Results 41 to 50 of about 7,467 (157)
Novel (p)ppGpp Binding and Metabolizing Proteins of
mBio, 2018 The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics.
Yong Zhang +3 more
doaj +1 more source
Possible Roles for Basal Levels of (p)ppGpp: Growth Efficiency Vs. Surviving Stress
Frontiers in Microbiology, 2020 Two (p)ppGpp nucleotide analogs, sometimes abbreviated simply as ppGpp, are widespread in bacteria and plants. Their name alarmone reflects a view of their function as intracellular hormone-like protective alarms that can increase a 100-fold when sensing
Llorenç Fernández-Coll, Michael Cashel
doaj +1 more source
(p)ppGpp and the bacterial cell cycle
Journal of Biosciences, 2016 Genes of the Rel/Spo homolog (RSH) superfamily synthesize and/or hydrolyse the modified nucleotides pppGpp/ ppGpp (collectively referred to as (p)ppGpp) and are prevalent across diverse bacteria and in plant chloroplasts. Bacteria accumulate (p)ppGpp in response to nutrient deprivation (generically called the stringent response) and elicit appropriate ...
Aanisa, Nazir, Rajendran, Harinarayanan
openaire +2 more sources
Role of (p)ppGpp in Biofilm Formation by Enterococcus faecalis [PDF]
Applied and Environmental Microbiology, 2012 ABSTRACT Enterococcus faecalis strain OG1RF and its (p)ppGpp-deficient Δ relA , Δ relQ , and Δ relA Δ relQ mutants were grown in biofilms and evaluated for growth profiles, biofilm morphology, cell viability, and ...
Chavez de Paz, Luis E. +3 more
openaire +4 more sources
eLife, 2019 The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its ...
Brent W Anderson +7 more
doaj +1 more source
Microbial Cell, 2023 The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (viru-lence).
Paulina Katarzyna Grucela +4 more
doaj +1 more source
The Alarmone (p)ppGpp Regulates Primer Extension by Bacterial Primase. [PDF]
J Mol Biol, 2021 Primase is an essential component of the DNA replication machinery, responsible for synthesizing RNA primers that initiate leading and lagging strand DNA synthesis. Bacterial primase activity can be regulated by the starvation-inducible nucleotide (p)ppGpp. This regulation contributes to a timely inhibition of DNA replication upon amino acid starvation
Giramma CN, DeFoer MB, Wang JD.
europepmc +3 more sources
Basal Levels of (p)ppGpp in
mBio, 2013 The stringent response (SR), mediated by the alarmone (p)ppGpp, is a conserved bacterial adaptation system controlling broad metabolic alterations necessary for survival under adverse conditions.
Anthony O. Gaca +6 more
doaj +1 more source
mBio, 2020 The initiation of Escherichia coli chromosomal DNA replication starts with the oligomerization of the DnaA protein at repeat sequences within the origin (ori) region. The amount of ori DNA per cell directly correlates with the growth rate.
Llorenç Fernández-Coll +6 more
doaj +1 more source
Broad-spectrum anti-biofilm peptide that targets a cellular stress response. [PDF]
PLoS Pathogens, 2014 Bacteria form multicellular communities known as biofilms that cause two thirds of all infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional antibiotics.
César de la Fuente-Núñez +4 more
doaj +1 more source