Results 121 to 130 of about 7,467 (157)
The (p)ppGpp synthetase Rsh promotes rifampicin tolerant persister cell formation in Brucella abortus by regulating the type II toxin-antitoxin module mbcTA. [PDF]
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Two P or Not Two P: Understanding Regulation by the Bacterial Second Messengers (p)ppGpp
Annual Review of Microbiology, 2021Under stressful growth conditions and nutrient starvation, bacteria adapt by synthesizing signaling molecules that profoundly reprogram cellular physiology. At the onset of this process, called the stringent response, members of the RelA/SpoT homolog (RSH) protein superfamily are activated by specific stress stimuli to produce several ...
Anastasia Liuzzi +2 more
exaly +4 more sources
(p)ppGpp and Its Role in Bacterial Persistence: New Challenges
Antimicrobial Agents and Chemotherapy, 2020 Antibiotic failure not only is due to the development of resistance by pathogens but can also often be explained by persistence and tolerance. Persistence and tolerance can be included in the “persistent phenotype,” with high relevance for clinics. Two of the most important molecular mechanisms involved in tolerance and persistence are toxin-antitoxin (
Rodolfo García-Contreras +2 more
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(p)ppGpp synthetases are required for the pathogenicity of Salmonella Pullorum in chickens
Microbiological Research, 2021Salmonella Pullorum is a pathogen specific to birds that can cause Pullorum disease in young chickens and lead to considerable economic losses in the poultry industry. During transmission and infection, S. Pullorum will encounter various environmental stresses and host defenses.
Zishu Pan, Guoyuan Wen, Qingping Luo
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Journal of Cellular Physiology, 2010
AbstractIn recent years, emerging and reemerging pathogens resistant to nearly all available antibiotics are on the rise. This limits the availability of effective antibiotics to treat infections, thus it is imperative to develop new drugs. The accumulation of alarmones guanosine tetraphosphate and guanosine pentaphosphate, collectively known as (p ...
Jun, Wu, Quanxin, Long, Jianping, Xie
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AbstractIn recent years, emerging and reemerging pathogens resistant to nearly all available antibiotics are on the rise. This limits the availability of effective antibiotics to treat infections, thus it is imperative to develop new drugs. The accumulation of alarmones guanosine tetraphosphate and guanosine pentaphosphate, collectively known as (p ...
Jun, Wu, Quanxin, Long, Jianping, Xie
openaire +2 more sources
Journal of Cellular Physiology, 2009
AbstractGuanosine 5′‐(tri)diphosphate, 3′‐diphosphate [(p) ppGpp] is a small nucleic acid that helps bacteria survive in limited environments. Gene chip shows that (p) ppGpp is a global transcription‐regulator of genes related to important bacterial metabolic processes.
Jun, Wu, Jianping, Xie
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AbstractGuanosine 5′‐(tri)diphosphate, 3′‐diphosphate [(p) ppGpp] is a small nucleic acid that helps bacteria survive in limited environments. Gene chip shows that (p) ppGpp is a global transcription‐regulator of genes related to important bacterial metabolic processes.
Jun, Wu, Jianping, Xie
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The magic dance of the alarmones (p)ppGpp
Molecular Microbiology, 2016SummaryThe alarmones (p)ppGpp are important second messengers that orchestrate pleiotropic adaptations of bacteria and plant chloroplasts in response to starvation and stress. Here, we review our structural and mechanistic knowledge on (p)ppGpp metabolism including their synthesis, degradation and interconversion by a highly diverse set of enzymes ...
Wieland, Steinchen, Gert, Bange
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Kinetic suppression of translational errors by (p)ppGpp
Molecular and General Genetics MGG, 1982The effect of (p)ppGpp on the accuracy of translation was studied in vitro using a poly(U)-programmed poly(Phe)-synthesizing system operating at incorporation rates and missense error frequencies close to the values obtained in vivo. Simulation of a relaxed phenotype in vitro was accomplished by limitation of the cognate aminoacyl-tRNA synthetase ...
E. Gerhart +3 more
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Translational accuracy enhanced in vitro by (p)ppGpp
Molecular and General Genetics MGG, 1980The effect of (p)ppGpp on the accuracy of translation in vitro was studied with a system that has a missense error frequency similar to that of living bacteria. When poly (U) is translated, limitation of the system in Phe increases the Leu missense error frequency.
E G, Wagner, C G, Kurland
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