Functional interplay between (p)ppGpp and RNAP in Acinetobacter baumannii. [PDF]
PLoS PathogensThe (p)ppGpp-dependent stress response is required for pathogenic bacteria to survive both outside and inside the host but the mechanisms behind this survival are mostly unknown. In this study, we characterize the (p)ppGpp metabolism in the opportunistic
Anthony Perrier +2 more
doaj +2 more sources
Bacillus subtilis produces (p)ppGpp in response to the bacteriostatic antibiotic chloramphenicol to prevent its potential bactericidal effect [PDF]
mLife, 2022 Antibiotics combat bacteria through their bacteriostatic (by growth inhibition) or bactericidal (by killing bacteria) action. Mechanistically, it has been proposed that bactericidal antibiotics trigger cellular damage, while bacteriostatic antibiotics ...
Jin Yang +3 more
doaj +2 more sources
Diversity in E. coli (p)ppGpp Levels and Its Consequences [PDF]
Frontiers in Microbiology, 2020 (p)ppGpp is at the core of global bacterial regulation as it controls growth, the most important aspect of life. It would therefore be expected that at least across a species the intrinsic (basal) levels of (p)ppGpp would be reasonably constant.
Beny Spira, Katia Ospino
doaj +3 more sources
How to quantify magic spots - a brief overview of (p)ppGpp detection and quantitation methods [PDF]
Frontiers in Molecular BiosciencesGuanosine tetra- and penta-phosphates, collectively known as (p)ppGpp, are well-known second messengers of cellular stress responses in bacteria and plants.
Filip Gąsior +2 more
doaj +2 more sources
(p)ppGpp and DksA play a crucial role in reducing the efficacy of β-lactam antibiotics by modulating bacterial membrane permeability [PDF]
Microbiology SpectrumThe key signaling molecules in the bacterial stress-sensing pathway, the alarmone (p)ppGpp and the transcription factor DksA, play a crucial role in bacterial survival during nutritional deprivation and exposure to xenobiotics by modulating cellular ...
Meenal Chawla +8 more
doaj +2 more sources
Integrated control of bacterial growth and stress response by (p)ppGpp in Escherichia coli: A seesaw fashion [PDF]
iScienceSummary: To thrive in nature, bacteria have to reproduce efficiently under favorable conditions and persist during stress. The global strategy that integrates the growth control and stress response remains to be explored.
Manlu Zhu, Haoyan Mu, Xiongfeng Dai
doaj +2 more sources
Role of RelA-synthesized (p)ppGpp and ROS-induced mutagenesis in de novo acquisition of antibiotic resistance in E. coli [PDF]
iScienceSummary: The stringent response of bacteria to starvation and stress also fulfills a role in addressing the threat of antibiotics. Within this stringent response, (p)ppGpp, synthesized by RelA or SpoT, functions as a global alarmone.
Wenxi Qi +4 more
doaj +2 more sources
Role of (p)ppGpp in antibiotic resistance, tolerance, persistence and survival in Firmicutes [PDF]
MicroLife, 2023 Andrea Salzer, Christiane Wolz
exaly +2 more sources
NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
eLife, 2021 Bacteria regulate their metabolism to adapt and survive adverse conditions, in particular to stressful downshifts in nutrient availability. These shifts trigger the so-called stringent response, coordinated by the signaling molecules guanosine tetra and ...
Loïc Léger +4 more
doaj +1 more source
(p)ppGpp: Still Magical? [PDF]
Annual Review of Microbiology, 2008 The fundamental details of how nutritional stress leads to elevating (p)ppGpp are questionable. By common usage, the meaning of the stringent response has evolved from the specific response to (p)ppGpp provoked by amino acid starvation to all responses caused by elevating (p)ppGpp by any means.
Potrykus, Katarzyna, Cashel, Michael
openaire +3 more sources