Results 81 to 90 of about 7,467 (157)

Ribosome State Distributions Define Escherichia coli Persister Physiology: Links to Formation, Stress Responses, and Resuscitation Dynamics

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The AUCS70/AUCS100 ratio, derived from ribosome sedimentation profiling, quantitatively distinguishes Escherichia coli persisters from growing cells across multiple stress conditions and identifies RMF as the primary target for anti‐persistence strategies. ABSTRACT Persister cells survive antibiotic exposure and contribute to infection relapse, yet the
Hyein Kim, Sooyeon Song
wiley   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Exploring Multifunctional Microbial Genes From the Rhizosphere of Allium ampeloprasum Under Different Fertilization Systems

Environmental DNA, Volume 8, Issue 2, March/April 2026.
This study uncovers key multifunctional genes in the rhizosphere of Allium ampeloprasum under varying fertilization systems. This highlights their roles in nutrient cycling, plant growth promotion, and soil health, thereby offering insight for sustainable agricultural sustainability.
Oluwaseun Emmanuel Shittu, Ben Jesuorsemwen Enagbonma, Olubukola Oluranti Babalola   +2 more
wiley   +1 more source

Oxidative Treatment for Reducing Persistent Populations of Escherichia coli Under Amoxicillin and Gentamicin Pressure

Journal of Biophotonics, Volume 19, Issue 3, March 2026.
Photodynamic inactivation (PDI) with methylene blue and 660 nm LED enhances antibiotic killing of bacteria, accelerating time‐kill kinetics and reducing the MDK99 compared to antibiotics alone. SEM confirms effective cellular damage, demonstrating that PDI potentiates amoxicillin and gentamicin against tolerant bacterial populations. ABSTRACT Bacterial
Bruna C. Correa, Maria Vitória S. Pereira, Vanderlei S. Bagnato, Kate C. Blanco   +3 more
wiley   +1 more source

Cell cycle control and environmental response by second messengers in Caulobacter crescentus

BMC Bioinformatics, 2020
Background Second messengers, c-di-GMP and (p)ppGpp, are vital regulatory molecules in bacteria, influencing cellular processes such as biofilm formation, transcription, virulence, quorum sensing, and proliferation.
Chunrui Xu, Bronson R. Weston, John J. Tyson, Yang Cao   +3 more
doaj   +1 more source

Direct detection of stringent alarmones (pp)pGpp using malachite green

Microbial Cell
The alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on developing new drugs
Muriel Schicketanz, Magdalena Petrová, Dominik Rejman, Margherita Sosio, Stefano Donadio, Yong Everett Zhang   +5 more
doaj   +1 more source

Stringent Response and AggR-Dependent Virulence Regulation in the Enteroaggregative Escherichia coli Strain 042

Frontiers in Microbiology, 2018
Virulence expression in the enteroaggregative Escherichia coli strain 042 requires the transcriptional activator AggR. We show in this report that, as reported for other virulence factors, the nucleotide second messenger (p)ppGpp is needed for a high ...
Mário Hüttener, Alejandro Prieto, Joan Espelt, Manuel Bernabeu, Antonio Juárez, Antonio Juárez   +5 more
doaj   +1 more source

Contributions of SpoT Hydrolase, SpoT Synthetase, and RelA Synthetase to Carbon Source Diauxic Growth Transitions in Escherichia coli

Frontiers in Microbiology, 2018
During the diauxic shift, Escherichia coli exhausts glucose and adjusts its expression pattern to grow on a secondary carbon source. Transcriptional profiling studies of glucose–lactose diauxic transitions reveal a key role for ppGpp. The amount of ppGpp
Llorenç Fernández-Coll, Michael Cashel
doaj   +1 more source

Structural and Mechanistic Analysis of (p)ppGpp Synthetases

, 2017
Eines der herausragenden Merkmale von Mikroorganismen ist ihre Fähigkeit, unter einer Vielzahl und sich schnell ändernden Umweltbedingungen zu überleben. Diese Eigenschaft erlaubt es ihnen eine Vielzahl von verschiedensten Habitaten unseres Planeten zu besiedeln.
openaire   +2 more sources

Crosstalk between (p)ppGpp and other nucleotide second messengers. [PDF]

Curr Opin Microbiol, 2023
Fung DK, Trinquier AE, Wang JD.
europepmc   +1 more source