Results 31 to 40 of about 8,365 (192)

(p)ppGpp: Still Magical? [PDF]

Annual Review of Microbiology, 2008
The fundamental details of how nutritional stress leads to elevating (p)ppGpp are questionable. By common usage, the meaning of the stringent response has evolved from the specific response to (p)ppGpp provoked by amino acid starvation to all responses caused by elevating (p)ppGpp by any means.
Potrykus, Katarzyna, Cashel, Michael
openaire   +3 more sources

(p)ppGpp - an important player during heat shock response. [PDF]

Microlife, 2023
AbstractThe alarmones and second messengers (p)ppGpp are important for the cellular response to amino acid starvation. Although the stringent response is present in many bacteria, the targets and functions of (p)ppGpp can differ between species, and our knowledge of (p)ppGpp targets is constantly expanding.
Driller K, Cornejo FA, Turgay K.
europepmc   +4 more sources

Diversity in (p)ppGpp metabolism and effectors [PDF]

Current Opinion in Microbiology, 2015
Bacteria produce guanosine tetraphosphate and pentaphosphate, collectively named (p)ppGpp, in response to a variety of environmental stimuli. These two remarkable molecules regulate many cellular processes, including the central dogma processes and metabolism, to ensure survival and adaptation.
Kuanqing Liu, Alycia N Bittner, Jue D Wang   +2 more
openaire   +2 more sources

Structural Analysis of (p)ppGpp Reveals Its Versatile Binding Pattern for Diverse Types of Target Proteins

Frontiers in Microbiology, 2020
(p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha, Gajraj Singh Kushwaha, Anupam Patra, Neel Sarovar Bhavesh   +3 more
doaj   +1 more source

Regulation of ytfK by cAMP-CRP Contributes to SpoT-Dependent Accumulation of (p)ppGpp in Response to Carbon Starvation YtfK Responds to Glucose Exhaustion

Frontiers in Microbiology, 2021
Guanosine penta- or tetraphosphate (known as (p)ppGpp) serves as second messenger to respond to nutrient downshift and other environmental stresses, a phenomenon called stringent response.
Laura Meyer, Elsa Germain, Etienne Maisonneuve   +2 more
doaj   +1 more source

Small Alarmone Synthetases RelP and RelQ of Staphylococcus aureus Are Involved in Biofilm Formation and Maintenance Under Cell Wall Stress Conditions

Frontiers in Microbiology, 2020
The stringent response is characterized by the synthesis of the alarmone (p)ppGpp. The phenotypic consequences resulting from (p)ppGpp accumulation vary among species, and for several pathogenic bacteria, it has been shown that the activation of the ...
Andrea Salzer, Daniela Keinhörster, Christina Kästle, Benjamin Kästle, Christiane Wolz   +4 more
doaj   +1 more source

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

PLoS Pathogens, 2021
Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p ...
N Y Elizabeth Chau, Shehryar Ahmad, John C Whitney, Brian K Coombes   +3 more
doaj   +1 more source

(p)ppGpp is required for virulence of Shigella flexneri. [PDF]

Infect Immun
ABSTRACT Infection by the enteric pathogen Shigella flexneri requires transit through the gastrointestinal tract and invasion of and replication within the cells of the host colonic epithelium. This process exposes the pathogen to a range of diverse microenvironments.
Kago G, Turnbough CL, Salazar JC, Payne SM.   +3 more
europepmc   +3 more sources

Role of alarmone (p)ppGpp in the regulation of indole formation depending on glucose content in Escherichia coli

Acta Biomedica Scientifica, 2022
Signaling molecules such as indole (product of tryptophan catabolism) and (p)ppGpp (stringent response regulator) are involved in regulation of physiological processes in bacterial cells aimed to adapt to antibiotics and stresses.
N. M. Kashevarova, A. V. Akhova, E. A. Khaova, A. G. Tkachenko   +3 more
doaj   +1 more source

The constancy of global regulation across a species: the concentrations of ppGpp and RpoS are strain-specific in Escherichia coli

BMC Microbiology, 2011
Background Sigma factors and the alarmone ppGpp control the allocation of RNA polymerase to promoters under stressful conditions. Both ppGpp and the sigma factor σS (RpoS) are potentially subject to variability across the species Escherichia coli.
Phan Katherine, Betteridge Thu, Galbiati Heloisa, Ferenci Thomas, Spira Beny   +4 more
doaj   +1 more source