The hns Gene of Escherichia coli Is Transcriptionally Down-Regulated by (p)ppGpp [PDF]
Microorganisms, 2020 Second messenger nucleotides, such as guanosine penta- or tetra-phosphate, commonly referred to as (p)ppGpp, are powerful signaling molecules, used by all bacteria to fine-tune cellular metabolism in response to nutrient availability.
Anna Brandi +3 more
doaj +2 more sources
Structural and Mechanistic Analysis of (p)ppGpp Synthetases
, 2017 Eines der herausragenden Merkmale von Mikroorganismen ist ihre Fähigkeit, unter einer Vielzahl und sich schnell ändernden Umweltbedingungen zu überleben. Diese Eigenschaft erlaubt es ihnen eine Vielzahl von verschiedensten Habitaten unseres Planeten zu besiedeln.
Steinchen, Wieland +1 more
openaire +3 more sources
Intracellular Growth and Cell Cycle Progression are Dependent on (p)ppGpp Synthetase/Hydrolase in Brucella abortus [PDF]
Pathogens, 2020 Brucella abortus is a pathogenic bacterium able to proliferate inside host cells. During the first steps of its trafficking, it is able to block the progression of its cell cycle, remaining at the G1 stage for several hours, before it reaches its ...
Mathilde Van der Henst +2 more
doaj +2 more sources
Role of RelA-synthesized (p)ppGpp and ROS-induced mutagenesis in de novo acquisition of antibiotic resistance in E. coli [PDF]
iScienceSummary: The stringent response of bacteria to starvation and stress also fulfills a role in addressing the threat of antibiotics. Within this stringent response, (p)ppGpp, synthesized by RelA or SpoT, functions as a global alarmone.
Wenxi Qi +4 more
doaj +2 more sources
Effects of (p)ppGpp on the Progression of the Cell Cycle of Caulobacter crescentus [PDF]
Journal of Bacteriology, 2014 ABSTRACT Bacteria must control the progression of their cell cycle in response to nutrient availability. This regulation can be mediated by guanosine tetra- or pentaphosphate [(p)ppGpp], which are synthesized by enzymes of the RelA/SpoT homologue (Rsh) family, particularly under starvation conditions.
Gonzalez Diego, Collier Justine
openaire +6 more sources
A comprehensive analysis of (p)ppGpp signaling in bacteria
(p)ppGpp is a signaling molecule produced by bacteria in response to stresses, particularly amino acid starvation. RelA/SpoT homolog (RSH) enzymes synthesize (p)ppGpp when an uncharged tRNA enters an actively translating ribosome, stalling protein ...
Hydorn, Molly Anne
openaire +2 more sources
Role of (p)ppGpp in antibiotic resistance, tolerance, persistence and survival in Firmicutes [PDF]
MicroLife, 2023 Andrea Salzer, Christiane Wolz
exaly +2 more sources
Live‐Cell Imaging of Guanosine Tetra‐ and Pentaphosphate (p)ppGpp with RNA‐based Fluorescent Sensors** [PDF]
Angewandte Chemie - International Edition, 2021 Zhining Sun, Rigumula Wu, Bin Zhao
exaly +2 more sources
Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp. [PDF]
Nat Commun, 2022 The stringent response enables bacteria to respond to nutrient limitation and other stress conditions through production of the nucleotide-based second messengers ppGpp and pppGpp, collectively known as (p)ppGpp.
Czech L +12 more
europepmc +3 more sources
NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
eLife, 2021 Bacteria regulate their metabolism to adapt and survive adverse conditions, in particular to stressful downshifts in nutrient availability. These shifts trigger the so-called stringent response, coordinated by the signaling molecules guanosine tetra and ...
Loïc Léger +4 more
doaj +1 more source