Results 81 to 90 of about 4,765 (208)

Basal level of ppGpp coordinates Escherichia coli cell heterogeneity and ampicillin resistance and persistence

Microbial Cell, 2023
The universal stringent response alarmone ppGpp (guanosine penta and tetra phosphates) plays a crucial role in various aspects of fundamental cell physiology (e.g., cell growth rate, cell size) and thus bacterial tolerance to and survival of external ...
Paulina Katarzyna Grucela, Yong Everett Zhang   +1 more
doaj   +1 more source

The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis

PLoS Genetics, 2020
Bacillus subtilis cells are well suited to study how bacteria sense and adapt to proteotoxic stress such as heat, since temperature fluctuations are a major challenge to soil-dwelling bacteria. Here, we show that the alarmones (p)ppGpp, well known second
Heinrich Schäfer, B. Beckert, C. Frese, Wieland Steinchen, A. Nuss, M. Beckstette, I. Hantke, Kristina Driller, P. Sudzinová, L. Krásný, V. Kaever, P. Dersch, G. Bange, Daniel N. Wilson, Kürşad Turgay   +14 more
semanticscholar   +1 more source

The nucleotide pGpp acts as a third alarmone in Bacillus, with functions distinct from those of (p)ppGpp

Nature Communications, 2020
The alarmone nucleotides guanosine tetraphosphate and pentaphosphate, commonly referred to as (p)ppGpp, regulate bacterial responses to nutritional and other stresses.
Jin Yang, B. Anderson, A. Turdiev, Husan Turdiev, D. Stevenson, D. Amador-Noguez, Vincent T. Lee, Jue D. Wang   +7 more
semanticscholar   +1 more source

Twenty‐Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology

Yeast, EarlyView.
ABSTRACT All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free‐living microbes directly exposed to a changing environment.
Audrey P. Gasch
wiley   +1 more source

A ppGpp-mediated brake on photosynthesis is required for acclimation to nitrogen limitation in Arabidopsis

, 2021
Guanosine pentaphosphate and tetraphosphate (together referred to as ppGpp) are hyperphosphorylated nucleotides found in bacteria and the chloroplasts of plants and algae.
Michel Havaux, Romand, Shanna, Field, Benjamin, Shanna Romand, Citerne, Sylvie, Hatem Fakhfakh, Fakhfakh, Hatem, d'Alessandro, Stefano, Mohamed Belaroussi, Belaroussi, Mohamed, Dussenne, Melanie, Caffarri, Stefano, Cécile Lecampion, Brigitte Ksas, Hela Abdelkefi, Field, Ben, Stefano D'Alessandro, Sylvie Citerne, Havaux, Michel, Caius, José, Ben Field, Stefano Caffarri, Melanie Dussenne, Ksas, Brigitte, Lecampion, Cecile, Jose Caius, Abdelkefi, Hela   +26 more
core   +1 more source

Direct detection of stringent alarmones (pp)pGpp using malachite green

Microbial Cell
The alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on developing new drugs
Muriel Schicketanz, Magdalena Petrová, Dominik Rejman, Margherita Sosio, Stefano Donadio, Yong Everett Zhang   +5 more
doaj   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Relative intracellular ppGpp level of ppGpp biosynthesis gene mutants andcomplementation strains.

, 2019
Relative intracellular ppGpp level of ppGpp biosynthesis gene mutants andcomplementation strains.
Lindsay R. Triplett (3156762), Xiaochen Yuan (3569585), Jie Wang (16762), Quan Zeng (228353), Zhouqi Cui (5462006), George W. Sundin (7252556), Ching-Hong Yang (2027971), Roshni R. Kharadi (7134932)   +7 more
core   +1 more source

Action of the bacterial alarmones (p)ppGpp on translational GTPases

, 2022
Ribosomes are intricate and highly complex macromolecular structures. Their maturation into fully functional entities is aided by a vast number of accessory proteins, many of which belong to the class of GTPases. GTPases do furthermore play pivotal roles
Majkini, Mohamad
core   +1 more source

The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC

mBio, 2019
The stringent response enables bacteria to respond to a variety of environmental stresses, especially various forms of nutrient limitation. During the stringent response, the cell produces large quantities of the nucleotide alarmone ppGpp, which ...
James A. Kraemer, Allen G. Sanderlin, Michael T. Laub   +2 more
doaj   +1 more source