Results 31 to 40 of about 4,765 (208)
Novel (p)ppGpp Binding and Metabolizing Proteins of
mBio, 2018 The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics.
Yong Zhang +3 more
doaj +2 more sources
mBio, 2020 The initiation of Escherichia coli chromosomal DNA replication starts with the oligomerization of the DnaA protein at repeat sequences within the origin (ori) region. The amount of ori DNA per cell directly correlates with the growth rate.
Llorenç Fernández-Coll +6 more
doaj +2 more sources
σ54-Promoter Discrimination and Regulation by ppGpp and DksA [PDF]
Journal of Biological Chemistry, 2009 The sigma(54)-factor controls expression of a variety of genes in response to environmental cues. Much previous work has implicated the nucleotide alarmone ppGpp and its co-factor DksA in control of sigma(54)-dependent transcription in the gut commensal Escherichia coli, which has evolved to live under very different environmental conditions than ...
Lisandro M D, Bernardo +3 more
openaire +3 more sources
Regulation of ς factor competition by the alarmone ppGpp [PDF]
Genes & Development, 2002 Many regulons controlled by alternative ς factors, including ς S and ς 32 , are poorly induced in cells lacking the alarmone ppGpp. We show that ppGpp is not absolutely required for the activity of ς S -dependent ...
Miki, Jishage +3 more
openaire +3 more sources
Estudo & Debate, 2023 O objetivo neste artigo é discutir os efeitos da reforma trabalhista (Lei n° 13.467/2017) no sistema de proteção social brasileiro. Metodologicamente, a pesquisa ampara-se na ótica da Economia Social e do Trabalho via diferentes correntes teóricas que ...
Juliano Vargas, William Sousa Vilanova
doaj +1 more source
NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
eLife, 2021 Bacteria regulate their metabolism to adapt and survive adverse conditions, in particular to stressful downshifts in nutrient availability. These shifts trigger the so-called stringent response, coordinated by the signaling molecules guanosine tetra and ...
Loïc Léger +4 more
doaj +1 more source
Control of transcription elongation and DNA repair by alarmone ppGpp
Nature Structural & Molecular Biology, 2023 Second messenger (p)ppGpp (collectively guanosine tetraphosphate and guanosine pentaphosphate) mediates bacterial adaptation to nutritional stress by modulating transcription initiation.
Jacob W. A. Weaver +9 more
semanticscholar +1 more source
ppGpp and RNA-polymerase backtracking guide antibiotic-induced mutable gambler cells.
Molecules and Cells, 2023 Antibiotic resistance is a global health threat and often results from new mutations. Antibiotics can induce mutations via mechanisms activated by stress responses, which both reveal environmental cues of mutagenesis and are weak links in mutagenesis ...
Yin Zhai +6 more
semanticscholar +1 more source
(p)ppGpp – an important player during heat shock response
microLife, 2023 The alarmones and second messengers (p)ppGpp are important for the cellular response to amino acid starvation. Although the stringent response is present in many bacteria, the targets and functions of (p)ppGpp can differ between species, and our ...
Kristina Driller +2 more
semanticscholar +1 more source
Communications Biology, 2023 The cyanobacterium Synechococcus elongatus PCC 7942 accumulates alarmone guanosine tetraphosphate (ppGpp) under stress conditions, such as darkness. A previous study observed that artificial ppGpp accumulation under photosynthetic conditions led to the ...
Ryota Hidese +8 more
doaj +1 more source