Results 61 to 70 of about 7,467 (157)

Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8. [PDF]

PLoS ONE, 2015
Actinobacillus pleuropneumoniae is a Gram-negative bacterium and the cause of porcine pleuropneumonia. When the bacterium encounters nutritional starvation, the relA-dependent (p)ppGpp-mediated stringent response is activated.
Gang Li, Fang Xie, Yanhe Zhang, Janine T Bossé, Paul R Langford, Chunlai Wang   +5 more
doaj   +1 more source

The Microbiome as a Mirror: Distinguishing Healthy Individuals From Chronic Constipated Patients and Identifying Those With Hidden Psychiatric Burden

Microbiota Medicine Research, EarlyView.
Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi, Ting Yu, Weichen Liu, Ya Jiang, Die Chen, Li Gao, Hui Li, Yurong Tang   +7 more
wiley   +1 more source

Global Regulation by (p)ppGpp and CodY inStreptococcus mutans [PDF]

Journal of Bacteriology, 2008
ABSTRACTThe RelA, RelP, and RelQ enzymes are responsible for the production of the alarmone (p)ppGpp inStreptococcus mutans. A strain lacking all three synthetases (ΔrelAPQ) does not grow in minimal medium lacking the branched-chain amino acids (BCAA) leucine or valine but grows well if isoleucine is also omitted.
José A, Lemos, Marcelle M, Nascimento, Vanessa K, Lin, Jacqueline, Abranches, Robert A, Burne   +4 more
openaire   +2 more sources

Expression of a small (p)ppGpp synthetase, YwaC, in the (p)ppGpp⁰ mutant of Bacillus subtilis triggers YvyD‐dependent dimerization of ribosome [PDF]

MicrobiologyOpen, 2012
AbstractTo elucidate the biological functions of small (p)ppGpp synthetases YjbM and YwaC of Bacillus subtilis, we constructed RIK1059 and RIK1066 strains carrying isopropyl‐β‐D‐thiogalactopyranoside (IPTG) inducible yjbM and ywaC genes, respectively, in the ΔrelA ΔyjbM ΔywaC triple mutant background.
Tagami, Kazumi, Nanamiya, Hideaki, Kazo, Yuka, Maehashi, Marie, Suzuki, Shota, Namba, Eri, Hoshiya, Masahiro, Hanai, Ryo, Tozawa, Yuzuru, Morimoto, Takuya, Ogasawara, Naotake, Kageyama, Yasushi, Ara, Katsutoshi, Ozaki, Katsuya, Yoshida, Masaki, Kuroiwa, Haruko, Kuroiwa, Tsuneyoshi, Ohashi, Yoshiaki, Kawamura, Fujio   +18 more
openaire   +2 more sources

Structural basis for (p)ppGpp-mediated inhibition of the GTPase RbgA [PDF]

Journal of Biological Chemistry, 2018
Efficient adaptation to environmental changes is pivotal for all bacterial cells. Almost all bacterial species depend on the conserved stringent response system to prompt timely transcriptional and metabolic responses according to stress conditions and nutrient depletion.
Patrick, Pausch, Wieland, Steinchen, Maximiliane, Wieland, Thomas, Klaus, Sven-Andreas, Freibert, Florian, Altegoer, Daniel N, Wilson, Gert, Bange   +7 more
openaire   +2 more sources

Direct binding targets of the stringent response alarmone (p)ppGpp [PDF]

Molecular Microbiology, 2012
SummaryThe Escherichia coli stringent response, mediated by the alarmone ppGpp, is responsible for the reorganization of cellular transcription upon nutritional starvation and other stresses. These transcriptional changes occur mainly as a result of the direct effects of ppGpp and its partner transcription factor DksA on RNA polymerase.
Usheer, Kanjee, Koji, Ogata, Walid A, Houry   +2 more
openaire   +2 more sources

Calcium-activated (p)ppGpp Synthetase in Chloroplasts of Land Plants [PDF]

Journal of Biological Chemistry, 2007
The genetic system of chloroplasts, including the machinery for transcription, translation, and DNA replication, exhibits substantial similarity to that of eubacteria. Chloroplasts are also thought to possess a system for generating guanosine 5'-triphosphate ((p)ppGpp), which triggers the stringent response in eubacteria, with genes encoding ...
Tozawa, Y., Nozawa, A., Kanno, T., Narisawa, T., Masuda, S., Kasai, K., Nanamiya, H.   +6 more
openaire   +2 more sources

Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments

Water and Environment Journal, Volume 40, Issue 2, Page 183-202, May 2026.
Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze, Musa Marimani, Katlego Mamabolo, Mrudula Patel   +3 more
wiley   +1 more source

Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption

mSphere, 2020
Bacteria grow in constantly changing environments that can suddenly become completely depleted of essential nutrients. The stringent response, a rewiring of the cellular metabolism mediated by the alarmone (p)ppGpp, plays a crucial role in adjusting ...
Clément Patacq, Nicolas Chaudet, Fabien Létisse   +2 more
doaj   +1 more source

Kontrollierter Transport und lichtinduzierte Freisetzung von Magic Spot Nukleotiden in Escherichia coli

Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.
We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp, Patrick Moser, Anselm Schwoerbel, Xinwei Liu, Johannes Freitag, Pinku Sarmah, Isabel Prucker, Robert Zscherp, Xuan Wang, Philipp Klahn, Hans‐Georg Koch, Gert Bange, Henning J. Jessen   +12 more
wiley   +1 more source