Results 51 to 60 of about 7,467 (157)
Frontiers in Microbiology, 2020 The nucleotide alarmone (p)ppGpp, signaling the stringent response, is known for more than 5 decades. The cellular turnover of the alarmone is regulated by RelA/SpoT homolog (RSH) superfamily of enzymes.
Sushma Krishnan, Dipankar Chatterji
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The synthesis and function of the alarmone (p)ppGpp in firmicutes
International Journal of Medical Microbiology, 2010 In most bacteria, nutrient limitations provoke the stringent control by the rapid synthesis of the alarmones pppGpp and ppGpp. The most prominent and highly conserved reaction is the repression of rRNA synthesis. Additionally, (p)ppGpp synthesis is also linked to many other physiological changes involving gene activation/repression but also protein ...
Christiane, Wolz +2 more
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Nutritional Control of Elongation of DNA Replication by (p)ppGpp [PDF]
Cell, 2007 DNA replication is highly regulated in most organisms. Although much research has focused on mechanisms that regulate initiation of replication, mechanisms that regulate elongation of replication are less well understood. We characterized a mechanism that regulates replication elongation in the bacterium Bacillus subtilis.
Wang, Jue D. +2 more
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mBio, 2021 During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in ...
Daniel J. Bennison +5 more
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BMC Microbiology, 2010 Background The global ppGpp-mediated stringent response in pathogenic bacteria plays an important role in the pathogenesis of bacterial infections. In Salmonella enterica serovar Typhimurium (S. Typhimurium), several genes, including virulence genes, are
Kumagai Yoshinori +10 more
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Regulation of (p)ppGpp hydrolysis by a conserved archetypal regulatory domain [PDF]
Nucleic Acids Research, 2018 Sensory and regulatory domains allow bacteria to adequately respond to environmental changes. The regulatory ACT (Aspartokinase, Chorismate mutase and TyrA) domains are mainly found in metabolic-related proteins as well as in long (p)ppGpp synthetase/hydrolase enzymes.
Séverin Ronneau +5 more
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Pathogens, 2020 Brucella abortus is a pathogenic bacterium able to proliferate inside host cells. During the first steps of its trafficking, it is able to block the progression of its cell cycle, remaining at the G1 stage for several hours, before it reaches its ...
Mathilde Van der Henst +2 more
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Elucidating the role of (p)ppGpp in mycobacterial persistence against antibiotics [PDF]
IUBMB Life, 2018 AbstractBacterial persistence, the ability of bacteria to survive high concentrations of antibiotics for extended periods of time, is an important contributing factor to therapy failure and development of chronic and recurrent infections. Several recent studies have suggested that this persistence is mediated primarily by (p)ppGpp, through its ...
Ashima Bhaskar +4 more
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BMC Genomics, 2020 Background Pseudomonas syringae is an important plant pathogen, which could adapt many different environmental conditions. Under the nutrient-limited and other stress conditions, P.
Jun Liu +6 more
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The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism [PDF]
Microbiology, 1998 To investigate the metabolism of (p)ppGpp in amino-acid-producing coryneform bacteria, a PCR-based strategy using degenerate consensus oligonucleotides was applied to isolate the rel gene of Corynebacterium glutamicum ATCC 13032. The gene consists of 2283 nucleotides and encodes a protein of 760 amino acids with a molecular mass of 84.4 kDa.
Wehmeier, L +7 more
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