Results 61 to 70 of about 4,765 (208)
(p)ppGpp and Its Role in Bacterial Persistence: New Challenges
Antimicrobial Agents and Chemotherapy, 2020 Antibiotic failure not only is due to the development of resistance by pathogens but can also often be explained by persistence and tolerance. Persistence and tolerance can be included in the “persistent phenotype,” with high relevance for clinics.
O. Pacios +10 more
semanticscholar +1 more source
The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
Communications Biology, 2021 Bacteria synthesize guanosine tetra- and penta phosphate (commonly referred to as (p)ppGpp) in response to environmental stresses. (p)ppGpp reprograms cell physiology and is essential for stress survival, virulence and antibiotic tolerance.
A. Sinha, K. Winther
semanticscholar +1 more source
Frontiers in Microbiology, 2020 The stringent response is characterized by the synthesis of the alarmone (p)ppGpp. The phenotypic consequences resulting from (p)ppGpp accumulation vary among species, and for several pathogenic bacteria, it has been shown that the activation of the ...
Andrea Salzer +4 more
doaj +1 more source
On the Turnover of ppGpp in Escherichia coli
Journal of Biological Chemistry, 1972 Abstract The ribosome inhibitor chloramphenicol brings about a rapid disappearance of ppGpp in both RC+ and RC- cells, suggesting that the antibiotic inhibits the synthesis of ppGpp. The kinetics of ppGpp decay in the presence of chloramphenicol agrees well with the kinetics of ppGpp accumulation, in the antibiotic's absence, both in RC+ cells ...
J, Gallant, G, Margason, B, Finch
openaire +2 more sources
The effect of ppGpp and DksA on NAD+ capped RNA species
, 2023 Bird, Jeremy. G.5´ end ribonucleic acid caps play an important role in both regulation of gene expression and half-life of RNAs. Canonically, eukaryotes utilize the evolutionarily conserved methyl-7-guanosine (m7G) cap for mRNA nuclear export and to ...
George, Raymond Albert, IV
core +1 more source
Recent functional insights into the magic role of (p)ppGpp in growth control
Computational and Structural Biotechnology Journal, 2022 Rapid growth and survival are two key traits that enable bacterial cells to thrive in their natural habitat. The guanosine tetraphosphate and pentaphosphate [(p)ppGpp], also known as “magic spot”, is a key second messenger inside bacterial cells as well ...
Haoyan Mu +5 more
semanticscholar +1 more source
Diversity in (p)ppGpp metabolism and effectors [PDF]
Current Opinion in Microbiology, 2015 Bacteria produce guanosine tetraphosphate and pentaphosphate, collectively named (p)ppGpp, in response to a variety of environmental stimuli. These two remarkable molecules regulate many cellular processes, including the central dogma processes and metabolism, to ensure survival and adaptation.
Kuanqing Liu +2 more
openaire +2 more sources
The alarmones (p)ppGpp directly regulate translation initiation during entry into quiescence
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance All bacteria inevitably encounter conditions that are not conducive to growth and, in response, they can enter into quiescent phenotypes. The nucleotides guanosine tetraphosphate and pentaphosphate ((p)ppGpp) play a key role in this response
Simon Diez +4 more
semanticscholar +1 more source
Cell Chemical Biology, 2021 Bacterial persistence coupled with biofilm formation is directly associated with failure of antibiotic treatment of tuberculosis. We have now identified 4-(4,7-DiMethyl-1,2,3,4-tetrahydroNaphthalene-1-yl)Pentanoic acid (DMNP), a synthetic diterpene ...
A. Tkachenko +9 more
semanticscholar +1 more source
Frontiers in Microbiology, 2021 Guanosine penta- or tetraphosphate (known as (p)ppGpp) serves as second messenger to respond to nutrient downshift and other environmental stresses, a phenomenon called stringent response.
Laura Meyer +2 more
doaj +1 more source