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ppGpp is a bacterial cell size regulator [PDF]
Current Biology, 2020 Summary Growth and division are central to cell size. Bacteria achieve size homeostasis by dividing when growth has added a constant size since birth, termed the “adder” principle, by unknown mechanisms [1–4]. Growth is well known to be regulated by ppGpp, which controls anything from ribosome production to metabolic enzyme activity and
Ferhat Büke +4 more
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(p)ppGpp: Magic Modulators of Bacterial Physiology and Metabolism
Frontiers in Microbiology, 2020 When bacteria experience growth-limiting environmental conditions, the synthesis of the hyperphosphorylated guanosine derivatives (p)ppGpp is induced by enzymes of the RelA/SpoT homology (RSH)-type protein family. High levels of (p)ppGpp induce a process
Wieland Steinchen +2 more
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How the initiating ribosome copes with ppGpp to translate mRNAs. [PDF]
PLoS Biology, 2020 During host colonization, bacteria use the alarmones (p)ppGpp to reshape their proteome by acting pleiotropically on DNA, RNA, and protein synthesis. Here, we elucidate how the initiating ribosome senses the cellular pool of guanosine nucleotides and ...
Daria S Vinogradova +7 more
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eLife, 2022 Guanosine pentaphosphate and tetraphosphate (together referred to as ppGpp) are hyperphosphorylated nucleotides found in bacteria and the chloroplasts of plants and algae.
Shanna Romand +12 more
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mBio, 2023 Bacterial cell size is a multifactorial trait that is influenced by variables including nutritional availability and the timing of cell division. Prior work revealed a negative correlation between concentration of the alarmone (p)ppGpp (ppGpp) and cell ...
Sarah E. Anderson +3 more
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Role of (p)ppGpp in antibiotic resistance, tolerance, persistence and survival in Firmicutes
MicroLife, 2023 The stringent response and its signalling nucleotides, pppGpp and ppGpp, have been the subject of intense research since the discovery of (p)ppGpp in 1969.
Andrea Salzer, Christiane Wolz
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ppGpp signaling plays a critical role in virulence of Acinetobacter baumannii
Virulence, 2021 Acinetobacter baumannii, a major nosocomial pathogen, survives in diverse hospital environments, and its multidrug resistance is a major concern. The ppGpp-dependent stringent response mediates the reprogramming of genes with diverse functions in several
Kyeongmin Kim +8 more
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Two P or Not Two P: Understanding Regulation by the Bacterial Second Messengers (p)ppGpp
Annual Review of Microbiology, 2021 Under stressful growth conditions and nutrient starvation, bacteria adapt by synthesizing signaling molecules that profoundly reprogram cellular physiology.
Gert Bange +2 more
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Angewandte Chemie - International Edition, 2021 Guanosine tetra- and pentaphosphate, (p)ppGpp, are important alarmone nucleotides that regulate bacterial survival in stressful environment. A direct detection of (p)ppGpp in living cells is critical for our understanding of the mechanism of bacterial ...
Zhining Sun, Rigumula Wu, Bin Zhao
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Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Cells respond to nutritional challenges by dramatically reprogramming their transcriptomes. In bacteria, transcriptional regulators are often pleiotropic, complicating identification of direct versus indirect effects.
Colin N Dewey +2 more
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