denticola [PDF]
Microbiology Spectrum, 2023 The stringent response enables bacteria to survive nutrient starvation, antibiotic challenge, and other threats to cellular survival. Two alarmone (magic spot) second messengers, guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp ...
Miao Wang +3 more
doaj +2 more sources
The extended (p)ppGpp family: New dimensions in Stress response [PDF]
Current Research in Microbial Sciences, 2021 Second messenger (p)ppGpp mediated stress response plays a crucial role in bacterial persistence and multiple drug resistance. In E. coli, (p)ppGpp binds to RNA polymerase and upregulates the transcription of genes essential for stress response while ...
Kirtimaan Syal +2 more
doaj +2 more sources
Crosstalk between guanosine nucleotides regulates cellular heterogeneity in protein synthesis during nutrient limitation. [PDF]
PLoS Genetics, 2022 Phenotypic heterogeneity of microbial populations can facilitate survival in dynamic environments by generating sub-populations of cells that may have differential fitness in a future environment.
Simon Diez +3 more
doaj +2 more sources