Results 81 to 90 of about 8,365 (192)
Controlled Delivery and Light‐Induced Release of Magic Spot Nucleotides in Escherichia coli
Angewandte Chemie International Edition, Volume 65, Issue 15, 6 April 2026.We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp +12 more
wiley +1 more source
Structural basis for (p)ppGpp-mediated inhibition of the GTPase RbgA [PDF]
Journal of Biological Chemistry, 2018 Efficient adaptation to environmental changes is pivotal for all bacterial cells. Almost all bacterial species depend on the conserved stringent response system to prompt timely transcriptional and metabolic responses according to stress conditions and nutrient depletion.
Patrick, Pausch +7 more
openaire +2 more sources
Selective Fluorescent Chemosensor for the Bacterial Alarmone (p)ppGpp
, 2016 We have developed the first selective fluorescent chemosensor (PyDPA) for (p)ppGpp, a bacterial and plant alarmone. By using pyrene-excimer fluorescence, PyDPA shows very good selectivity for (p)ppGpp from among other nucleotides in water. PyDPA was used
Young-Jae Seok (2457913) +7 more
core +1 more source
HPLC põhine regulaatornukleotiidide (p)ppGpp ja ppApp tasemete analüüs bakterirakus [PDF]
, 2020 Väitekirja elektrooniline versioon ei sisalda publikatsiooneBakteritel on evolutsiooni käigus välja kujunenud arvukalt kohanemismehhanisme, mis aitavad neil ellu jääda ka karmides keskkonnatingimustes.
Alves Oliveira, Sofia Raquel
core
Increased (p)ppGpp levels confer high heat stress resistance.
, 2020 (A-D) Growth of strains with mutations in (p)ppGpp synthetases (relP/Q-: BHS204, relE324V: BHS709; (p)ppGpp°: BHS214) on agar plates at 37 °C, during heat stress (55 °C), oxidative stress (0.1 mM diamide) or salt stress (total concentration of 7% (w/v ...
Volkhard Kaever (152216) +14 more
core +1 more source
Molecular Informatics, Volume 45, Issue 4, April 2026.A DeepQSAR framework integrating a feed‐forward neural network and a recurrent neural network (RNN) was developed to identify antimicrobial peptides with enhanced antibiofilm and antimicrobial activity. The feed‐forward model was trained on in‐house antibiofilm IC50 data to capture quantitative structure–activity relationships, and its learned features
Jiaying You +5 more
wiley +1 more source
Direct binding targets of the stringent response alarmone (p)ppGpp [PDF]
Molecular Microbiology, 2012 SummaryThe Escherichia coli stringent response, mediated by the alarmone ppGpp, is responsible for the reorganization of cellular transcription upon nutritional starvation and other stresses. These transcriptional changes occur mainly as a result of the direct effects of ppGpp and its partner transcription factor DksA on RNA polymerase.
Usheer, Kanjee +2 more
openaire +2 more sources
(p)ppGpp and manganese homeostasis supplementary
, 2019 Supplementary data to "Association of Metal Homeostasis and (p)ppGpp Regulation in the Pathophysiology of Enterococcus faecalis.
José A. Lemos (239435) +2 more
core +1 more source
(p)ppGpp modulates translation during stress response.
, 2020 (A/ B) Relative translation (estimated from puromycin incorporation) of wild type, (p)ppGpp° (BHS214) and Δrel (BHS126) strains during heat stress (A) at 50 °C or (B) at 48 °C or 48/53 °C.
Volkhard Kaever (152216) +14 more
core +1 more source
mLife, Volume 5, Issue 2, Page 217-228, April 2026.Abstract Central carbon metabolism is thought to link reactive oxygen species (ROS) with antibiotic‐mediated bacterial death. During enrichment screening of Escherichia coli with the first‐generation quinolone oxolinic acid, unstable antibiotic‐tolerant mutants containing deficiencies in purB were obtained.
Weiwei Zhu +9 more
wiley +1 more source