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Microbiology Spectrum, 2023 ppGpp is a ubiquitous small nucleotide messenger that mediates cellular self-protective responses under environmental stress. However, the mechanisms of ppGpp that control transcription and other metabolic processes depend on the species, and ppGpp ...
Yang Song +4 more
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ppGpp functions as an alarmone in metazoa [PDF]
Communications Biology, 2019 Abstract Guanosine 3’,5’-bis(pyrophosphate) (ppGpp) functions as a second messenger in bacteria to adjust their physiology in response to environmental changes. In recent years, the ppGpp-specific hydrolase, metazoan SpoT homolog-1 (Mesh1), was shown to have important roles for growth under nutrient deficiency in
Doshun Ito +9 more
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The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly
Cells, 2019 Many facets of ribosome biogenesis and function, including ribosomal RNA (rRNA) transcription, 70S assembly and protein translation, are negatively impacted upon induction of a nutrient stress-sensing signalling pathway termed the stringent response ...
Daniel J. Bennison +2 more
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Novel (p)ppGpp Binding and Metabolizing Proteins of
mBio, 2018 The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics.
Yong Zhang +3 more
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Frontiers in Microbiology, 2020 The stringent response is characterized by the synthesis of the alarmone (p)ppGpp. The phenotypic consequences resulting from (p)ppGpp accumulation vary among species, and for several pathogenic bacteria, it has been shown that the activation of the ...
Andrea Salzer +4 more
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On the Turnover of ppGpp in Escherichia coli
Journal of Biological Chemistry, 1972 Abstract The ribosome inhibitor chloramphenicol brings about a rapid disappearance of ppGpp in both RC+ and RC- cells, suggesting that the antibiotic inhibits the synthesis of ppGpp. The kinetics of ppGpp decay in the presence of chloramphenicol agrees well with the kinetics of ppGpp accumulation, in the antibiotic's absence, both in RC+ cells ...
J, Gallant, G, Margason, B, Finch
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mBio, 2023 Bacterial cell size is a multifactorial trait that is influenced by variables including nutritional availability and the timing of cell division. Prior work revealed a negative correlation between concentration of the alarmone (p)ppGpp (ppGpp) and cell ...
Sarah E. Anderson +3 more
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Diversity in (p)ppGpp metabolism and effectors [PDF]
Current Opinion in Microbiology, 2015 Bacteria produce guanosine tetraphosphate and pentaphosphate, collectively named (p)ppGpp, in response to a variety of environmental stimuli. These two remarkable molecules regulate many cellular processes, including the central dogma processes and metabolism, to ensure survival and adaptation.
Kuanqing Liu +2 more
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Microbial Cell, 2023 The universal stringent response alarmone ppGpp (guanosine penta and tetra phosphates) plays a crucial role in various aspects of fundamental cell physiology (e.g., cell growth rate, cell size) and thus bacterial tolerance to and survival of external ...
Paulina Katarzyna Grucela +1 more
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Frontiers in Microbiology, 2020 During nutrient deprivation, the bacterial cell undergoes a stress response known as the stringent response. This response is characterized by induction of the nucleotide derivative guanosine tetraphosphate (ppGpp) that dramatically modulates the cell’s ...
Angela R. Myers +3 more
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