Results 11 to 20 of about 7,972 (181)
Enzymatic activity of PBP1B is required for growth rate-independent ppGpp-mediated resistance to PBP2 inhibitors in E. coli [PDF]
Journal of BacteriologyThe alarmone (p)ppGpp (ppGpp) accumulates in response to starvation and other stress, leading to inhibition of multiple biosynthetic pathways and, at high concentrations, suppression of bacterial growth.
Sarah E. Anderson +2 more
doaj +2 more sources
The ppGpp-HpaR1-gum regulatory pathway modulates exopolysaccharides production in Xanthomonas campestris pv. campestris [PDF]
npj Biofilms and MicrobiomesExopolysaccharides (EPS) are critical components of the biofilm matrix, and ppGpp has been demonstrated to positively influence biofilm formation. Here, we elucidate the underlying mechanism by which ppGpp regulates EPS production by facilitating HpaR1 ...
Kaihong Bai +9 more
doaj +2 more sources
Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter. [PDF]
PLoS GeneticsAs rapidly growing bacteria begin to exhaust nutrients, their growth rate slows, ultimately leading to the non-replicative state of quiescence. Adaptation to nutrient limitation requires widespread metabolic remodeling that is in part mediated by the ...
Molly Hydorn +4 more
doaj +2 more sources
(p)ppGpp: Magic Modulators of Bacterial Physiology and Metabolism
Frontiers in Microbiology, 2020 When bacteria experience growth-limiting environmental conditions, the synthesis of the hyperphosphorylated guanosine derivatives (p)ppGpp is induced by enzymes of the RelA/SpoT homology (RSH)-type protein family. High levels of (p)ppGpp induce a process
VÍCTOR Zegarra +2 more
exaly +3 more sources
(p)ppGpp imposes graded transcriptional changes to impair motility and promote antibiotic tolerance in biofilms [PDF]
npj Biofilms and Microbiomes(p)ppGpp is the master regulator of bacterial stress responses, orchestrating cellular physiology via the stringent response to promote survival and adaptation.
Florian Engelhardt +6 more
doaj +2 more sources
Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli. [PDF]
Angew Chem Int Ed EnglWe synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Popp C +12 more
europepmc +2 more sources
Estudo & Debate, 2023 O objetivo neste artigo é discutir os efeitos da reforma trabalhista (Lei n° 13.467/2017) no sistema de proteção social brasileiro. Metodologicamente, a pesquisa ampara-se na ótica da Economia Social e do Trabalho via diferentes correntes teóricas que ...
Juliano Vargas, William Sousa Vilanova
doaj +1 more source
Communications Biology, 2023 The cyanobacterium Synechococcus elongatus PCC 7942 accumulates alarmone guanosine tetraphosphate (ppGpp) under stress conditions, such as darkness. A previous study observed that artificial ppGpp accumulation under photosynthetic conditions led to the ...
Ryota Hidese +8 more
doaj +1 more source
NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
eLife, 2021 Bacteria regulate their metabolism to adapt and survive adverse conditions, in particular to stressful downshifts in nutrient availability. These shifts trigger the so-called stringent response, coordinated by the signaling molecules guanosine tetra and ...
Loïc Léger +4 more
doaj +1 more source
eLife, 2022 Guanosine pentaphosphate and tetraphosphate (together referred to as ppGpp) are hyperphosphorylated nucleotides found in bacteria and the chloroplasts of plants and algae.
Shanna Romand +12 more
doaj +1 more source