Results 61 to 70 of about 8,365 (192)

(p)ppGpp and Its Role in Bacterial Persistence: New Challenges

Antimicrobial Agents and Chemotherapy, 2020
Antibiotic failure not only is due to the development of resistance by pathogens but can also often be explained by persistence and tolerance. Persistence and tolerance can be included in the “persistent phenotype,” with high relevance for clinics. Two of the most important molecular mechanisms involved in tolerance and persistence are toxin-antitoxin (
Pacios, Olga, Blasco, Lucía, Bleriot, Inés, Fernández-García, Laura, Ambroa, Antón, López-Díaz, María, Bou, Germán, Cantón, Rafael, García-Contreras, Rodolfo, Wood, Thomas K., Tomás, María   +10 more
openaire   +4 more sources

Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8. [PDF]

PLoS ONE, 2015
Actinobacillus pleuropneumoniae is a Gram-negative bacterium and the cause of porcine pleuropneumonia. When the bacterium encounters nutritional starvation, the relA-dependent (p)ppGpp-mediated stringent response is activated.
Gang Li, Fang Xie, Yanhe Zhang, Janine T Bossé, Paul R Langford, Chunlai Wang   +5 more
doaj   +1 more source

Elucidating the role of (p)ppGpp in mycobacterial persistence against antibiotics [PDF]

IUBMB Life, 2018
AbstractBacterial persistence, the ability of bacteria to survive high concentrations of antibiotics for extended periods of time, is an important contributing factor to therapy failure and development of chronic and recurrent infections. Several recent studies have suggested that this persistence is mediated primarily by (p)ppGpp, through its ...
Ashima Bhaskar, Cyntia De Piano, Ekaterina Gelman, John D. McKinney, Neeraj Dhar   +4 more
openaire   +3 more sources

The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism [PDF]

Microbiology, 1998
To investigate the metabolism of (p)ppGpp in amino-acid-producing coryneform bacteria, a PCR-based strategy using degenerate consensus oligonucleotides was applied to isolate the rel gene of Corynebacterium glutamicum ATCC 13032. The gene consists of 2283 nucleotides and encodes a protein of 760 amino acids with a molecular mass of 84.4 kDa.
Wehmeier, L, Schafer, A, Burkovski, A, Kramer, R, Mechold, U, Malke, H, Pühler, Alfred, Kalinowski, Jörn   +7 more
openaire   +2 more sources

(p)ppGpp mediated transcriptional changes during heat stress.

, 2020
(A/B) Global differences in gene expression in wild type versus (p)ppGpp° strains at 37 °C or 48 °C, respectively. Bar tracks indicate the distribution of genes in the respective functional groups.
Volkhard Kaever (152216), Gert Bange (811040), Aaron M. Nuss (8582376), Petra Sudzinová (8582385), Libor Krásný (840910), Daniel N. Wilson (59713), Ingo Hantke (8582379), Heinrich Schäfer (8582373), Bertrand Beckert (7941551), Michael Beckstette (683885), Kürşad Turgay (8582388), Kristina Driller (8582382), Petra Dersch (183557), Christian K. Frese (1517512), Wieland Steinchen (5492543)   +14 more
core   +1 more source

Twenty‐Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology

Yeast, EarlyView.
ABSTRACT All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free‐living microbes directly exposed to a changing environment.
Audrey P. Gasch
wiley   +1 more source

Global Regulation by (p)ppGpp and CodY inStreptococcus mutans [PDF]

Journal of Bacteriology, 2008
ABSTRACTThe RelA, RelP, and RelQ enzymes are responsible for the production of the alarmone (p)ppGpp inStreptococcus mutans. A strain lacking all three synthetases (ΔrelAPQ) does not grow in minimal medium lacking the branched-chain amino acids (BCAA) leucine or valine but grows well if isoleucine is also omitted.
José A, Lemos, Marcelle M, Nascimento, Vanessa K, Lin, Jacqueline, Abranches, Robert A, Burne   +4 more
openaire   +2 more sources

Comparative transcriptomic analysis of global gene expression mediated by (p) ppGpp reveals common regulatory networks in Pseudomonas syringae

BMC Genomics, 2020
Background Pseudomonas syringae is an important plant pathogen, which could adapt many different environmental conditions. Under the nutrient-limited and other stress conditions, P.
Jun Liu, Menghao Yu, Tiyakhon Chatnaparat, Jae Hoon Lee, Yanli Tian, Baishi Hu, Youfu Zhao   +6 more
doaj   +1 more source

A Single‐Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli

Molecular Microbiology, EarlyView.
A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo, Qi Zou, Jilong Qin, Makrina Totsika, Yaoqin Hong, John E. Cronan   +5 more
wiley   +1 more source

Expression of a small (p)ppGpp synthetase, YwaC, in the (p)ppGpp⁰ mutant of Bacillus subtilis triggers YvyD‐dependent dimerization of ribosome [PDF]

MicrobiologyOpen, 2012
AbstractTo elucidate the biological functions of small (p)ppGpp synthetases YjbM and YwaC of Bacillus subtilis, we constructed RIK1059 and RIK1066 strains carrying isopropyl‐β‐D‐thiogalactopyranoside (IPTG) inducible yjbM and ywaC genes, respectively, in the ΔrelA ΔyjbM ΔywaC triple mutant background.
Tagami, Kazumi, Nanamiya, Hideaki, Kazo, Yuka, Maehashi, Marie, Suzuki, Shota, Namba, Eri, Hoshiya, Masahiro, Hanai, Ryo, Tozawa, Yuzuru, Morimoto, Takuya, Ogasawara, Naotake, Kageyama, Yasushi, Ara, Katsutoshi, Ozaki, Katsuya, Yoshida, Masaki, Kuroiwa, Haruko, Kuroiwa, Tsuneyoshi, Ohashi, Yoshiaki, Kawamura, Fujio   +18 more
openaire   +2 more sources